Results 151 to 160 of about 785,480 (280)
The ethanolic root extract of Desmostachya bipinnata exhibited significant anti‐inflammatory and antinociceptive activities in in vitro, in vivo and in silico models, revealing bioactive compounds capable of modulating key inflammatory targets and supporting the plant's traditional therapeutic potential.
Muhammad Hussnain Siddique +6 more
wiley +1 more source
Objective. The aim of this study was to determine the presence of Bovine herpesvirus – 1 (BoHV- 1) and Bovine herpesvirus 5 (BoHV-5) neutralizing antibodies in herds on the Colombian high plains and their correlation with the level of cross-protection ...
Góngora O, Agustín +4 more
core +1 more source
R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar +7 more
wiley +1 more source
The functions of herpesvirus shuttling proteins in the virus lifecycle
During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually ...
Huijun Cao +85 more
doaj +1 more source
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto +14 more
wiley +1 more source
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun +19 more
wiley +1 more source
ABSTRACT Unmapped sequencing reads in livestock often contain valuable information about pathogens but are typically discarded. We analyzed blood‐derived DNA and RNA from chickens and pigs kept under high‐ and low‐biosecurity conditions, focusing on unmapped reads.
Martijn F. L. Derks +3 more
wiley +1 more source
Uusi herpesvirusten sukuun kuuluva virus aiheutti 50 % kuolleisuuteen johtaneen epidemian 1984 hollantilaisessa merinisäkäskeskuksessa. Tämän jälkeen hylkeiden herpesvirusvasta-aineita on todettu useilta Pinnipedia-heimon lajeilta ympäri maailmaa ...
Airikkala, Ilona
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