Results 111 to 120 of about 355,175 (361)

Reliable heritability estimation using sparse regularization in ultrahigh dimensional genome-wide association studies

BMC Bioinformatics, 2019
Background Data from genome-wide association studies (GWASs) have been used to estimate the heritability of human complex traits in recent years. Existing methods are based on the linear mixed model, with the assumption that the genetic effects are ...
Xin Li, Dongya Wu, Yue Cui, Bing Liu, Henrik Walter, Gunter Schumann, Chong Li, Tianzi Jiang   +7 more
doaj   +1 more source

MicrobeDiscover: A Knowledge Graph–Enabled AI Framework for Identifying Microbes for Inorganic Nanomaterial Biosynthesis

Advanced Science, EarlyView.
Microbial synthesis of nanomaterials (NMs) is eco‐friendly, but the screening of microorganisms is limited by inefficient traditional methods (currently only involving∽400 microorganisms/90 NMs). We propose AI framework MicrobeDiscover, integrating a knowledge graph of microbe‐NM interactions.
Ludi Wang, Hexing Han, Yufeng Liu, Zhiyuan Ning, Yujie Ma, Haidan Wang, Jinling Xu, Qiansheng Huang, Wenjuan Cui, Yuanchun Zhou, Yang Gao, Bin Wang, Yi Du   +12 more
wiley   +1 more source

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

Nature Genetics, 2019
SNP-heritability is a fundamental quantity in the study of complex traits. Recent studies have shown that existing methods to estimate genome-wide SNP-heritability can yield biases when their assumptions are violated.
Kangcheng Hou, Kathryn S. Burch, Arunabha Majumdar, Huwenbo Shi, Nicholas Mancuso, Yue Wu, S. Sankararaman, B. Pasaniuc   +7 more
semanticscholar   +1 more source

De Gustibus Est Disputandum: The role of agricultural and applied economists in an era of behavior change initiatives and endogenous preferences

American Journal of Agricultural Economics, EarlyView.
Abstract Popular society increasingly questions preferences that drive many resource allocations and production decisions, with many groups actively seeking to alter those preferences to achieve changes to resource use. Agricultural and applied economists, who are already equipped with excellent technical skills to undertake consumer preference and ...
Brian E. Roe
wiley   +1 more source

Variability and heritability of some onion (Allium cepa L.) characteristics of parental forms, F1 hybrids and F2 generation

Acta Agrobotanica, 2013
The object of the studies in 1977 was a population of 15 F1 hybrids, 11 F2 progenies and 16 parental forms (8 male-sterile A lines and 8 inbred C lines - Table 2).
Roch W. Doruchowski
doaj   +1 more source

