Results 31 to 40 of about 5,266 (113)

Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication

Critical Care, 2020
Background Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly defined.
Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M. Berghaus, Michael Wittmann, Georg Braun, Dirk H. Busch, Reinhard Hoffmann   +8 more
doaj   +1 more source

Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders

Cancer Medicine, Volume 8, Issue 3, Page 1013-1023, March 2019., 2019
We sequenced viral DNA from paraffin‐embedded tissues of PTLD and associated to clinical severity and outcomes. Certain EBV genes had higher proportions of nonsynonymous variants. Anellovirus tissue positivity associated with earlier patient death. Abstract Posttransplant lymphoproliferative disorders (PTLDs), 50%‐80% of which are strongly associated ...
Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie   +8 more
wiley   +1 more source

Volatile Acid‐Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long‐Term Treatment of Herpes Simplex Virus‐1 Infections

Journal of Drug Delivery, Volume 2018, Issue 1, 2018., 2018
Treatment for herpes simplex virus‐1 and ‐2 (HSV‐1 and ‐2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir.
James R. Stegman, Jill K. Badin, Kaitlyn A. Biles, Thamar Etienne, Sogand Fartash-Naini, Ariel D. Gordon, Zachary W. Greeley, Benjamin W. Harding, Ricardo J. Mack, Danielle Masica, Ashley N. Nelson, Amandeep K. Samra, Sarah E. Smith, Gabrielle P. Thomas, Haley J. Zack, Timothy J. Brunker, Barry J. Margulies, Carla Caramella   +17 more
wiley   +1 more source

HIV‐1 Replication in HIV‐Infected Individuals Is Significantly Reduced When Peripheral Blood Mononuclear Cells Are Superinfected with HSV‐1

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
Herpes simplex virus (HSV) can cause generalized infection in human immunodeficiency virus‐ (HIV‐) infected patients leading to death. This study investigated HSV‐1 replication in PBMCs from 25 HIV‐infected individuals and 15 healthy donors and the effects of HSV‐1 superinfection on HIV‐1 production.
Taneth Yamsuwan, Chintana Chirathaworn, Pokrath Hansasuta, Parvapan Bhattarakosol, K. Ikuta, N. Maneekarn, A. Zakhartchouk   +6 more
wiley   +1 more source

Viral Infection in Renal Transplant Recipients

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
Viruses are among the most common causes of opportunistic infection after transplantation. The risk for viral infection is a function of the specific virus encountered, the intensity of immune suppression used to prevent graft rejection, and other host factors governing susceptibility.
Jovana Cukuranovic, Sladjana Ugrenovic, Ivan Jovanovic, Milan Visnjic, Vladisav Stefanovic, Stephane Basmaciogullari, Balazs Harrach, Karen Mansfield   +7 more
wiley   +1 more source

Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles

Evidence-Based Complementary and Alternative Medicine, Volume 2011, Issue 1, 2011., 2011
Phyllanthus urinaria Linnea (Euphorbiaceae) is one of the traditional medicinal plants widely used by oriental people to treat various diseases. We have previously demonstrated that the acetone extract of P. urinaria inhibits herpes simplex virus type 2 (HSV‐2) but not HSV‐1 infection.
Hua-Yew Cheng, Chien-Min Yang, Ta-Chen Lin, Liang-Tzung Lin, Lien-Chai Chiang, Chun-Ching Lin   +5 more
wiley   +1 more source

The role of the neuronal microenvironment in sensory function and pain pathophysiology

Journal of Neurochemistry, Volume 168, Issue 11, Page 3620-3643, November 2024.
In this review, we highlight the complex dynamic interactions between sensory neurons and non‐neuronal cells, including immune cells, neuronal accessory cells, adipocytes, and keratinocytes with a focus on skin, neuronal axons, dorsal root ganglia, and spinal cord.
Hana Starobova, Ammar Alshammari, Ingrid G. Winkler, Irina Vetter   +3 more
wiley   +1 more source

Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses

Ecology and Evolution, Volume 14, Issue 6, June 2024.
We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Anna R. Sjodin, Michael R. Willig, Armando Rodríguez‐Durán, Simon J. Anthony   +3 more
wiley   +1 more source

Integration of Planova filters in manufacturing processes of biologicals improve the virus safety effectively: A review of publicly available data

Biotechnology Progress, Volume 40, Issue 1, January/February 2024.
Abstract The capacity to remove viruses by Planova filters produced by Asahi Kasei, primarily by small virus‐retentive filters, were compiled from data in peer‐reviewed publications and, partly, publicly available data from presentations at conferences (Planova workshops).
Albrecht Gröner
wiley   +1 more source

Novel Alpha‐, Beta‐, and Gammaherpesviruses in Neotropical Carnivores of Brazil

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
The knowledge regarding infectious agents affecting wildlife is crucial for species’ conservation. We hypothesized that herpesviruses are present in wild Neotropical carnivores. Herein, we used DNA polymerase and glycoprotein B broad‐spectrum PCRs to molecularly survey the presence of herpesviruses in spleen and/or lung samples of 53 wild Neotropical ...
Ana Carolina Ewbank, José Luiz Catão-Dias, Pedro Enrique Navas-Suarez, Aricia Duarte-Benvenuto, Roberta Zamana-Ramblas, Eduardo Ferreira-Machado, Henrique Christino Lial, Pablo Ibáñez-Porras, Irene Sacristán, Carlos Sacristán, Horacio Bach   +10 more
wiley   +1 more source