Results 1 to 10 of about 5,266 (113)

Antiviral potential of combinations of etiotropic antiherpetic agents including LAS-131, a novel terminase complex inhibitor, to affect the reproduction of herpes simplex virus type 1 (<i>Orthoherpesviridae: Simplexvirus: Simplexvirus humanalpha1</i>)

Voprosy Virusologii
Introduction. Herpes simplex virus type 1 (HSV-1) causes various diseases in humans that can lead to disability and death. Current treatments are effective and relatively safe. However, the high prevalence of HSV, the necessity for long-term therapy associated with the development of drug resistance in the virus (mainly in immunocompromised patients ...
Galina L Levit, V N Charushin, VÍCTOR P Krasnov   +2 more
exaly   +4 more sources

Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection [PDF]

Virus Evolution, 2020
Abstract Whereas the majority of herpesviruses co-speciated with their mammalian hosts, human herpes simplex virus 2 (HSV-2, genus Simplexvirus) most likely originated from the cross-species transmission of chimpanzee herpesvirus 1 to an ancestor of modern humans. We exploited the peculiar evolutionary history of HSV-2 to investigate the
Alessandra Mozzi, Diego Forni, Rachele Cagliani   +2 more
exaly   +4 more sources

Evolution-guided prioritization identifies a tissue-specific phosphorylation switch on herpes simplex virus 1 UL7 regulating viral replication and pathogenicity. [PDF]

J Virol
Although numerous phosphorylation sites on herpes simplex virus 1 (HSV-1) proteins have been identified through phosphoproteomic analyses, their virological significance remains largely unclear.
Kato A, Tannaka T, Iwasaki R, Shio S, Liu S, Takeshima K, Maruzuru Y, Kawaguchi Y.   +7 more
europepmc   +2 more sources

Genus Simplexvirus: Life cycle

Acta Microbiologica Bulgarica, 2023
The two same-name members of the subfamily Alphaherpesvirinae, the human herpesviruses Herpes simplex virus-1 (HSV-1) and Herpes simplex virus-2 (HSV-2), use human epithelial cells to establish their lytic phase, and neuronal cells to establish a lysogenic (latent) phase.
N. Hristova, A.S. Galabov
exaly   +2 more sources

Antiviral Efficacy of Coridothymus capitatus Essential Oil Against HSV-1 and HSV-2. [PDF]

Life (Basel)
Coridothymus capitatus is a perennial herb with aromatic leaves and flowers, distinct from Thymus vulgaris in its chemical composition, resulting in a unique Thymus Essential Oil (TEO).
Fuochi V, Furneri PM, Furnari S, Garozzo A.   +3 more
europepmc   +2 more sources

RETRACTED: High-throughput sequencing in diagnostics and prevention of herpes simplex virus infection (Herpesviridae, Alphaherpesvirinae, Simplexvirus, Human alphaherpesvirus 1)

Problems of Virology, 2020
RETRACTEDHerpes simplex viruses types 1 (HSV-1) and 2 (HSV-2) are among the most common viruses in the human population. The clinical manifestations of HSV infection vary widely, which necessitates reliable molecular methods for the timely diagnosis of herpes virus infection, as well as for detection of mutations in the genes responsible for drug ...
O. V. Sergeyev, R. E. Bosh’ian, I. F. Barinsky   +2 more
openaire   +5 more sources

Pathogenesis, Diseases, Immune Response, and Chemotherapy of Genus Simplexvirus

Acta Microbiologica Bulgarica, 2023
Throughout evolution, members of the genus Simplexvirus have evolved a highly effective pathoge¬netic strategy based on biomolecular interactions with pathogen-sensitive biological species. This in turn leads to pathogen-associated recurrent diseases with a wide range of clinical manifestations, including her¬petic encephalitis (HSE), herpetic ...
N. Hristova, A.S. Galabov
exaly   +2 more sources

CRISPR/Cas9 Reduces Viral Load in a BALB/c Mouse Model of Ocular Herpes Infection. [PDF]

Biomedicines
Background/Objectives: Simplexvirus humanalpha1 (HSV-1) can cause herpetic keratitis, which is the most common cause of infectious blindness in developed countries.
Garcia LS, de Sousa RMP, Campos VS, Ferreira EM, Cascabulho CM, de Souza EM, de Paula VS.   +6 more
europepmc   +2 more sources

Antiviral effect of novel purine conjugate LAS-131 against Herpes simplex virus type 1 (Herpesviridae: Alphaherpesvirinae: Simplexvirus: Human alphaherpesvirus 1) in vitro

Problems of Virology, 2021
Introduction. Herpes simplex viruses type 1 (HSV-1) are extremely widespread throughout the world and, similar to other herpesviruses, establish lifelong persistent infection in the host. Reactivating sporadically, HSV-1 elicits recurrences in both immunocompetent and immunocompromised individuals and can cause serious diseases (blindness, encephalitis,
Andronova, V. L., Galegov, G. A., Musiyak, V. V., Vozdvizhenskaya, O. A., Levit, G. L., Krasnov, V. P.   +5 more
openaire   +6 more sources

Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract

Biotechnology and Biotechnological Equipment, 2023
Astragalus glycyphyllos L. is widely used in Bulgarian folk medicine. Extracts from this plant have antiproliferative, antitumor and immune stimulating effects in vitro and in vivo. The aim of this study was to examine the potential antiviral activity of
Aleksandar Shkondrov, Anton Hinkov, Kalina Shishkova   +2 more
exaly   +3 more sources