Results 11 to 20 of about 3,222,626 (259)

Primary and metastatic brain tumours in hereditary cancer syndromes: case reports with and literature review [PDF]

Hereditary Cancer in Clinical Practice
Background Cancer family syndromes can predispose to malignancies of different sites, including brain and spinal tumours. Germline mutations associated with a high risk of cancer can also be found in patients with metastatic tumours of the brain.
Joanna Robaczyńska, Milena Kiljańczyk, Adam Stachowski, Krzysztof Lubiński, Angelos Dodopoulos, Rayane Benali, Adam Kiljańczyk, Rafał Becht, Cezary Cybulski, Jacek Gronwald, Jan Lubiński   +10 more
doaj   +2 more sources

Caracterització i identificació de les formes hereditàries de càncer colorectal [PDF]

, 2008
[cat] El càncer colorectal (CCR) és una de les neoplàsies més prevalents en els països occidentals, i un dels tumors en el que els factors genètics juguen un paper fonamental en el seu desenvolupament.
Balaguer Prunés, Francesc
core   +7 more sources

PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy

Biomolecules, 2022
DNA replication can encounter blocking obstacles, leading to replication stress and genome instability. There are several mechanisms for evading this blockade.
Alberto Díaz-Talavera, Cristina Montero-Conde, Luis Javier Leandro-García, Mercedes Robledo   +3 more
doaj   +1 more source

Genetic testing for hereditary breast cancer in Poland: 1998–2022

Hereditary Cancer in Clinical Practice, 2023
BRCA1 and BRCA2 mutations contribute to both breast cancer and ovarian cancer worldwide. In Poland approximately 4% of patients with breast cancers and 10% of patients with ovarian cancer carry a mutation in BRCA1.
Jacek Gronwald, Cezary Cybulski, Tomasz Huzarski, Anna Jakubowska, Tadeusz Debniak, Marcin Lener, Steven A Narod, Jan Lubinski   +7 more
doaj   +1 more source

SEOM clinical guidelines in hereditary breast and ovarian cancer (2019) [PDF]

, 2020
Mutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian
González-Santiago, S, Llort, G, Aguirre, E, Graña Suárez, Begoña, González-del-Alba, A., González-Santiago, S., Alés-Martínez, J.E., Graña, B., Alés-Martínez, J E, Herrero, A, Llort, G., Ramón y Cajal, T., the, SEOM, Hereditary, Cancer, Working, Group, Ramón Y Cajal, T, Andrés, R, Balmaña, J., Aguirre, E., González-Del-Alba, A, Andrés, R., Balmaña, J, Herrero, A.   +20 more
core   +2 more sources

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Hereditary Cancer in Clinical Practice, 2020
Background Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis.
Katarzyna Białkowska, Wojciech Marciniak, Magdalena Muszyńska, Piotr Baszuk, Satish Gupta, Katarzyna Jaworska-Bieniek, Grzegorz Sukiennicki, Katarzyna Durda, Tomasz Gromowski, Marcin Lener, Karolina Prajzendanc, Alicja Łukomska, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Tadeusz Dębniak, Jan Lubiński, Anna Jakubowska   +17 more
doaj   +1 more source

Correction: Díaz-Talavera et al. PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. Biomolecules 2022, 12, 248

Biomolecules, 2022
To improve the quality of the original article [...]
Alberto Díaz-Talavera, Cristina Montero-Conde, Luis Javier Leandro-García, Mercedes Robledo   +3 more
doaj   +1 more source

Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1

Genome Medicine, 2023
Background Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational spectrum.
Pilar Mur, Julen Viana-Errasti, Sandra García-Mulero, Lorena Magraner-Pardo, Inés G. Muñoz, Tirso Pons, Gabriel Capellá, Marta Pineda, Lidia Feliubadaló, Laura Valle   +9 more
doaj   +1 more source

Current practice of colonoscopy surveillance in patients with lynch syndrome: A multicenter retrospective cohort study in Japan

DEN Open, 2023
Objectives Colonoscopy surveillance reduces the incidence of colorectal cancer through the detection and endoscopic removal of adenomas. Current guidelines recommend that patients with Lynch syndrome should have colonoscopy surveillance every 1–2 years ...
Yasuyuki Miyakura, Akiko Chino, Kohji Tanakaya, Alan Kawarai Lefor, Kiwamu Akagi, Akinari Takao, Masayoshi Yamada, Hideyuki Ishida, Koji Komori, Kazuhito Sasaki, Masashi Miguchi, Keiji Hirata, Tomoya Sudo, Toshiaki Ishikawa, Tatsuro Yamaguchi, Naohiro Tomita, Yoichi Ajioka   +16 more
doaj   +1 more source

SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells

Scientific Reports, 2021
Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs.
Diana Trnski, Maja Sabol, Sanja Tomić, Ivan Štefanac, Milanka Mrčela, Vesna Musani, Nikolina Rinčić, Matea Kurtović, Tina Petrić, Sonja Levanat, Petar Ozretić   +10 more
doaj   +1 more source