Results 81 to 90 of about 99,486 (214)
Journal of Lipid Research, 2019 Heritability of LPA allele, apo(a) isoform sizes, and isoform-associated lipoprotein(a) [Lp(a)] levels was studied in 82 Caucasian and African-American families with two parents and two children (age: 6–74 years).
Byambaa Enkhmaa +4 more
doaj
Identifying Heritable Communities of Microbiome by Root-Unifrac and Wishart Distribution [PDF]
arXiv, 2018 We introduce a method to identify heritable microbiome communities when the input is a pairwise dissimilarity matrix among all samples. Current methods target each taxon individually and are unable to take advantage of their phylogenetic relationships.
arxiv
Revealing the missing heritability via cross-validated genome-wide association studies [PDF]
arXiv, 2013 Presented here is a simple method for cross-validated genome-wide association studies (cvGWAS). Focusing on phenotype prediction, the method is able to reveal a significant amount of missing heritability by properly selecting a small number of loci with implicit predictive ability.
arxiv
The Cardiovascular Aspects of Marfan's Syndrome: A Heritable Disorder of Connective Tissue [PDF]
, 1955 Victor A. McKusick
openalex +1 more source
Quantitative Measurement of Heritability in the Pre-RNA World [PDF]
arXiv, 2019 Long ago, life obtained nucleotides in the course of evolution and became a vehicle for them. Before assembly with nucleotides, in the pre-RNA era, what system dominated heredity? What was the subject of survival competition? Is it still a subject of competition?
arxiv
Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping [PDF]
arXiv, 2016 The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability estimates of facial traits have often been surprisingly low or difficult to replicate. Furthermore, the construction of facial phenotypes that correspond to naturally perceived facial features remains ...
arxiv
Estimating Broad Sense Heritability via Kernel Ridge Regression [PDF]
arXivThe broad sense genetic heritability, which quantifies the total proportion of phenotypic variation in a population due to genetic factors, is crucial for understanding trait inheritance. While many existing methods focus on estimating narrow sense heritability, which accounts only for additive genetic variation, this paper introduces a kernel ridge ...
arxiv
Rare variant contribution to the heritability of coronary artery disease
Nature CommunicationsWhole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494 controls of ...
Ghislain Rocheleau +56 more
doaj +1 more source
Accurate Genomic Prediction Of Human Height [PDF]
arXiv, 2017 We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, $\sim$40, 20, and 9 percent of total variance for the ...
arxiv