Results 31 to 40 of about 355,175 (361)
Functionally-informed fine-mapping and polygenic localization of complex trait heritability
Nature Genetics, 2019 Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-mapping accuracy by leveraging functional annotations across the entire genome—not just genome-wide ...
O. Weissbrod +13 more
semanticscholar +1 more source
Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits.
PLoS ONE, 2013 For most complex traits, results from genome-wide association studies show that the proportion of the phenotypic variance attributable to the additive effects of individual SNPs, that is, the heritability explained by the SNPs, is substantially less than
Sven Stringer +4 more
doaj +1 more source
Depigmented wing patch size is a condition-dependent indicator of viability in male collared flycatchers [PDF]
, 2003 Honesty of sexual advertisement is thought to be the result of signalling costs. Because production costs of depigmented plumage patches are probably very low, their role as honest signals of individual quality has been questioned. Costs of bearing these
Garamszegi, László Zsolt +2 more
core +1 more source
Jurnal Peternakan Indonesia, 2017 This study is proposed to determine the heritability of growth traits of Simmental cattle in BPTU-HPT Padang Mengatas, West Sumatra. Data were collected by observations and measurements of the cattle in the field, completed by the secondary data from ...
Dino Eka Putra +4 more
doaj +1 more source
Quantifying the heritability of belief formation
Scientific Reports, 2022 Individual differences in behaviour, traits and mental-health are partially heritable. Traditionally, studies have focused on quantifying the heritability of high-order characteristics, such as happiness or education attainment.
Valentina Vellani +4 more
doaj +1 more source
bioRxiv, 2016 Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional ...
Jie Zheng +20 more
semanticscholar +1 more source
Quantifying missing heritability at known GWAS loci.
PLoS Genetics, 2013 Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs.
Alexander Gusev +12 more
doaj +1 more source
Genetics of callous-unemotional behavior in children.
PLoS ONE, 2013 Callous-unemotional behavior (CU) is currently under consideration as a subtyping index for conduct disorder diagnosis. Twin studies routinely estimate the heritability of CU as greater than 50%. It is now possible to estimate genetic influence using DNA
Essi Viding +7 more
doaj +1 more source
Multivariate Survival Mixed Models for Genetic Analysis of Longevity Traits [PDF]
, 2014 A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications.
Labouriau, Rodrigo +2 more
core +2 more sources
Trait heritability in major transitions
BMC Biology, 2018 Background Increases in biological complexity and the origins of life’s hierarchical organization are described by the “major transitions” framework.
Matthew D. Herron +2 more
doaj +1 more source