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2021
Modern drugs are being more replaced by herbal medicines especially for chronic and severe diseases for their fewer side effects, better patient adherence, cost-effectiveness and vast availability. However, an unexpected herb-drug interaction (HDI) can amplify or block the action of drugs which is a detrimental issue to be considered.
R. Vimalavathini +2 more
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Modern drugs are being more replaced by herbal medicines especially for chronic and severe diseases for their fewer side effects, better patient adherence, cost-effectiveness and vast availability. However, an unexpected herb-drug interaction (HDI) can amplify or block the action of drugs which is a detrimental issue to be considered.
R. Vimalavathini +2 more
openaire +1 more source
Predicting Pharmacokinetic Herb-Drug Interactions
Drug Metabolism and Drug Interactions, 2004In vitro and in vivo studies have indicated that the induction or inhibition of cytochrome P450 (CYP) is one of the major mechanisms for some clinically important pharmacokinetic herb-drug interactions. Thus, an attempt was made to predict pharmacokinetic herb-drug interactions using the pharmacokinetic principles that are used for predicting drug-drug
Zhou, Shufeng +7 more
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Herb–drug pharmacokinetic interactions reviewed
Expert Opinion on Drug Metabolism & Toxicology, 2010the global increase in the popularity of alternative medicines has raised renewed concerns regarding herb-drug interactions. These interactions are especially important for drugs with narrow therapeutic indices and may either be pharmacodynamic or pharmacokinetic in nature.pharmacokinetic interactions which may exist between herbs and drugs, and the ...
Clemence, Tarirai +2 more
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Wiener medizinische Wochenschrift (1946), 2007
Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing ...
Johannes, Freudenstein, Thomas, Nisslein
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Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing ...
Johannes, Freudenstein, Thomas, Nisslein
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An Insight into Herb - Drug Interactions
International Journal of Pharmaceutical Sciences and Nanotechnology, 1970Alternative medicine is becoming popular worldwide and this is clearly evident from the rapidly escalating sales figures. The time tested and clinically proven herbal medicines like St. John’s wort, Ginkgo biloba, Garlic, Ephedra, Echinacea etc., make up most of the world’s market as for as alternative medicine is concerned. In spite of its increasing
Harish Chandra Rodda +4 more
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Herb-Drug Interactions: Focus on Pharmacokinetics
CNS Spectrums, 2001ABSTRACTRecent literature regarding drug-drug, herb-drug, and food-drug interactions must not be ignored; nor can they always be taken at face value. Studies have shown that St. John's wort (SJW)(Hypericum perforatum) can reduce plasma levels of indinavir, cyclosporin, digoxin, and possibly other drugs as well.
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Herb–drug interactions: an overview of the clinical evidence
Fundamental & Clinical Pharmacology, 2005AbstractHerbal medicines are mixtures of more than one active ingredient. The multitude of pharmacologically active compounds obviously increases the likelihood of interactions taking place. Hence, the likelihood of herb–drug interactions is theoretically higher than drug–drug interactions, if only because synthetic drugs usually contain single ...
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Herb-Drug Interactions: An Evidence Based Approach
Current Medicinal Chemistry, 2004The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse ...
P D, Coxeter +3 more
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Herb-Drug Interactions and Confounding in Clinical Trials
Journal of Herbal Pharmacotherapy, 2002Herb-drug interactions are being recognized for their potential to reduce the efficacy of, or cause additive side effects with, conventional medications. Herb use, particularly when undisclosed to investigators, may be a potential unforeseen confounding variable in clinical trials.
Stephen C, Piscitelli, Aaron H, Burstein
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In vitro and in vivo assessment of herb drug interactions
Life Sciences, 2006Herbal products contain several chemicals that are metabolized by phase 1 and phase 2 pathways and also serve as substrates for certain transporters. Due to their interaction with these enzymes and transporters there is a potential for alteration in the activity of drug metabolizing enzymes and transporters in presence of herbal components.
Raman, Venkataramanan +2 more
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