Results 11 to 20 of about 192,458 (292)

Hereditary Hemochromatosis: A Cardiac Perspective. [PDF]

Cureus, 2021
Hereditary hemochromatosis (HH) is a common genetic metabolic disorder characterized by excessive iron absorption and elevated serum iron levels, which accumulate in various organs, such as the heart, pancreas, gonads, and damage these organs.
Joshi PK, Patel SC, Shreya D, Zamora DI, Patel GS, Grossmann I, Rodriguez K, Soni M, Sange I.   +8 more
europepmc   +6 more sources

Overview of Ankle Arthropathy in Hereditary Hemochromatosis. [PDF]

Med Sci (Basel), 2023
Hereditary hemochromatosis (HH) is an autosomal recessive bleeding disorder characterized by tissue overload of iron. Clinical systemic manifestations in HH include liver disease, cardiomyopathy, skin pigmentation, diabetes mellitus, erectile dysfunction,
Calori S, Comisi C, Mascio A, Fulchignoni C, Pataia E, Maccauro G, Greco T, Perisano C.   +7 more
europepmc   +2 more sources

Diagnosis and Management of Hereditary Hemochromatosis. [PDF]

JAMA, 2022
This JAMA Insights Clinical Review discusses the diagnosis and management of hereditary hemochromatosis, including clinical and laboratory characteristics, gene testing and interpretation, and the role of imaging and liver biopsy.
Cabrera E, Crespo G, VanWagner LB.
europepmc   +2 more sources

Twenty-Five Years of Contemplating Genotype-Based Hereditary Hemochromatosis Population Screening. [PDF]

Genes (Basel), 2022
Hereditary hemochromatosis (HH) is a rather frequent, preventable disease because the progressive iron overload affecting many organs can be effectively reduced by phlebotomy. Even before the discovery of the major gene, HFE, in 1996, hemochromatosis was
Schmidtke J.
europepmc   +2 more sources

Quantifying Brain Iron in Hereditary Hemochromatosis Using R2* and Susceptibility Mapping. [PDF]

AJNR Am J Neuroradiol, 2022
BACKGROUND AND PURPOSE: Brain iron dyshomeostasis is increasingly recognized as an important contributor to neurodegeneration. Hereditary hemochromatosis is the most commonly inherited disorder of systemic iron overload.
Sethi SK, Sharma S, Gharabaghi S, Reese D, Chen Y, Adams P, Jog MS, Haacke EM.   +7 more
europepmc   +2 more sources

Hereditary hemochromatosis

Autopsy and Case Reports, 2015
Hereditary hemochromatosis (HH) is the most commonly identified autosomal recessive genetic disorder in the white population, characterized by increased intestinal iron absorption and secondary abnormal accumulation in parenchymal organs, not ...
Stephen A. Geller, Fernando Peixoto Ferraz de Campos   +1 more
doaj   +3 more sources

Hepatocarcinoma with tumor thrombus occupying the right atrium and portal vein in a patient with hereditary hemochromatosis and liver cirrhosis [PDF]

Journal of Mind and Medical Sciences, 2018
We present the case of a 46-year old patient with Child-Pugh class C cirrhosis with MEDL-Score 16, and hepatocellular carcinoma invading the inferior vena cava and the right atrium.
Olga Hilda Orasan, Andreea Maria Stefan, Laura Urian, Anca Mihailov, Ovidiu Fabian, Flaviu Muresan, Iulia Breaban, Sorina Cezara Secara, Simina Tarmure Sarlea, Vasile Negrean, Dorel Sampelean, Angela Cozma   +11 more
doaj   +3 more sources

Case report: A rare case of hereditary hemochromatosis caused by a mutation in the HAMP gene in Fuyang, China [PDF]

Frontiers in Medicine
Hemochromatosis, also known as siderosis, is a disease caused by excessive iron deposition in human organs and tissues, resulting from iron metabolism disorders.
Jinling Wang, Jing Xu, Ning Jiang, Hui Liu, Fengcheng Li, Beibei Wang, Jin Wang, Ziyu Chu, Lin Tan, Shasha Li   +9 more
doaj   +2 more sources

Hereditary hemochromatosis: An opportunity for gene therapy [PDF]

Biological Research, 2006
Levels of body iron should be tightly controlled to prevent the formation of oxygen radicals, lipoperoxidation, genotoxicity, and the production of cytotoxic cytokines, which result in damage to a number of organs.
FERNANDO EZQUER, MARCO T NÚÑEZ, ALEJANDRO ROJAS, JUAN ASENJO, YEDY ISRAEL   +4 more
doaj   +2 more sources

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia

Haematologica, 2019
Genetic iron-overload disorders, mainly hereditary hemochromatosis and untransfused β-thalassemia, affect a large population worldwide. The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading ...
Jing Liu, Wei Liu, Yin Liu, Yang Miao, Yifan Guo, Haoyang Song, Fudi Wang, Hongyu Zhou, Tomas Ganz, Bing Yan, Sijin Liu   +10 more
doaj   +2 more sources