Results 61 to 70 of about 99,486 (214)
Informant Discrepancies and the Heritability of Antisocial Behavior: A Meta-Analysis [PDF]
arXiv, 2013 Antisocial behavior, which includes both aggressive and delinquent activities, is the opposite of prosocial behavior. Researchers have studied the heritability of antisocial behavior among twin and non-twin sibling pairs from behavioral ratings made by parents, teachers, observers, and youth.
arxiv
Narrowing the gap on heritability of common disease by direct estimation in case-control GWAS [PDF]
arXiv, 2013 One of the major developments in recent years in the search for missing heritability of human phenotypes is the adoption of linear mixed-effects models (LMMs) to estimate heritability due to genetic variants which are not significantly associated with the phenotype.
arxiv
High heritability does not imply accurate prediction under the small additive effects hypothesis [PDF]
arXiv, 2020 Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts for the many small contributions of SNPs in the explanation of a phenotype.
arxiv
BMC Bioinformatics, 2019 Background Data from genome-wide association studies (GWASs) have been used to estimate the heritability of human complex traits in recent years. Existing methods are based on the linear mixed model, with the assumption that the genetic effects are ...
Xin Li +7 more
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A Robust and Unified Framework for Estimating Heritability in Twin Studies using Generalized Estimating Equations [PDF]
arXiv, 2017 The development of a complex disease is an intricate interplay of genetic and environmental factors. "Heritability" is defined as the proportion of total trait variance due to genetic factors within a given population. Studies with monozygotic (MZ) and dizygotic (DZ) twins allow us to estimate heritability by fitting an "ACE" model which estimates the ...
arxiv
The Heritable Effects of Nanotoxicity
Nanomedicine, 2014 The widespread entry of nanomaterials into manifold life fields posed serious concerns on environmental health and safety issues. Potential adverse effects of nanoparticles (NPs) are continuously faced using in vitro cell systems and by mean of cell and molecular biology tools, several mechanisms have been found beyond their toxicity. The evaluation of
Tortiglione, Claudia
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Acta Agrobotanica, 2013 The object of the studies in 1977 was a population of 15 F1 hybrids, 11 F2 progenies and 16 parental forms (8 male-sterile A lines and 8 inbred C lines - Table 2).
Roch W. Doruchowski
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Heritability estimation in high dimensional linear mixed models [PDF]
arXiv, 2014 Motivated by applications in genetic fields, we propose to estimate the heritability in high dimensional sparse linear mixed models. The heritability determines how the variance is shared between the different random components of a linear mixed model.
arxiv
The curse of the missing heritability [PDF]
Frontiers in Genetics, 2013 Since “the case of the missing heritability” was highlighted 5 years ago (Maher, 2008), scientists have been investigating various possible explanations for this issue (Manolio et al., 2009; Slatkin, 2009; Eichler et al., 2010; Zuk et al., 2012). Recently, Bloom et al.
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Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.
Frontiers in Physiology, 2016 INTRODUCTIONThe resting ECG is the most commonly used tool to assess cardiac electrophysiology. Previous studies have estimated heritability of ECG parameters based on these snapshots of the cardiac electrical activity.
Emily C Hodkinson +15 more
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