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Nature Genetics, 2022
Pierrick Wainschtein, D. Jain, Zhili Zheng, Stella Diane Wenjian Jennifer Jenna C. Adolfo Margaret Me Aslibekyan Becker Bi Brody Carlson Correa Du Ferna, S. Aslibekyan, D. Becker, W. Bi, J. Brody, Jenna C. Carlson, A. Correa, M. Du, L. Fernández-Rhodes, Kendra R. Ferrier, M. Graff, Xiuqing Guo, Jiang He, N. Heard-Costa, H. Highland, J. Hirschhorn, C. Howard-Claudio, C. Isasi, Rebecca Jackson, Jicai Jiang, R. Joehanes, A. Justice, R. Kalyani, S. Kardia, E. Lange, M. LeBoff, Seunggeun Lee, Xihao Li, Zilin Li, E. Lim, Danyu Lin, Xihong Lin, Simin Liu, Yingchang Lu, J. Manson, Lisa W. Martin, Caitlin P. McHugh, Julie Mikulla, S. Musani, M. Ng, D. Nickerson, Nicholette D. Palmer, James Perry, U. Peters, Michael H. Preuss, Q. Qi, L. Raffield, L. Rasmussen-Torvik, A. Reiner, Emily M. Russell, C. Sitlani, Jennifer A. Smith, Cassandra N. Spracklen, Tao Wang, Zhe Wang, J. Wessel, Hanfei Xu, M. Yaser, Sachiko Yoneyama, K. Young, Jingwen Zhang, Xinruo Zhang, Hufeng Zhou, Xiaofeng Zhu, S. Zoellner, Namiko Gonçalo Francois Laura Alvaro Seth Peter Pramod De Abe Abecasis Aguet Almasy Alonso Ament Anderson An, Namiko Abe, G. Abecasis, F. Aguet, L. Almasy, Álvaro Alonso, S. Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, K. Ardlie, D. Arking, Allison Ashley-Koch, T. Assimes, Paul W. Auer, D. Avramopoulos, N. Ayas, A. Balasubramanian, J. Barnard, K. Barnes, R. G. Barr, E. Barron-Casella, L. Barwick, Terri L Beaty, Gerald Beck, L. Becker, Rebecca Beer, A. Beitelshees, E. Benjamin, Takis Benos, Marcos Bezerra, L. Bielak, Joshua Bis, Thomas Blackwell, J. Blangero, D. Bowden, Russell P Bowler, U. Broeckel, J. Broome, Deborah Brown, Karen L. Bunting, E. Burchard, Carlos Bustamante, Erin Buth, B. Cade, J. Cardwell, V. Carey, J. Carrier, April P. Carson, C. Carty, R. Casaburi, Juan P. Casas Romero, James M. Casella, P. Castaldi, M. Chaffin, Christy Chang, Yi-Cheng Chang, S. Chavan, Bo-Juen Chen, Wei-Min Chen, Michael Cho, S. Choi, Lee-Ming Chuang, R. Chung, C. Clish, S. Comhair, M. Conomos, E. Cornell, Carolyn Crandall, J. Crapo, J. Curran, J. Curtis, B. Custer, C. Damcott, D. Darbar, S. David, Colleen Davis, M. Daya, L. de las Fuentes, P. D. de Vries, Michael R. DeBaun, R. Deka, D. Demeo, Scott Devine, H. Dinh, H. Doddapaneni, Qing Duan, Shannon Dugan-Perez, R. Duggirala, J. P. Durda, S. Dutcher, Charles B. Eaton, L. Ekunwe, A. El Boueiz, L. Emery, S. Erzurum, Charles Farber, J. Farek, T. Fingerlin, M. Flickinger, N. Franceschini, C. Frazar, Mao Fu, Stephanie M. Fullerton, L. Fulton, S. Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery L S Gass, Heather Geiger, B. Gelb, M. Geraci, S. Germer, R. Gerszten, Auyon J. Ghosh, Richard Gibbs, Christopher R. Gignoux, M. Gladwin, David E. Glahn, S. Gogarten, Daoping Gong, H. Goring, S. Graw, K. J. Gray, Daniel Grine, Colin Gross, C. Gu, Y. Guan, N. Gupta, David M. Haas, J. Haessler, Michael Hall, Yi Han, P. Hanly, Daniel Harris, N. Hawley, Benjamin D. Heavner, David M. Herrington, C. Hersh, Bertha A. Hidalgo, J. Hixson, B. Hobbs, J. Hokanson, Elliott Hong, Karin Hoth, C. Hsiung, Jianhong Hu, Y. Hung, H. Huston, C. Hwu, M. Irvin, C. Jaquish, J. Johnsen, Andrew D. Johnson, Craig Johnson, R. Johnston, Kimberly Jones, H. M. Kang, R. Kaplan, Shannon Kelly, E. Kenny, Michael D. Kessler, Alyna T Khan, Ziad M. Khan, Wonji Kim, J. Kimoff, G. Kinney, B. Konkle, Holly Kramer, C. Lange, Jiwon Lee, Sandra Lee, Wen-Jane Lee, J. Lefaive, David Levine, D. Levy, J. Lewis, Xiaohui Li, Yun Li, Henry J. Lin, Honghuang Lin, Yongmei Liu, Yu Liu, K. Lunetta, James Luo, U. Magalang, Michael P. Mahaney, B. Make, A. Manichaikul, A. Manning, Melissa Marton, S. Mathai, Susanne May, P. McArdle, Sean McFarland, Daniel McGoldrick, B. McNeil, H. Mei, J. Meigs, Vipin Menon, L. Mestroni, G. Metcalf, D. Meyers, E. Mignot, N. Min, Mollie A Minear, R. Minster, M. Moll, Z. Momin, M. Montasser, C. Montgomery, D. Muzny, J. Mychaleckyj, Girish N. Nadkarni, Rakhi Naik, T. Naseri, P. Natarajan, S. Nekhai, Sarah C. Nelson, Bonnie Neltner, C. Nessner, Osuji Nkechinyere, T. O'Connor, H. Ochs-Balcom, Geoffrey O. Okwuonu, Allan Pack, David T. Paik, J. Pankow, G. Papanicolaou, Cora Parker, G. Peloso, J. Peralta, Marco V. Perez, P. Peyser, Lawrence S. Phillips, Jacob Pleiness, T. Pollin, Wendy S. Post, Julia Powers Becker, M. Boorgula, P. Qasba, D. Qiao, Zhaohui Qin, N. Rafaels, M. Rajendran, D. Rao, A. Ratan, Robert Reed, C. Reeves, M. Reupena, Kenneth M. Rice, R. Robillard, N. Robine, C. Roselli, I. Ruczinski, Alexi Runnels, Pamela H. Russell, S. Ruuska, K. Ryan, E. Sabino, D. Saleheen, S. Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, V. Sankaran, J. Santibanez, K. Schwander, D. Schwartz, F. Sciurba, C. Seidman, J. Seidman, V. Sheehan, S. Sherman, Amol C. Shetty, A. Shetty, W. Sheu, Brian H. Silver, E. Silverman, Robert Skomro, A. Smith, Josh Smith, Tanja Smith, S. Smoller, B. Snively, M. Snyder, T. Sofer, N. Sotoodehnia, A. Stilp, G. Storm, E. Streeten, J. Su, Y. Sung, Jody Sylvia, Adam A. Szpiro, D. Taliun, Hua Tang, M. Taub, K. Taylor, M. Taylor, Simeon I. Taylor, M. Telen, T. Thornton, M. Threlkeld, Lesley Tinker, D. Tirschwell, S. Tishkoff, Hemant Tiwari, Catherine Tong, R. Tracy, Michael Tsai, Dhananjay Vaidya, D. J. Van Den Berg, Peter Vandehaar, S. Vrieze, Tarik Walker, R. Wallace, A. Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, K. Watson, Jenn Watt, D. Weeks, J. Weinstock, Scott T. Weiss, L. Weng, C. Willer, Kayleen Williams, L. Williams, Carla Wilson, James G. Wilson, L. Winterkorn, Q. Wong, Joseph Wu, Huichun Xu, Ivana V. Yang, Ketian Yu, S. Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, M. Zody, L. Cupples, A. Shadyab, B. McKnight, Ben Shoemaker, B. Mitchell, B. Psaty, C. Kooperberg, Ching‐Ti Liu, C. Albert, D. Roden, D. Chasman, D. Darbar, D. Lloyd‐Jones, D. Arnett, E. Regan, E. Boerwinkle, J. Rotter, J. O’Connell, L. Yanek, M. de Andrade, M. Allison, Merry-Lynn N. McDonald, M. Chung, M. Fornage, Nathalie Chami, N. Smith, P. Ellinor, R. Vasan, R. Mathias, R. Loos, S. Rich, S. Lubitz, S. Heckbert, S. Redline, Xiuqing Guo, Y. D. Chen, C. Laurie, Ryan D. Hernandez, S. McGarvey, M. Goddard, Cathy C. Laurie, K. North, L. Lange, B. Weir, L. Yengo, Jian Yang, P. Visscher   +458 more
semanticscholar   +1 more source

