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Effectiveness and cost-effectiveness of unsupervised buprenorphine-naloxone for the treatment of heroin dependence in a randomized waitlist controlled trial

open access: hybrid, 2017
Adrian Dunlop   +13 more
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Naloxone in heroin dependence

Clinical Pharmacology & Therapeutics, 1968
Naloxone is a potent and rapidly acting narcotic antagonist, with a duration of action which is shorter (3 to 4 hours) than that of heroin. In a clinical trial of naloxone in the treatment of heroin dependence, a daily oral dose of 100 mg. at 8 A.M. and 7 P.M. effectively blockaded 20 mg.
Arnoldo Mora   +6 more
openaire   +3 more sources

Acute effects of heroin on emotions in heroin‐dependent patients

The American Journal on Addictions, 2013
BackgroundEuphoria has been described in heroin‐dependent individuals after heroin administration. However, affective disturbances and disorders are common in heroin dependence. The present study examined the acute effects of heroin on emotions in heroin‐dependent patients.MethodsThis randomized controlled crossover trial included 28 heroin‐dependent ...
Blum, J.   +8 more
openaire   +4 more sources

Buprenorphine and Naloxone for Heroin Dependence

Current Psychiatry Reports, 2000
The pharmacology of buprenorphine is unique because of its partial agonist profile at the mu-opioid receptor (ie, high affinity, low intrinsic activity and slow dissociation). This unique profile results in greater safety, less physical dependence, and greater flexibility in dose scheduling.
Jeffrey C. McCagh, Rolley E. Johnson
openaire   +3 more sources

Heroin maintenance for chronic heroin dependents

2003
Dependent heroin users are characterised by the persistence of use in spite of the difficulties they experience with health, law, social achievements and personal relationships. The present review will consider maintenance treatment in which the patients enter programs of pharmacological administration tailored to achieve patient stabilisation.
Carlo A. Perucci   +2 more
openaire   +5 more sources

AVERSION THERAPY FOR HEROIN DEPENDENCE

The Lancet, 1968
Abstract Suxamethonium chloride (' Scoline ') has been used to produce aversion to the process of preparing for self-injection of heroin. The instruction for self-injection is timed to coincide with the onset of paralysis induced by 30 mg. scoline, and the process is repeated for 5 consecutive days.
I.G. Thomson, N.H. Rathod
openaire   +3 more sources

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