Results 81 to 90 of about 355,175 (361)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Quantitative genetics of maize (Zea mays L.) during seedling establishment under cool conditions : a thesis presented in partial fulfillment of the requirements for the degree of Master of Agricultural Science in Plant Science at Massey University [PDF]

, 1992
Two experiments were conducted to study cool tolerance in maize (Zea mays L.). The first experiment was carried out under controlled environment to evaluate several genotypes from five synthetic populations which are currently being used to develop ...
Chozin, Mohammad
core  

The Heritability of Behavior: A Meta-analysis.

Journal of Heredity, 2019
The contribution of genetic variation to phenotypes is a central factor in whether and how populations respond to selection. The most common approach to estimating these influences is via the calculation of heritabilities, which summarize the ...
N. Dochtermann, Tori Schwab, Monica Anderson Berdal, Jeremy Dalos, Raphaël Royauté   +4 more
semanticscholar   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Heritability in frontotemporal tauopathies

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Exploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide ...
Shelley L. Forrest, Glenda M. Halliday, Heather McCann, Andrew B. McGeachie, Ciara V. McGinley, John R. Hodges, Olivier Piguet, John B. Kwok, Maria G. Spillantini, Jillian J. Kril   +9 more
doaj   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Genetics and Economic Mobility [PDF]

, 2008
Presents a literature review on the link between genetic traits, such as cognitive skills, health, mental health, personality, and appearance, and academic and economic success.
Jessica Kronstadt
core  

Heritability of pain catastrophizing and associations with experimental pain outcomes: a twin study [PDF]

, 2015
This study used a twin paradigm to examine genetic and environmental contributions to pain catastrophizing and the observed association between pain Catastrophizing and cold-pressor task (CPT) outcomes. Male and female monozygotic (n = 206) and dizygotic
Afari, Afari, Angst, Belfer, Boomsma, Busjahn, Crombez, Diatchenko, Finan, Gatchel, George, Goubert, Goubert, Horsham, Hur, Jensen, Karsdorp, Kato, Keefe, Kendler, Kozak, Kraljevic, Leeuw, McGue, Mogil, Nielsen, Norbury, Osman, Pavlakovic, Quartana, Rijsdijk, Seminowicz, Smeets, Stein, Strachan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Sullivan, Trost, Trost, Turk, Turner, Van Damme, Van Damme, Van Damme, Vassend, Verhoeven, Vervoort, Vervoort, Vervoort, Weissman-Fogel, Wilson   +54 more
core   +2 more sources

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

Nature Genetics, 2015
We propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing data. We demonstrate using simulations based on whole-genome sequencing data that ∼97% and ∼68% of variation at ...
Jian Yang, A. Bakshi, Zhihong Zhu, G. Hemani, A. Vinkhuyzen, S. Lee, M. Robinson, J. Perry, I. Nolte, Jana V. van Vliet-Ostaptchouk, H. Snieder, T. Esko, L. Milani, R. Mägi, A. Metspalu, A. Hamsten, P. Magnusson, N. Pedersen, E. Ingelsson, N. Soranzo, M. Keller, N. Wray, M. Goddard, P. Visscher   +23 more
semanticscholar   +1 more source

Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility

Advanced Science, EarlyView.
This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin, Xiaodian Cai, Zhanming Zhong, Tingting Li, Xinyou Chen, Wondossen Ayalew, Zhiting Xu, Chen Wei, Xiaoke Zhang, Hong Cheng, Zhenyang Zhang, Xuehua Li, Yongjie Tang, Siqian Chen, Jun Zhou, Jinglei Si, Xibo Wu, Chao Ning, Qishan Wang, Yuchun Pan, Yahui Gao, Jiaqi Li, Ying Yu, Zhe Zhang, Yunxiang Zhao, Lingzhao Fang, Zhe Zhang   +26 more
wiley   +1 more source