Rangewide responses of Mimulus cardinalis to an extreme heat event

American Journal of Botany, EarlyView.
Abstract Premise Extreme events are an understudied aspect of ongoing anthropogenic climate change that could play a disproportionate role in the threat that rapid environmental shifts pose to natural populations. Methods We exposed plants originating from seeds that were harvested before (ancestors) and after (descendants) multiple extreme heat events
Lucas J. Albano, Robin A. Bingham, Sulma Correa, Catherine G. Laufenberg, Cristina Payst, Christopher D. Muir, Seema Nayan Sheth   +6 more
wiley   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

What Is the Heritability of Periodontitis? A Systematic Review

Journal of dentistry research, 2019
The aim of this study was to systematically appraise the existing literature on the yet-unclear heritability of gingivitis and periodontitis. This review was conducted following the PRISMA guidelines.
Luigi Nibali, J. Bayliss-Chapman, S. Almofareh, Y. Zhou, K. Divaris, Alexandre R. Vieira   +5 more
semanticscholar   +1 more source

Schizophrenia Genetics Modulates Clinical Depressive Features

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.
Alessandro Serretti, Daniel Souery, Siegfried Kasper, Joseph Zohar, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Raffaele Ferri, Giuseppe Fanelli, Chiara Fabbri, Raffaella Zanardi, Francesco Benedetti, Bernhard T. Baune, Julien Mendlewicz   +13 more
wiley   +1 more source