Results 211 to 220 of about 3,222,626 (259)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Molecular profiling unveils genetic complexity and identifies potential new driver mechanisms in head and neck paragangliomas

Genes and Diseases
Sara Mellid, Eduardo Caleiras, Ángel M. Martínez-Montes, Alicia Arenas, Scherezade Jiménez, María Monteagudo, Rocío Letón, Roberta Radu, Ruth Álvarez-Díaz, Ester Arroba, Alberto Diaz-Talavera, Natalia Martínez-Puente, Cristina Álvarez-Escolá, Marta Pineda, Milagros Balbín, Fátima Al-Shahrour, Cristina Rodriguez-Antona, Cristina Montero-Conde, Luis J. Leandro-García, Emiliano Honrado, Miguel Soria-Tristán, Mercedes Robledo, Alberto Cascón   +22 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Germline variant spectrum of hereditary cancer susceptibility genes in a Chinese cohort. [PDF]

Hum Genomics
Xiong C, Wang X, Ji J, Yu T, Zhang Y, Jiang Z, Liu J, Zhang J, Lin Y, Gong B, Zhou Y.   +10 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Implementing genetics clinic for hereditary cancer in resource-constrained settings: a narrative review. [PDF]

J Community Genet
Rungta A, Kapoor A, Redkar G, Kapoor AR, Mishra BK, Gupta A, Sansar B, Kumar A, Chowdhury Z, Patne S, Pradhan S, Sarin R.   +11 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Genomic landscape of hereditary cancer syndromes in the largest cohort in Colombia: a retrospective study. [PDF]

Lancet Reg Health Am
López Rivera JJ, Hernández-Bocanegra N, Aguirre-Guataqui K, Rodríguez Calderón MP, Rios Pinto LC, Cardenas-Prieto R, Piza-Buitrago A, Rueda-Gaitán P, Lamilla J, Isaza-Ruget M.   +9 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

When Covering and Discovering Are at Odds: How the Logic of US Health Insurance Undercuts the Promise and Equity of Precision Medicine for People with Hereditary Cancer Risks. [PDF]

J Health Polit Policy Law
Mrig EH, Schlesinger M, Weiss JM, Pandhi N, Smith KC, Jacobson N, Grob R.   +6 more
europepmc   +1 more source