Results 181 to 190 of about 3,222,626 (259)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cascade Chatbot: A Scalable Approach to Family-Based Genetic Testing for Hereditary Cancer Syndromes. [PDF]

JCO Clin Cancer Inform
Davis Rivera LB, Mitchell L, Ahsan MD, Chandler I, Epstein ES, Borsato EP, Allen C, Kaphingst KA, Bradshaw RL, Del Fiol G, Kawamoto K, Madeo AC, Sharaf RN, Frey MK.   +13 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

VAF-tumor content graph: a simple visual framework for interpreting hereditary cancer variants and supporting genetic counseling in tumor-only sequencing. [PDF]

J Hum Genet
Kashima M, Tsubamoto H, Ueda T, Kinjo C, Okada C, Muroi Y, Ueda M, Otsuki T, Kataoka K, Nagahashi M, Matsuda I, Sawai H, Kijima T, Miyazaki A.   +13 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Integrating germline and tumor sequencing to improve hereditary cancer diagnosis and care. [PDF]

Eur J Hum Genet
de Voer RM, Valle L.
europepmc   +1 more source

Hereditary and familial breast and ovarian cancer: spectrum of related tumors [PDF]

, 2008
Pensabene, Matilde
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Differences in Cascade Genetic Testing Among Families With Hereditary Cancer Risk.

JAMA Netw Open
Namey E, Horton C, Dudley B, Carraway C, Komala T, Milliard C, Namey T, Karloski E, Brand R.   +8 more
europepmc   +1 more source

Impact of Hereditary Cancer Susceptibility in Solid-Organ Transplant Recipients. [PDF]

JCO Precis Oncol
Khuu N, Jeanjean M, Donenberg T, Silva Smith R, Sussman D, Vianna R, Ciancio G, Guo Y, Tekin M, Borja NA.   +9 more
europepmc   +1 more source