Results 81 to 90 of about 317,227 (394)

NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA

open access: yesAdvanced Science, EarlyView.
Zhan et al. demonstrate the vital role of NAT10‐catalyzed ac4C modification in regulating autophagy‐associated lysosomal acidification. They uncover the clinical and biological significance of ATP6V0E1, an important v‐ATPase assembly subunit, in tumor metastasis, particularly in the malignant progression of ESCC.
Yu‐Juan Zhan   +23 more
wiley   +1 more source

Detection of infection by Toxoplasma and Herpes simplex virus 2 among women exposed to abortion in Ninavah province/ Iraq

open access: yesTikrit Journal of Pure Science, 2020
The aims of this study were to find the relationship among the infection of Toxoplasma, herpes simplex virus and abortion at different age groups. For this purpose 127 samples from healthy women were collected in period from February to September 2017 ...
Mahmood Nafi Mahmood   +1 more
doaj   +1 more source

Severe diabetic ketoacidosis triggered by concomitant central nervous system and genital Herpes Simplex Virus type 2 infection.

open access: yesMedicina Universitaria, 2022
Diabetic ketoacidosis is a life-threatening acute complication of type-1 diabetes mellitus. It is most frequently precipitated by bacterial infections, although viral pathogens should always be considered.
Victoria A. Ahuett-Lopez   +3 more
doaj   +1 more source

Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]

open access: yes, 2018
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina   +2 more
core   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang   +9 more
wiley   +1 more source

Recombination with Herpes Simplex Virus [PDF]

open access: yesJournal of General Microbiology, 1955
Summary: The behaviour of six strains of herpes simplex virus was studied. Marked differences were noted in the type of lesion formed and the rate of attachment when the strains were inoculated on to the chorio-allantois, and in the behaviour of strains inoculated intracerebrally into mice or on to the cornea of the rabbit.
openaire   +3 more sources

Herpes simplex virus-type1 (HSV-1) impairs DNA repair in cortical neurons [PDF]

open access: yes, 2016
Several findings suggest that Herpes simplex virus-1 (HSV-1) infection plays a role in the neurodegenerative processes that characterize Alzheimer's disease (AD), but the underlying mechanisms have yet to be fully elucidated.
Alessio Cardinale   +12 more
core   +2 more sources

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

open access: yesAdvanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen   +8 more
wiley   +1 more source

Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3

open access: yesInternational Journal of Nanomedicine, 2013
The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases.
Swapnil Gaikwad   +8 more
semanticscholar   +1 more source

An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]

open access: yes, 2011
Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Arthur, J.   +6 more
core   +1 more source

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