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Herb-Drug Interactions and Hepatotoxicity
Current Drug Metabolism, 2019Background:In recent times, herbals or phytomedicines have become very popular due to their global acceptance as a complementary and alternative remedy. While modern drugs are commercially available only after laboratory validations, clinical trials, as well as approval from drug regulatory authorities, majority of the marketed herbal products lack ...
Mohammad K, Parvez, Vikas, Rishi
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Evaluation of metabolism-mediated herb-drug interactions
Archives of Pharmacal Research, 2011As the use of herbal medicines increases, the public health consequences of drug-herb interactions are becoming more significant. Herbal medicines share the same drug metabolizing enzymes and drug transporters, including cytochrome P450 enzymes (CYPs), glucuronosyltransferases (UGTs), and P-glycoprotein, with several clinically important drugs ...
Dong Hee, Na +5 more
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2021
Modern drugs are being more replaced by herbal medicines especially for chronic and severe diseases for their fewer side effects, better patient adherence, cost-effectiveness and vast availability. However, an unexpected herb-drug interaction (HDI) can amplify or block the action of drugs which is a detrimental issue to be considered.
R. Vimalavathini +2 more
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Modern drugs are being more replaced by herbal medicines especially for chronic and severe diseases for their fewer side effects, better patient adherence, cost-effectiveness and vast availability. However, an unexpected herb-drug interaction (HDI) can amplify or block the action of drugs which is a detrimental issue to be considered.
R. Vimalavathini +2 more
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Drugs, 2005
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations.
Zeping, Hu +8 more
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Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations.
Zeping, Hu +8 more
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Predicting Pharmacokinetic Herb-Drug Interactions
Drug Metabolism and Drug Interactions, 2004In vitro and in vivo studies have indicated that the induction or inhibition of cytochrome P450 (CYP) is one of the major mechanisms for some clinically important pharmacokinetic herb-drug interactions. Thus, an attempt was made to predict pharmacokinetic herb-drug interactions using the pharmacokinetic principles that are used for predicting drug-drug
Zhou, Shufeng +7 more
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Herb–drug pharmacokinetic interactions reviewed
Expert Opinion on Drug Metabolism & Toxicology, 2010the global increase in the popularity of alternative medicines has raised renewed concerns regarding herb-drug interactions. These interactions are especially important for drugs with narrow therapeutic indices and may either be pharmacodynamic or pharmacokinetic in nature.pharmacokinetic interactions which may exist between herbs and drugs, and the ...
Clemence, Tarirai +2 more
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Nuclear receptors in herb–drug interactions
Drug Metabolism Reviews, 2013Widespread usage of herbs as supplements or medicines raises the potential of herb-drug interactions (HDIs). Basically, HDIs occur by pharmacokinetic and/or pharmacodynamic pathways. Nuclear receptors (NRs) are a class of transcription factors whose role in drug interactions has been defined. A large number of herbs activate NRs, resulting in HDIs.
Madhav, Sachar, Xiaochao, Ma
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Wiener medizinische Wochenschrift (1946), 2007
Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing ...
Johannes, Freudenstein, Thomas, Nisslein
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Herbal therapeutics are increasingly associated with herb drug interactions. The vast majority of the purported cases is unsubstantiated and misinterpreted. Pharmacological and clinical studies should only be demanded in cases of reliable evidence. First steps to be taken by manufacturers of herbal drugs should be in vitro studies with metabolizing ...
Johannes, Freudenstein, Thomas, Nisslein
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Herb-Drug Interactions: An Evidence Based Approach
Current Medicinal Chemistry, 2004The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse ...
P D, Coxeter +3 more
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Herb-Drug Interactions: Focus on Pharmacokinetics
CNS Spectrums, 2001ABSTRACTRecent literature regarding drug-drug, herb-drug, and food-drug interactions must not be ignored; nor can they always be taken at face value. Studies have shown that St. John's wort (SJW)(Hypericum perforatum) can reduce plasma levels of indinavir, cyclosporin, digoxin, and possibly other drugs as well.
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