Results 121 to 130 of about 61,249 (214)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms. [PDF]

Proc Biol Sci
Tratkiewicz K, Gąsiorowski L.
europepmc   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Gene variants associated with skin barrier dysfunction in atopic dermatitis: a systematic review and meta-analysis. [PDF]

Rev Paul Pediatr
Cordeiro PL, Moraes CGF, Ferrari LP, Rosário Filho NA.   +3 more
europepmc   +1 more source

Diagnosing Systemic Mastocytosis: State of the Art

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

The science and legacies of Ronald Phillips: A brief perspective. [PDF]

Plant Genome
Flavell RB.
europepmc   +1 more source

Clinical and Genetic Characterization of 269 Patients With Suspected Inherited Platelet Disorders: The Padua Monocentric Experience

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari, Daniela Regazzo, Antonella Bertomoro, Anna Cerbo, Alessandro Galbiati, Elisabetta Cosi, Paolo Simioni   +6 more
wiley   +1 more source

"Helping to Bridge the Gap Between Genetics and Development:ˮ Julian Huxley, Early 20th Century Oxford Biology, and the Epigenetic Origins of Animal Characters. [PDF]

J Hist Biol
Bernhardt-Radu S.
europepmc   +1 more source

Make Social Media Social Again: How Platform Interoperability Can Fix Social Media and Future‐Proof Democracy

Journal of Management Studies, EarlyView.
Abstract This essay argues that social media document (rather than fuel) the decline of political democracy while helping revive organizational democracy, including through ‘decentralized autonomous organizations’ (DAOs). Yet, despite giving everyone a voice and the ability to organize across borders, social media could over‐concentrate power if, in ...
J.P. Vergne
wiley   +1 more source

The Transformation Experiment of Frederick Griffith II: Inclusion of Cellular Heredity for the Creation of Novel Microorganisms. [PDF]

Bioengineering (Basel)
Müller GA.
europepmc   +1 more source