Results 61 to 70 of about 113,339 (205)

An unusual presentation of seborrheic keratoses in a man with hereditary hemochromatosis [PDF]

, 2017
Hereditary hemochromatosis is an autosomalrecessive disorder that disturbs iron metabolismand results in iron deposition throughout the body.Iron accumulation in various organs may cause awide range of systemic symptoms and cutaneousmanifestations of the
Loh, Tiffany Y, Cohen, Philip R
core   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, Volume 101, Issue 9, Page 2105-2122, September 2026.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

A Successful Living Donor Liver Transplantation Using Hepatic Iron Deposition Graft Suspected by Magnetic Resonance Imaging

Case Reports in Transplantation, 2023
Recently, magnetic resonance imaging (MRI) has been developed as a widely available and noninvasive method for detecting and evaluating hepatic iron overload.
Nobuhiko Kurata, Masato Shizuku, Kanta Jobara, Yoji Ishizu, Masatoshi Ishigami, Yasuhiro Ogura   +5 more
doaj   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou, Guohang Shen, Lijing Si, Kaiyong Wang, Yang Chen, Ruoyan Wang, Yupei Dai   +6 more
wiley   +1 more source

Juvenile Hereditary Hemochromatosis: A Case Report [PDF]

Documenta Haematologica
Introduction: Hereditary hemochromatosis is an inherited condition where an excess of iron is absorbed from the diet, causing its accumulation in vital organs and subsequent organ damage.
Chhavi GOYAL, Omkar Kalidasrao CHOUDHARI, Disha SATYA, Priyanka SONI, Naveen GUPTA, Rajeev KASLIWAL, Rajat BHARGVA, Paresh SUKHANI, Hemant MALHOTRA   +8 more
doaj   +1 more source

Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major cause of cancer‐related mortality worldwide. Its poor clinical outcomes are largely attributed to late‐stage diagnosis and the limited accuracy of currently available diagnostic and prognostic biomarkers.
Jana Hamad, Hussein Fayyad‐Kazan, Fadi Abdel‐Sater   +2 more
wiley   +1 more source

A Late Presentation of a Fatal Disease: Juvenile Hemochromatosis

Case Reports in Medicine, 2013
Juvenile hemochromatosis is a rare and severe form of hereditary hemochromatosis. We report the case of a 39-year-old female who presented with heart failure and cirrhosis from previously unrecognized juvenile hemochromatosis.
Cynthia Cherfane, Pauline Lee, Leana Guerin, Kyle Brown   +3 more
doaj   +1 more source

Hereditary Hemochromatosis: Genetics, Pathogenesis, and Clinical Management

Annals of Hepatology, 2005
Recent findings have led to major advances in our understanding of genetics and pathophysiology of hereditary hemochromatosis. Many crucial genes and molecules have come to light, and the complex interrelationships between them are being studied. However,
Jacob Alexander, Kris V. Kowdley
doaj   +1 more source

Mechanistic Insights Into Hepatotoxicity‐Induced Liver Cirrhosis and Anemia: Iron Dysregulation, the Hepcidin–Ferroportin Axis, and Emerging Therapeutic Strategies

Organ Medicine, Volume 3, Issue 3, Page 171-185, September 2026.
Patients with alcohol‐associated liver cirrhosis or acetaminophen (APAP) toxicity frequently develop anemia with iron metabolism disturbances. Dysregulation of hepcidin–ferroportin signaling, along with inflammation, oxidative stress, hypoxia, impaired intestinal iron absorption, malnutrition, and gastrointestinal bleeding, contributes to anemia ...
Debabrata Dash, Raj Kumar Koiri
wiley   +1 more source

In-silico Molecular Analysis of Mutated Sequences of HFE1, HFE2, TFR2 and SLC40A1 causing Hemochromatosis Disease [PDF]

International Journal Bioautomation, 2011
Hemochromatosis is a disorder in iron metabolism that is characterized by excess iron absorption. There are two forms of hemochromatosis: primary hemochromatosis is caused by a problem with your genes.
Bilal Hussain, Hassan Tariq, Tayyaba Sultana, Shahid Mahboob, Tariq Niaz   +4 more
doaj