Results 91 to 100 of about 15,219 (276)

In-silico Molecular Analysis of Mutated Sequences of HFE1, HFE2, TFR2 and SLC40A1 causing Hemochromatosis Disease [PDF]

International Journal Bioautomation, 2011
Hemochromatosis is a disorder in iron metabolism that is characterized by excess iron absorption. There are two forms of hemochromatosis: primary hemochromatosis is caused by a problem with your genes.
Bilal Hussain, Hassan Tariq, Tayyaba Sultana, Shahid Mahboob, Tariq Niaz   +4 more
doaj  

A Late Presentation of a Fatal Disease: Juvenile Hemochromatosis

Case Reports in Medicine, 2013
Juvenile hemochromatosis is a rare and severe form of hereditary hemochromatosis. We report the case of a 39-year-old female who presented with heart failure and cirrhosis from previously unrecognized juvenile hemochromatosis.
Cynthia Cherfane, Pauline Lee, Leana Guerin, Kyle Brown   +3 more
doaj   +1 more source

Anatomical Structure Segmentation in Liver MRI Images [PDF]

arXiv, 2012
Segmentation of medical images is a challenging task owing to their complexity. A standard segmentation problem within Magnetic Resonance Imaging (MRI) is the task of labeling voxels according to their tissue type. Image segmentation provides volumetric quantification of liver area and thus helps in the diagnosis of disorders, such as Hepatitis ...
arxiv  

Genetic analysis of the correlation between GLP1 action and metabolic liver disease: Insights from Mendelian randomization analysis

Journal of Diabetes Investigation, EarlyView.
Our study provides genetic analysis supporting the beneficial effects of GLP1 action on MASLD. These benefits may be attributed to mechanisms such as lowering blood glucose levels, reducing blood pressure, and improving HDL cholesterol levels. ABSTRACT Purpose Previous studies have shown that glucagon‐like peptide 1 (GLP1) receptor agonists may help ...
Zhiqiang Ma, Binyu Wang, Danpei Li, Xi Chen   +3 more
wiley   +1 more source

Hereditary hemochromatosis in liver transplantation [PDF]

Liver Transplantation and Surgery, 1999
A candidate gene, HFE, was recently described in patients with hereditary hemochromatosis (HH) and found to contain a missense mutation leading to a cysteine to tyrosine substitution (C282Y). A second mutation, H63D, was also found in the gene. This study was undertaken to determine the HFE genotype in liver transplant recipients clinically diagnosed ...
M. Isabel Fiel, Thomas W. King, Charles M. Miller, Swan N. Thung, C. V. R. Rathna Varma, Henry C. Bodenheimer, Thomas D. Schiano, Bruce R. Bacon, Roger K. Wolff, Elizabeth M. Brunt, Cynthia E. Prass, Steven M. Starnes   +11 more
openaire   +3 more sources

Non-piecewise hereditary Nakayama algebras [PDF]

arXiv, 2023
Happel and Seidel gave a classification of piecewise hereditary Nakayama algebras, where the relations are given by some power of the radical. Here we explore what happens for general relations. We develop techniques for showing that a given algebra is not piecewise hereditary, illustrating them on numerous mid-sized examples.
arxiv  

Population screening for hereditary haemochromatosis in Australia: Construction and validation of a state-transition cost-effectiveness model [PDF]

, 2016
INTRODUCTION: HFE-associated haemochromatosis, the most common monogenic disorder amongst populations of northern European ancestry, is characterised by iron overload.
A Asberg, A Asberg, AH Briggs, Australian Government Department of Health, B Gasser, B Graaff de, B Graaff de, BL Hicken, C Morand, CE McLaren, CJ Crooks, D Spiegelhalter, DM Eddy, EP Whitlock, G Gagné, GD McLaren, HA Jackson, Independent Hospital Pricing Authority, Independent Hospital Pricing Authority, J Barton, J Bryant, K Allen, K Thorstensen, KJ Allen, KJ Allen, KJ Allen, LC Gurrin, LM Cullen, M Elmberg, M Stuhrmann, M Worwood, MB Delatycki, MF Drummond, MJ Wood, O Schoffski, P Adams, P Adams, P Adams, P Adams, P Handa, PC Adams, PC Adams, PC Adams, PD Phatak, R Moirand, V Byrnes, WH Rogowski   +46 more
core   +2 more sources

Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer‐related death worldwide. Contemporary advances in systemic and locoregional therapies have led to changes in peer‐reviewed guidelines regarding systemic therapy as well as the possibility of downstaging disease that may enable some patients
Dimitrios Moris, Alessandro Martinino, Sarah Schiltz, Peter J. Allen, Andrew Barbas, Debra Sudan, Lindsay King, Carl Berg, Charles Kim, Mustafa Bashir, Manisha Palta, Michael A. Morse, Michael E. Lidsky   +12 more
wiley   +1 more source

Secondary Erythrocytosis Among Type 2 Diabetes Mellitus Patients With Hypogonadism Using Sodium‐Glucose Cotransporter 2 Inhibitors and Testosterone Replacement Therapy

Endocrinology, Diabetes &Metabolism, Volume 8, Issue 4, July 2025.
Given the frequent association between T2DM and the wide availability and administration of SGLT‐2i as a novel anti‐diabetic class on the one hand and hypogonadism with TRT on the other, concurrent administration may precipitate secondary erythrocytosis.
Maharan Kabha, Hadar Dana, Sameer Kassem, Yoram Dekel, Hilla Cohen, Adnan Zaina   +5 more
wiley   +1 more source

CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients

Haematologica, 2012
Background Most patients with hereditary hemochromatosis in the Caucasian population are homozygous for the p.C282Y mutation in the HFE gene. The penetrance and expression of hereditary hemochromatosis differ largely among cases of homozygous p.C282Y ...
Sara Pelucchi, Raffaella Mariani, Stefano Calza, Anna Ludovica Fracanzani, Giulia Litta Modignani, Francesca Bertola, Fabiana Busti, Paola Trombini, Mirella Fraquelli, Gian Luca Forni, Domenico Girelli, Silvia Fargion, Claudia Specchia, Alberto Piperno   +13 more
doaj   +1 more source