Results 91 to 100 of about 152,085 (301)

High heritability is compatible with the broad distribution of set point viral load in HIV carriers.

PLoS Pathogens, 2015
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Sebastian Bonhoeffer, Christophe Fraser, Gabriel E Leventhal   +2 more
doaj   +1 more source

HERITABILITY OF AEROBIC POWER OF INDIVIDUALS IN NORTHEAST BRAZIL

, 2014
The objective of this study was to evaluate the genetic and environmental contribution to variation in aerobic power in monozygotic (MZ) and dizygotic (DZ) twins.
MV Oliveira, PMS Dantas, L Alonso, EC Souza, LFE do Nascimento   +4 more
core   +1 more source

Short communication: heritability estimation of birth weight of swamp buffalo in Sabah, Malaysia

, 2020
Data on birth weight of Swamp buffalo calves that were born between 2015 and 2017 were collected and analyzed for this study. The objective was to estimate the effect of heritability and to evaluate the influence of environmental factors on the birth ...
Zulkafli, H. S., Saad, M. Zamri, Goh, Y. M., Soh, S. S., Salisi, M. S., Yahaya, M. S.   +5 more
core   +1 more source

The Collective Power of Bacteria as a Blueprint for Emergent Intelligence

Advanced Intelligent Systems, EarlyView.
Small cells, powerful collectives. Bacteria demonstrate how sophisticated behaviors can emerge from many simple individuals working together. We explore the remarkable world of bacterial communities and the mechanisms that underpin their complex emergent behaviors, enabling impressive adaptability, robustness, and responsiveness to changing ...
Johanna A. Blee, Thomas E. Gorochowski, Sabine Hauert   +2 more
wiley   +1 more source

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen, Ulrik Kristoffer Stoltze, Pernille Axél Gregersen, Marianne Hoffmann, Morten Lyng Høgild, Mette Klarskov Andersen, Lise Barlebo Ahlborn, Lisa Lyngsie Hjalgrim, Karin A. W. Wadt   +8 more
wiley   +1 more source

SNP-based heritability estimation using a Bayesian approach

Animal, 2013
Heritability is a central element in quantitative genetics. New molecular markers to assess genetic variance and heritability are continually under development. The availability of molecular single nucleotide polymorphism (SNP) markers can be applied for
K. Krag, L.L. Janss, M.M. Shariati, P. Berg, A.J. Buitenhuis   +4 more
doaj   +1 more source

Haplotype heritability mapping method uncovers missing heritability of complex traits [PDF]

, 2018
We propose a novel approach to analyze genomic data that incorporates haplotype information for detecting rare variants within a regional heritability mapping framework.
Ricardo Pong-Wong, Masoud Shirali, Sara A. Knott, Haley, Chris S., Pau Navarro, Shirali, Masoud; id_orcid, Knott, Sara, Pong-Wong, Ricardo, Shirali, Masoud, Knott, Sara A., Chris S. Haley, Pong-Wong, Ricardo; id_orcid, Navarro, Pau; id_orcid, Navarro, Pau, Haley, Christopher   +14 more
core   +1 more source

Genetic Variation in ADHD‐Related Risk Genes in an Indigenous Population of the Amazon

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Attention‐Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder; however, its genetic architecture remains poorly explored in Indigenous populations. This study aimed to analyze and characterize genetic variation in 11 genes (ADGRL3, CDH8, DCC, DUSP6, FOXP1, FOXP2, MEF2C, PCDH7, SEMA6D, SORCS3, and ST3GAL3 ...
Hirlesson Paixão de Matos, Natasha Monte, Kaio Evandro Cardoso Aguiar, Rita de Cássia Calderaro, Aline Pasquini Santos, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐Dos‐Santos, Sandro José De Souza, Ândrea Ribeiro‐Dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista Dos Santos, Ney Pereira Carneiro Dos Santos   +11 more
wiley   +1 more source

Reliable heritability estimation using sparse regularization in ultrahigh dimensional genome-wide association studies

BMC Bioinformatics, 2019
Background Data from genome-wide association studies (GWASs) have been used to estimate the heritability of human complex traits in recent years. Existing methods are based on the linear mixed model, with the assumption that the genetic effects are ...
Xin Li, Dongya Wu, Yue Cui, Bing Liu, Henrik Walter, Gunter Schumann, Chong Li, Tianzi Jiang   +7 more
doaj   +1 more source