Results 21 to 30 of about 8,273 (160)

A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan [PDF]

Human Genomics
Background Periodic bioinformatics-based screening of wastewater for assessing the diversity of potential human viral pathogens circulating in a given community may help to identify novel or potentially emerging infectious diseases.
Yabing Li, Brijen Miyani, Russell A. Faust, Randy E. David, Irene Xagoraraki   +4 more
doaj   +2 more sources

Development of rhesus macaque astrocyte cell lines supporting infection with a panel of viruses. [PDF]

PLoS ONE
Non-human primate (NHP)-based model systems are highly relevant for biomedical research. However, only few NHP cell lines are available and the generation of additional cell lines is an urgent need to help in the refinement and replacement of these ...
Stefanie Reiter, Ting Sun, Sabine Gärtner, Stefan Pöhlmann, Michael Winkler   +4 more
doaj   +2 more sources

Bioinformatics-based screening tool identifies a wide variety of human and zoonotic viruses in Trujillo-Peru wastewater [PDF]

One Health
Peru was one of the most affected countries during the COVID-19 pandemic. Moreover, multiple other viral diseases (enteric, respiratory, bloodborne, and vector-borne) are endemic and rising.
Brijen Miyani, Yabing Li, Heidy Peidro Guzman, Ruben Kenny Briceno, Sabrina Vieyra, Rene Hinojosa, Irene Xagoraraki   +6 more
doaj   +2 more sources

Exploring the Antiviral Potential of Tungsten Oxide Nanoparticles Against Herpes Simplex Virus Type 1: A Promising Alternative to Acyclovir. [PDF]

IET Nanobiotechnol
Herpes simplex virus type 1 (HSV‐1) is responsible for the majority of cold sores, herpetic keratitis‐induced blindness, profound skin lesions, and encephalitis that can be fatal. Currently, acyclovir and its derivatives are the first‐line therapy for the treatment of HSV‐1 infection.
Jwaziri AK, Khales P, Kiani SJ, Yaghouti H, Babaei R, Salavatiha Z, Tavakoli A.   +6 more
europepmc   +2 more sources

A review of latency in the Alloherpesviridae family. [PDF]

J Fish Dis
Abstract The ability to impact the immune response of the host has been recognized as essential for the success of a virus during infection. A few groups of viruses can combine these immunomodulatory mechanisms with specific patterns of their own transcriptional and replication regulation to achieve persistence within the host long term.
Quijano Cardé EM, Soto E.
europepmc   +2 more sources

Astragalus glycyphyllos L.: antiviral activity and tablet dosage formulation of a standardized dry extract

Biotechnology & Biotechnological Equipment, 2023
Astragalus glycyphyllos L. is widely used in Bulgarian folk medicine. Extracts from this plant have antiproliferative, antitumor and immune stimulating effects in vitro and in vivo. The aim of this study was to examine the potential antiviral activity of
Aleksandar Shkondrov, Anton Hinkov, Venelin Cvetkov, Kalina Shishkova, Daniel Todorov, Stoyan Shishkov, Ivan Stambolov, Krassimira Yoncheva, Ilina Krasteva   +8 more
doaj   +1 more source

Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa [PDF]

Nature Communications, 2022
AbstractHuman herpes simplex virus 2 (HSV-2) is a ubiquitous, slowly evolving DNA virus. HSV-2 has two primary lineages, one found in West and Central Africa and the other found worldwide. Competing hypotheses have been proposed to explain how HSV-2 migrated out-of-Africa (i)HSV-2 followed human migration out-of-Africa 50-100 thousand years ago, or (ii)
Havens, Jennifer, Calvignac-Spencer, Sébastien, Merkel, Kevin, Burrel, Sonia, Boutolleau, David, Wertheim, Joel   +5 more
openaire   +6 more sources

Association between human genetic variants affecting the host NK cell response and the development of herpes simplex virus type 1 encephalitis

Journal of Medical Virology, Volume 95, Issue 5, May 2023., 2023
Abstract Herpes simplex virus encephalitis (HSE) is a rare complication of herpes simplex virus type 1 (HSV‐1) infection or reactivation. It is so far unclear why only few patients develop HSE. As natural killer (NK) cells provide an important defense against HSV‐1, we investigated whether there is an association between distinct human genetic variants
Marianne Graninger, Hannes Vietzen, Elisabeth Puchhammer‐Stöckl   +2 more
wiley   +1 more source

The impact of cerebrospinal fluid viral polymerase chain reaction testing on the management of adults with viral meningitis: A multi‐center retrospective study

Journal of Medical Virology, Volume 95, Issue 1, January 2023., 2023
Abstract The aim of this study was to evaluate the role of viral polymerase chain reaction (PCR) testing in patients with aseptic meningitis and identify opportunities for improvement in clinical management. All cerebrospinal fluid samples collected in 1 year from four teaching hospitals in Sydney, Australia, were reviewed.
Myong Gyu Kim, Trine Gulholm, Kate Lennard, Feras Mirdad, Kristen Overton, Michael Maley, Pamela Konecny, David Andresen, Jeffrey John Post, for the Sydney Partnerships for Health, Education, Research and Enterprise (SPHERE) Hospitals Infection Study Group   +11 more
wiley   +1 more source

Rapid and direct detection of herpes simplex virus type 1 and type 2 by Real-Time PCR method in clinical specimens [PDF]

Medical Laboratory Journal, 2023
Background: Herpes simplex viruses (HSV-1 and HSV-2) are a common cause of dermal, oral, and genital infections worldwide. Rapid diagnosis of infected patients will prevent transmission to uninfected individuals. Therefore, this study aimed to detect HSV-
Masoomeh Rezanezhadi, Fahimeh Azadi, Shayan Marhamati, Hamid Reza Joshaghani   +3 more
doaj