Results 61 to 70 of about 355,175 (361)

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

SNP-based and pedigree-based estimation of heritability and maternal effect for body weight traits in an F2 intercross between Landrace and Jeju native black pigs

Journal of Animal Reproduction and Biotechnology, 2016
Growth traits, such as body weight, directly influence productivity and economic efficiency in the swine industry. In this study, we estimate heritability for body weight traits usinginformation from pedigree and genome-wide single nucleotide ...
Hee-Bok Park, Sang-Hyun Han, Jae-Bong Lee, Sang-Geum Kim, Yong-Jun Kang, Hyun-Sook Shin, Sang-Min Shin, Ji-Hyang Kim, Jun-Kyu Son, Kwang-Soo Baek, Sang-Rae Cho, In-Cheol Cho   +11 more
doaj   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Exploring the Link Between Additive Heritability and Prediction Accuracy From a Ridge Regression Perspective

Frontiers in Genetics, 2020
Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts for the many ...
Arthur Frouin, Claire Dandine-Roulland, Morgane Pierre-Jean, Jean-François Deleuze, Jean-François Deleuze, Christophe Ambroise, Edith Le Floch   +6 more
doaj   +1 more source

Relative abundance data can misrepresent heritability of the microbiome

Microbiome, 2023
Background Host genetics can shape microbiome composition, but to what extent it does, remains unclear. Like any other complex trait, this important question can be addressed by estimating the heritability (h 2 ) of the microbiome—the proportion of ...
Marjolein Bruijning, Julien F. Ayroles, Lucas P. Henry, Britt Koskella, Kyle M. Meyer, C. Jessica E. Metcalf   +5 more
doaj   +1 more source

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies [PDF]

, 2019
Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted
Gilles de la Tourette GWAS Replication Initiative, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Tourette Association of America International Consortium for Genetics, Tourette International Collaborative Genetics Study, Woods, Douglas W.   +4 more
core   +1 more source

Genetic Covariance Structure of Reading, Intelligence and Memory in Children [PDF]

, 2009
This study investigates the genetic relationship among reading performance, IQ, verbal and visuospatial working memory (WM) and short-term memory (STM) in a sample of 112, 9-year-old twin pairs and their older siblings.
A Baddeley, A Baddeley, A Baddeley, A Baddeley, A Brooks, A Gevins, A Zumberge, AC Kercher, AJ Marlow, B Byrne, BF Pennington, Cito, D Boomsma, D Evans, D Wechsler, DI Boomsma, DI Boomsma, Dorret I. Boomsma, DVM Bishop, Hilleke E. Hulshoff Pol, HL Swanson, HL Swanson, HL Swanson, HL Swanson, J Gayán, JF Démonet, Jiska S. Peper, JJ Hottenga, JM Jansma, JS Peper, KE Stanovich, LA Thompson, LR Cardon, M Alarcón, M Leeuwen Van, M Neale, MA Ferreira, Marieke van Leeuwen, MI McCarthy, MJ Snowling, R Cohen-Mimran, R Olson, R Plomin, RB Livingston, RD Tiu Jr, RD Tiu Jr, RJ Sternberg, S Sluis Van der, SA Petrill, SE Gathercole, SE Gathercole, SJ Wadsworth, SJ Wadsworth, Stéphanie M. van den Berg, TS Price, VS Knopik, X Ding   +56 more
core   +5 more sources

Evaluating and improving heritability models using summary statistics

Nature Genetics, 2019
There is currently much debate regarding the best model for how heritability varies across the genome. The authors of GCTA recommend the GCTA-LDMS-I model, the authors of LD Score Regression recommend the Baseline LD model, and we have recommended the ...
D. Speed, J. Holmes, D. Balding
semanticscholar   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source