Results 111 to 120 of about 108,348 (283)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

The Genetic Parameters for Average Daily Gain and Kleiber Ratio in Charolaise Breed

Scientific Papers Animal Science and Biotechnologies
The objective of this paper was to estimate the genetic parameters for average daily gain from 200 days to 365 days and Kleiber ratio in Charolaise breed with maternal animal model. The data were represented by 582 records of Charolaise cattle breed. The
Rodica Ștefania Pelmuș, Mircea Cătălin Rotar, Mihail Alexandru Gras, Cristina Van   +3 more
doaj  

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.

PLoS Genetics
Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer's disease (LOAD) and provides a rationale for identifying genetic factors associated with disease susceptibility. While
Shiying Liu, William S Bush, Rufus O Akinyemi, Goldie S Byrd, Allison Mercedes Caban-Holt, Farid Rajabli, Christiane Reitz, Brian W Kunkle, Giuseppe Tosto, Jeffery M Vance, Margaret Pericak-Vance, Jonathan L Haines, Scott M Williams, Dana C Crawford   +13 more
doaj   +1 more source

Quantile-specific heritability of monocyte chemoattractant protein-1, and relevance to rs1024611-disease interactions [PDF]

, 2021
Paul T. Williams
openalex   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Heritability [PDF]

, 2011
  +5 more sources

Heritability [PDF]

, 2019
  +4 more sources

Syndrome‐specific and familial imaging traits in juvenile absence epilepsy

Epilepsia, EarlyView.
Abstract Objective Juvenile absence epilepsy (JAE) is an idiopathic generalized epilepsy characterized by absences, generalized tonic–clonic seizures, and cognitive difficulties. In contrast to juvenile myoclonic epilepsy (JME), where distinct functional and structural brain alterations are well established, it remains unclear whether comparable ...
Fenglai Xiao, Lorenzo Caciagli, Luisa Delazer, Sjoerd Vos, Karin Trimmel, Louis Andre Van Graan, Marine Fleury, Lawrence Binding, Davide Giampiccolo, Dominic Heaney, Sanjeev Rajakulendran, Maria Centeno, Josemir W. Sander, John S. Duncan, Matthias J. Koepp, Britta Wandschneider   +15 more
wiley   +1 more source

Heritability of the Human Craniofacial Complex

, 2015
Maja Šešelj, Dana L. Duren, Richard J. Sherwood   +2 more
openalex   +2 more sources