Results 51 to 60 of about 191,909 (291)
Arthritis in hereditary hemochromatosis [PDF]
AbstractSeven pedigrees with 45 members were evaluated for arthropathy associated with hereditary hemochromatosis (HC). Patients with symptomatic extraarticular disease were compared with asymptomatic patients who had evidence of HC on laboratory findings, and with normal subjects.
Mathews Jl, Williams Hj
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Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor [PDF]
Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms. Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate ...
Björkman, Pamela J+3 more
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Hypogonadism in Hereditary Hemochromatosis [PDF]
Abstract Hypogonadism, usually hypogonadotropic in origin, is the most common nondiabetic endocrinopathy in hereditary hemochromatosis (HH). Early studies, usually evaluating small numbers of patients with advanced HH, report prevalence rates of 10–100%. The clinical presentation of HH has changed in recent years as a result of increased
C. H. Walsh, J. H. McDermott
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Analysis of Human Spleen Contamination [PDF]
Besides carbon, oxygen and nitrogen, numerous other elements and their compounds are significant in the body of humans and other animals. Accumulation of some elements and their compounds is recognized by clinical and biochemical evaluation. The physical-
Jan Jakubovsky+2 more
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Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]
The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
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Identification of an iron–hepcidin complex [PDF]
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting with the iron transporter ferroportin,
Alex Drake+30 more
core +2 more sources
Visão atual da hemocromatose hereditária Current approach to hereditary hemochromatosis
A hemocromatose hereditária (HH) está relacionada a diversos distúrbios do metabolismo do ferro que ocasionam sua sobrecarga tecidual. A HH clássica está associada às mutações do gene HFE (homozigose para C282Y ou duplo heterozigose para C282Y/H63D ...
Rodolfo Delfini Cançado+1 more
doaj +1 more source
Polycythemia and Anemia in Hereditary Hemochromatosis [PDF]
Introduction Hereditary hemochromatosis is a syndrome of dysregulated iron homeostasis resulting in the excessive deposition of iron. Hemochromatosis causes pulmonary, pancreatic, and hepatic dysfunction, all of which are risk factors for anemia in the general population. Conversely, iron overload states are thought to predispose to polycythemia.
Adnan Aman Khan+3 more
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Hereditary hemochromatosis associated with autoimmune hemolytic anemia; A case report [PDF]
Hereditary hemochromatosis is a disease associated with highly iron overload. This disease caused by genetic mutations inherited through family. Autoimmune hemolytic anemia is also an important autoimmune disease in which red blood cells (RBC) are ...
Masih Falahatian+2 more
doaj
HFE-Associated Hereditary Haemochromatosis
Hereditary hemochromatosis is a common inherited disorder of the iron metabolism. Screening studies indicate that it has a prevalence of one in 200 to 400, depending on the population studied, and a carrier rate of about one in seven to one in 10.
Emmeke J Eijkelkamp+2 more
doaj +1 more source