Results 191 to 200 of about 3,222,626 (259)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Blueprint for building a patient-centered hereditary cancer program based on stakeholder perspectives. [PDF]

Gynecol Oncol Rep
Soussana TN, Primiano M, Ahsan MD, Baron C, Mitchell L, Sharaf RN, Frey MK.   +6 more
europepmc   +1 more source

Meeting abstracts from the Annual Conference on Hereditary Cancers 2015

Hereditary Cancer in Clinical Practice, 2017
Ella R. Thompson, Michelle Wong-Brown, Simone M. Rowley, Susan Dooley, Na Lil, Michael Hipwell, Simone McInerny, Cliff Meldrum, Lisa Devereux, David Mossman, Alison H. Trainer, Briar-Rose Millar, Gillian Mitchell, Cate Smith, Paul A. James, Ian G. Campbell, Rodney J. Scott, Katarzyna Klonowska, Anna Jakubowska, Jelena Maksimenko, Arvids Irmejs, Miki Nakazawa-Miklasevica, Inga Melbarde-Gorkusa, Genadijs Trofimovics, Janis Gardovskis, Edvins Miklasevics, Karolina Tęcza, Jolanta Pamuła-Piłat, Joanna Łanuszewska, Ewa Grzybowska, Edvins Miklasevics, M. Szwiec, J. Tomiczek-Szwiec, M. Gełej, C. Cybulski, T. Huzarski, E. Kilar, Małgorzata Oczko-Wojciechowska, Michał Świerniak, Jolanta Krajewska, Małgorzata Kowalska, Tomasz Tyszkiewicz, Agnieszka Pawlaczek, Michał Jarząb, Monika Kowal, Dagmara Rusinek, Jadwiga Zebracka-Gala, Agnieszka Czarniecka, Barbara Jarzab, Andrzej Plawski, Paweł Borun, Joanna Szczepinska, Monika Siolek, Beata Kozak-Klonowska, Katarzyna Kaczmarek, Magdalena Muszyńska, Wojciech Marciniak, Grzegorz Sukiennicki, Marcin Lener, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Tomasz Gromowski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Oleg Oszurek, Cezary Cybulski, Tadeusz Dębniak, Antoni Morawski, Anna Jakubowska, Jan Lubiński, Grzegorz Sukiennicki, Magdalena Muszyńska, Wojciech Marciniak, Katarzyna Kaczmarek, Marcin Lener, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Tomasz Gromowski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Oleg Oszurek, Cezary Cybulski, Tadeusz Dębniak, Antoni Morawski, Anna Jakubowska, Jan Lubiński, Michał Post   +88 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Primary care stakeholder perspectives on clinical implementation of patient-reported hereditary cancer risk-assessment. [PDF]

BMC Prim Care
Gurram A, Ibidapo T, Bereket S, Gimpel N, Day C, Pirzadeh-Miller S, Makhnoon S.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Redefining holistic care for gynecologic hereditary cancer syndromes through universal social work referrals. [PDF]

Gynecol Oncol Rep
Gaddipati P, Iyer S, Kirby M, Chandler IR, Primiano M, Raghunandan A, Grant B, Karimaghaie T, Sharaf RN, Frey MK, Epstein ES.   +10 more
europepmc   +1 more source