Results 91 to 100 of about 219,352 (339)

Presume It Not: True Causes in the Search for the Basis of Heredity [PDF]

open access: yes, 2017
Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature.
Novick, Aaron, Scholl, Raphael
core   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

open access: yesAdvanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu   +8 more
wiley   +1 more source

Severe immunodeficiency spectrum associated with NHEJ1 gene mutation: Cernunnos/XLF deficiency

open access: yesBiomédica: revista del Instituto Nacional de Salud
Cernunnos/XLF deficiency is a rare, severe combined immunodeficiency, inherited in an autosomal recessive pattern (OMIM number: 611290), related to the NHEJ1 gene.
Ana María Navarro   +5 more
doaj   +1 more source

Developmental Systems Theory as a Process Theory [PDF]

open access: yes, 2018
Griffiths and Russell D. Gray (1994, 1997, 2001) have argued that the fundamental unit of analysis in developmental systems theory should be a process – the life cycle – and not a set of developmental resources and interactions between those resources ...
Griffiths, Paul Edmund, Stotz, Karola
core  

Affine highest weight categories and affine quasihereditary algebras

open access: yes, 2014
Koenig and Xi introduced {\em affine cellular algebras}. Kleshchev and Loubert showed that an important class of {\em infinite dimensional} algebras, the KLR algebras $R(\Gamma)$ of finite Lie type $\Gamma$, are (graded) affine cellular; in fact, the ...
Kleshchev, Alexander S.
core   +1 more source

Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers

open access: yesAdvanced Science, EarlyView.
A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn   +5 more
wiley   +1 more source

Natural Selection of Paths in Networks [PDF]

open access: yes, 2011
We present a novel algorithm that exhibits natural selection of paths in a network. If each node and weighted directed edge has a unique identifier, a path in the network is defined as an ordered list of these unique identifiers.
Chrisantha Fernando   +3 more
core   +2 more sources

Exact Solution of an Evolutionary Model without Ageing

open access: yes, 1999
We introduce an age-structured asexual population model containing all the relevant features of evolutionary ageing theories. Beneficial as well as deleterious mutations, heredity and arbitrary fecundity are present and managed by natural selection.
A. F. R. de Toledo Piza   +23 more
core   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

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