Results 91 to 100 of about 44,608 (286)

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Biopiracy versus one-world medicine – from colonial relicts to global collaborative concepts [PDF]

, 2019
Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.Hypothesis: : The One-World ...
Abdelfatah, Sara, Abu-Darwish, Mohammad Sanad, Banerjee, Mita, Bhakta-Guha, Dipita, Bockers, Madeleine, Bolzani, Vanderlan, Daak, Salah, Dawood, Mona, Demirezer, Omur Lutfiye, Efferth, Monika, Efferth, Thomas, El-Seedi, Hesham R., Fischer, Nicolas, Greten, Henry J., Hamdoun, Sami, Hong, Chunlan, Horneber, Markus, Kadioglu, Onat, Khalid, Hassan E., Khalid, Sami A., Kuete, Victor, Mahmoud, Nuha, Marin, José, Mbaveng, Armelle, Midiwo, Jacob, Nakagawa, Hiroshi, Naß, Janine, Ngassapa, Olipa, Ochwang, Dominic, Omosa, Leonida K., Ooko, Edna A., Paramasivan, Poornima, Paul, Norbert W., Rodriguez Romero, Marta, Saeed, Elfatih M., Saeed, Mohamed E.M., Salgueiro, Ligia, Seo, Ean-Jeong, Yan, Ge, Yasin, Zahir, Özenver, Nadire   +40 more
core   +2 more sources

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Herbs with anti-lipid effects and their interactions with statins as a chemical anti- hyperlipidemia group drugs: A systematic review. [PDF]

, 2015
BACKGROUND The present systematic review aimed to express the clinical anti-lipid effects of different types of herbs, as well as described studied interactions between herbal remedies and prescribed drugs for hyperlipidemic patients which were based ...
Heidarian, Esfandiar., Mohammadizadeh, Fereshteh., Rafieian-Kopaei, Mahmoud., Rouhi-Boroujeni, Hamid., Rouhi-Boroujeni, Hojjat.   +4 more
core   +5 more sources

Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [PDF]

, 2014
BACKGROUND: Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration of herbal extracts that modulate
Eun Nam Kim, Hee Eun Kang, Hye Suk Lee, Hyeon-Uk Jeong, Im-Sook Song, Miwon Son, Sang-Zin Choi, Soon-Sang Kwon, Tae Yeon Kong   +8 more
core   +1 more source

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, EarlyView.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines [PDF]

, 2017
published_or_final_versio
Cheung, F, Feng, Y, HONG, M, Huang, J, LI, S, Tan, HY, Wang, N   +6 more
core   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Drinking of Salvia officinalis tea increases CCl4-induced hepatotoxicity in mice [PDF]

, 2007
In a previous study, the drinking of a Salvia officinalis tea (prepared as an infusion) for 14 days improved liver antioxidant status in mice and rats where, among other factors, an enhancement of glutathione-S-transferase (GST) activity was observed ...
Ferreira, Manuel Fernandes, Lima, Cristóvão F., Wilson, Cristina Pereira   +2 more
core   +1 more source

Artificial Intelligence–Driven and Digital Practices for Circular Business and Finance: Insights for Advancing Hubs for Circularity

Business Strategy and the Environment, EarlyView.
ABSTRACT The emerging concept of Hubs for Circularity (H4Cs) presents an opportunity to create collaborative, self‐sustaining regional industrial ecosystems that drive circular economy transitions at scale. However, the operationalisation of H4Cs faces financial, organisational and data‐driven challenges.
Aditya Tripathi, Marcos R. Machado, Laura Spierdijk, Devrim Murat Yazan   +3 more
wiley   +1 more source