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Clinical Pharmacology & Therapeutics, 1968
Naloxone is a potent and rapidly acting narcotic antagonist, with a duration of action which is shorter (3 to 4 hours) than that of heroin. In a clinical trial of naloxone in the treatment of heroin dependence, a daily oral dose of 100 mg. at 8 A.M. and 7 P.M. effectively blockaded 20 mg.
Arnoldo Mora+6 more
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Naloxone is a potent and rapidly acting narcotic antagonist, with a duration of action which is shorter (3 to 4 hours) than that of heroin. In a clinical trial of naloxone in the treatment of heroin dependence, a daily oral dose of 100 mg. at 8 A.M. and 7 P.M. effectively blockaded 20 mg.
Arnoldo Mora+6 more
openaire +3 more sources
Acute effects of heroin on emotions in heroin‐dependent patients
The American Journal on Addictions, 2013BackgroundEuphoria has been described in heroin‐dependent individuals after heroin administration. However, affective disturbances and disorders are common in heroin dependence. The present study examined the acute effects of heroin on emotions in heroin‐dependent patients.MethodsThis randomized controlled crossover trial included 28 heroin‐dependent ...
Blum, J.+8 more
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Buprenorphine and Naloxone for Heroin Dependence
Current Psychiatry Reports, 2000The pharmacology of buprenorphine is unique because of its partial agonist profile at the mu-opioid receptor (ie, high affinity, low intrinsic activity and slow dissociation). This unique profile results in greater safety, less physical dependence, and greater flexibility in dose scheduling.
Jeffrey C. McCagh, Rolley E. Johnson
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Heroin maintenance for chronic heroin dependents
2003Dependent heroin users are characterised by the persistence of use in spite of the difficulties they experience with health, law, social achievements and personal relationships. The present review will consider maintenance treatment in which the patients enter programs of pharmacological administration tailored to achieve patient stabilisation.
Carlo A. Perucci+2 more
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AVERSION THERAPY FOR HEROIN DEPENDENCE
The Lancet, 1968Abstract Suxamethonium chloride (' Scoline ') has been used to produce aversion to the process of preparing for self-injection of heroin. The instruction for self-injection is timed to coincide with the onset of paralysis induced by 30 mg. scoline, and the process is repeated for 5 consecutive days.
I.G. Thomson, N.H. Rathod
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