Results 71 to 80 of about 1,398 (194)
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Equid herpesvirus type 1 generates factor Xa (FXa) in a dose-dependent manner.
Factor Xa generation (nM) was measured with purified virus at different plaque forming units/cell (PFU/cell) using a one stage amidolytic assay with exogenous human FVIIa (1 nM) and FX (75 nM) and a chromogenic FXa substrate (n = 4).
Nicole DeAngelis (654698) +6 more
core +1 more source
Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras +6 more
wiley +1 more source
Latent equine herpesvirus infections in horses
A significant characteristic of the herpesviruses is that they form latent infections in infected hosts, and can be reactivated to again induce lytic infections by stressors.
Hamzah, Hazilawati
core
Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice [PDF]
Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase
Barbeito, Claudio Gustavo +8 more
core +1 more source
Equid alphaherpesvirus 1 (EHV-1) has been linked to the emergence of neurological disorders, with the horse racing industry experiencing significant impacts from outbreaks of equine herpesvirus myeloencephalopathy (EHM).
Yue Hu +7 more
doaj +1 more source
Background Equid alphaherpesvirus 1 (EHV-1) is one of the main infectious causative agents of abortion in mares and can also be associated with stillbirth, neonatal foal death, rhinopneumonitis in young horses and a neurological disorder called equine ...
Anna Karolina Matczuk +3 more
doaj +1 more source
Summary Borna disease is an acute to subacute, rarely chronic non‐purulent meningoencephaylomyelitis affecting mainly horses and sheep. This case series describes the clinical signs, diagnosis, treatment, outcome and post‐mortem findings of five horses and two donkeys with this condition. The equids affected were geldings or mares of various breeds and
I. L. Piotrowski, M. Hilbe, H. K. Junge
wiley +1 more source
Herpesvirus-Associated Neurological Disease in a Donkey
A 4-year-old donkey was evaluated for progressive neurological abnormalities consisting of depression, stupor, weakness, and recumbency. Diagnostic evaluation for viral involvement identified an asinine herpesvirus in DNA extracted from deep pharyngeal ...
Xin Wen +2 more
core +1 more source
Equid herpes virus type-1 (EHV-1) is a major pathogen of horses, causing abortion storms and outbreaks of herpes virus myeloencephalopathy. These clinical syndromes are partly attributed to ischemic injury from thrombosis in placental and spinal vessels.
Tracy Stokol +3 more
doaj +1 more source

