Results 141 to 150 of about 108,460,457 (303)

Protective role of Galectin‐3 in prion disease through regulation of microglial PrPSc uptake

Brain Pathology, EarlyView.
Galectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Natallia Makarava, Tarek Safadi, Narayan P. Pandit, Olga Mychko, Olga Bocharova, Alexey Shevelkin, Kara Molesworth, Marta M. Lipinski, Ilia V. Baskakov   +8 more
wiley   +1 more source

Investigating the Relative Frequency of Infection with Herpes Simplex Virus Types 1 and 2 in the Serum of Patients with Multiple Sclerosis via Using Loop-mediated Isothermal Amplification (LAMP)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2014
Introduction: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). It is an Auto immune disease whose cause is still unknown though some factors can be named as its cause such as genetics, geographic element and viral ...
A Atefi, MH Shahhosseiny, K Bidoki, R Mansouri, F Binesh, A Atefi, M Vassei   +6 more
doaj  

Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trial.

, 2010
BACKGROUND: Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (HIV-1) RNA over periods up to 3 months, but the long-term effect is unknown.
Mugeye, Kokugonza, Changalucha, John, Weiss, Helen A, Watson-Jones, Deborah, Tanton, Clare, Hayes, Richard J, Baisley, Kathy, Clayton, Tim C, Rusizoka, Mary, Ross, David A, Everett, Dean, Legoff, Jerome, Belec, Laurent   +12 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Herpes Simplex Virus 1, Macrophages, and the Cornea [PDF]

Journal of Virology, 2017
openaire   +2 more sources

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Identification and expression of a murine cytomegalovirus early gene coding for an Fc receptor [PDF]

, 1994
Several herpesviruses, including cytomegalovirus, induce receptors for the Fc domain of murine immunoglobulin G (IgG) molecules. Viral genes coding for these receptors have been characterized only for alphaherpesviruses. In this report, we describe a new
Eggers, Maren, Thäle, Regine, Koszinowski, Ulrich H., Lucin, Pero, Schneider, Karin   +4 more
core  

A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult‐Onset Primary Lateral Sclerosis‐Like Syndrome

Clinical Genetics, EarlyView.
A 43‐year‐old woman developed a progressive adult‐onset upper motor neuron syndrome fulfilling the clinical criteria for primary lateral sclerosis (PLS), with mild cerebellar involvement. Genetic testing identified a de novo ATP1A3 p.Arg995His variant affecting a highly conserved residue within the transmembrane M8 domain.
Pablo Hernandez‐Vitorique, Marta García de Burgos, Ana Campos Villegas, María José Gómez Heredia, Pilar Carbonell Corvillo   +4 more
wiley   +1 more source

Unmasking Iododerma: A Distinctive Histopathologic Pattern of Neutrophil‐Rich Dermatosis With Haloed Cryptococcoid Bodies in the Setting of Hydralazine Exposure and Autoimmune Serologic Abnormalities

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous iododerma is a rare adverse reaction to iodine‐containing compounds that may clinically and histopathologically mimic infection, vasculitis, malignancy, and other neutrophilic dermatoses. Although most commonly associated with iodinated contrast exposure, a variety of predisposing factors and potential associations have been reported,
Volha Lenskaya, Ana M. Ciurea, Mika Tabata, Teny M. John, Woo Cheal Cho   +4 more
wiley   +1 more source

Herpes Simplex Virus Keratitis – Diagnostic and Therapeutic Challenges

Herpes simplex virus keratitis is one of the leading causes of blindness worldwide. The observed inflammatory changes may result from a primary ocular infection or, more commonly, from recurrent reactivation of the virus, which remains latent in the ...
Ewelina Serkies-Minuth, Paulina Glasner, Katarzyna Michalska-Małecka   +2 more
core   +1 more source