Results 61 to 70 of about 9,300 (174)
The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function
Cell Biology International, Volume 50, Issue 10, October 2026.ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit +9 more
wiley +1 more source
Haematologica, 2019 Genetic iron-overload disorders, mainly hereditary hemochromatosis and untransfused β-thalassemia, affect a large population worldwide. The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading ...
Jing Liu +10 more
doaj +1 more source
Journal of Genetic Counseling, Volume 35, Issue 5, October 2026.ABSTRACT The expanding use of whole genome sequencing (WGS) and whole exome sequencing (WES) underscores the need to better understand the psychosocial impact of receiving a broader range of potential results than those generated by other types of genetic testing.
Monica Albu +2 more
wiley +1 more source
CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients
Haematologica, 2012 Background Most patients with hereditary hemochromatosis in the Caucasian population are homozygous for the p.C282Y mutation in the HFE gene. The penetrance and expression of hereditary hemochromatosis differ largely among cases of homozygous p.C282Y ...
Sara Pelucchi +13 more
doaj +1 more source
Hereditary hemochromatosis: An opportunity for gene therapy
Biological Research, 2006 Levels of body iron should be tightly controlled to prevent the formation of oxygen radicals, lipoperoxidation, genotoxicity, and the production of cytotoxic cytokines, which result in damage to a number of organs.
FERNANDO EZQUER +4 more
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Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 2004 The case of a 43-year-old male is presented, with diagnosed diabetes mellitus,heart failure, skin pigmentation, hepatic cirhosis, and hereditary hemochromatosis confirmed by liver biopsy. The objective of this publication is to have hemochromatosis in mind as a differential diagnosis in a middle-aged patient with several pathologies and organs involved.
Lidia, Landa Garrido +4 more
openaire +3 more sources
Should we use proton pump inhibitors as an add-on treatment in hereditary hemochromatosis?
The Turkish Journal of Gastroenterology, 2018 Cite this article as: Kani HT, Gündüz F. Should we use proton pump inhibitors as an add-on treatment in hereditary hemochromatosis? Turk J Gastroenterol 2018; 29: 254-5.
Haluk Tarık Kani, Feyza Gündüz
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Do All Hemochromatosis Patients Have the Same Origin? A Pilot Study of Mitochondrial DNA and Y-DNA
Canadian Journal of Gastroenterology, 2011 BACKGROUND: Mitochondrial DNA (mtDNA) and Y-DNA analysis have been widely used to predict ancestral origin. Genetic anthropologists predict that human civilizations may have originated in central Africa one to two million years previously.
Caitlin J Symonette, Paul C Adams
doaj +1 more source
PLoS ONE, 2019 Hepatic iron overload, a hallmark of hereditary hemochromatosis, triggers progressive liver disease. There is also increasing evidence for a pathogenic role of iron in non-alcoholic fatty liver disease (NAFLD), which may progress to non-alcoholic ...
John Wagner +7 more
doaj +1 more source
Haematologica, 2004 Mutations of the HJV gene, which maps on chromosome 1q21, underlie most cases of juvenile hemochromatosis. We evaluated the frequency of the most common mutation (G320V) of the HJV gene in the Greek population, since 50% of cases of hereditary ...
M Pissia +5 more
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