Results 61 to 70 of about 251,536 (320)

Genetic parameters for milk somatic cell score and relationships with production traits in primiparous dairy sheep [PDF]

, 2007
A total of 13,066 first-lactation test-day records of 2,277 Valle del Belice ewes from 17 flocks were used to estimate genetic parameters for somatic cell scores (SCS) and milk production traits, using a repeatability test-day animal model.
Bovenhuis, H., Finocchiaro, R., Portolano, B., Riggio, V., van Kaam, J. B. C. H. M.   +4 more
core   +3 more sources

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Estimation of heritability and genetic advance for various metric traits in seven F2 populations of bread wheat (Triticum aestivum L.) [PDF]

Journal of Agricultural Sciences (Belgrade), 2016
Heritability estimates provide information about the traits that are transmitted from parents to their offsprings and it has a crucial role in selection criteria to improve grain yield.
Saleem Babar, Khan Abdus Salam, Shahzad Muhammad Talha, Ijaz Fahid   +3 more
doaj   +1 more source

Accurate Liability Estimation Improves Power in Ascertained Case Control Studies

, 2015
Linear mixed models (LMMs) have emerged as the method of choice for confounded genome-wide association studies. However, the performance of LMMs in non-randomly ascertained case-control studies deteriorates with increasing sample size.
AL Price, AL Price, C Lippert, C Widmer, Christoph Lippert, D Golan, D Welter, Dan Geiger, David Heckerman, DJ Balding, ER Dempster, J Listgarten, J Yang, J Yang, J Yang, LA Hindorff, LC Tsoi, M Fakiola, N Fusi, N Patterson, N Zaitlen, N Zaitlen, Omer Weissbrod, S Sawcer, S Wright, SH Lee, X Zhou   +26 more
core   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles [PDF]

, 2009
Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction.
AA Hoffmann, B Zwaan, C Mühlhäuser, CW Fox, D Houle, D J Hosken, D Reznick, DA Dewsbury, DA Roff, DA Roff, DJ Hodgson, DJ Hosken, DJ Hosken, DS Falconer, E A Brown, FJ Messina, G Arnqvist, GA Schwarzenbach, GJ Kenagy, HS Crudgington, IT MacBean, J Hunt, J Hunt, JS Kotiaho, L Gay, L Partridge, LW Simmons, LW Simmons, M Ackermann, M Edvardsson, M Edvardsson, M Gasser, M Lynch, M Tatar, MD Tuttle, ME Czesak, MH Gromko, MJG Gage, MJG Gage, MR Rose, MT Siva-Jothy, N Wedell, NG Prasad, OY Martin, OY Martin, P E Eady, P Eady, PE Eady, R Thornhill, R Vasudev, S Paukku, S Pitnick, S Wigby, S-B Horng, T Burk, T Chapman, T Clutton-Brock, T Miyatake, T Price, T Tregenza, TA Mousseau, UM Savalli, UM Savalli, UM Savalli, WA Becker, WA Van Voorhies, WG Hill, WJ Bailey, WU Blanckenhorn, Y Qi   +69 more
core   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, EarlyView.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Heritability estimates of body size in fetal life and early childhood.

PLoS ONE, 2012
BackgroundThe objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins.MethodsThis study was ...
Dennis O Mook-Kanamori, Catharina E M van Beijsterveldt, Eric A P Steegers, Yurii S Aulchenko, Hein Raat, Albert Hofman, Paul H Eilers, Dorret I Boomsma, Vincent W V Jaddoe   +8 more
doaj   +1 more source

How to read “heritability” in the recipe approach to natural selection [PDF]

, 2013
There are two ways evolution by natural selection (ENS) is conceptualized in the literature. One provides a ‘recipe’ for ENS incorporating three ingredients: variation, differences in fitness and heritability.
Bourrat, Pierrick
core