Results 91 to 100 of about 615,507 (219)

Active herpesviruses are associated with intensive care unit (ICU) admission in patients pulmonary infection and alter the respiratory microbiome

Frontiers in Microbiology
BackgroundThe Herpesviridae family contains several human-related viruses, which are able to establish colonizing and latency in the human body, posing a significant threat to the prognosis of patients.
Zhiguang Liu, Chun-jian Qi, Yujia Shi, Tianyu Li, Yuan Fang, Qian Zhang, Qian Zhang   +6 more
doaj   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Integrative Assessment of Desmostachya bipinnata (L.) Root Extract: Anti‐Inflammatory and Antinociceptive Effects Supported by Molecular Docking and Network Pharmacology

Flavour and Fragrance Journal, Volume 41, Issue 4, Page 841-858, July 2026.
The ethanolic root extract of Desmostachya bipinnata exhibited significant anti‐inflammatory and antinociceptive activities in in vitro, in vivo and in silico models, revealing bioactive compounds capable of modulating key inflammatory targets and supporting the plant's traditional therapeutic potential.
Muhammad Hussnain Siddique, Muhammad Muzammil Nazir, Saima Muzammil, Iqra Farzeen, Shafaq Latif, Asma Ashraf, Jorddy Neves Cruz   +6 more
wiley   +1 more source

Generation, characterization, and application of caprine herpesvirus 1 secreted glycoprotein D

Microbiology Spectrum
Caprine herpesvirus 1 (CpHV-1), a member of the Herpesvirales order, Herpesviridae family, Alphaherpesvirinae subfamily, and Simplexvirus genus, is classically associated with two distinct clinical syndromes.
Sergio Minesso, Amienwanlen Eugene Odigie, Valentina Franceschi, Simone Taddei, Vittorio Madia, Maria Tempesta, Gaetano Donofrio   +6 more
doaj   +1 more source

R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar, Alexander Lin, Abigail E. Reeves, Meg Critcher, Gil‐Suk Yang, Sean Hui, Daved H. Fremont, Mia L. Huang   +7 more
wiley   +1 more source

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

EMBO Reports
To globally profile circRNAs, we employ RNA-Sequencing paired with chimeric junction analysis for alpha-, beta-, and gamma-herpesvirus infection. We find circRNAs are, as a population, resistant to host shutoff. We validate this observation using ectopic
Sarah E Dremel, Takanobu Tagawa, Vishal N Koparde, Carmen Hernandez-Perez, Jesse H Arbuckle, Thomas M Kristie, Laurie T Krug, Joseph M Ziegelbauer   +7 more
doaj   +1 more source

Use of bidirectional Mendelian randomization to unveil the association between antibody-mediated immune responses to infectious agents and allergic rhinitis

Human Vaccines & Immunotherapeutics
Allergic rhinitis (AR) is increasingly prevalent, yet diagnostic and therapeutic approaches remain inadequate. Recent studies show links between infectious diseases and noninfectious disorders, but the underlying mechanisms are largely unknown.
Wencan Cao, Xiaxuan Chen, Xinrong Li, Yuxian Wang   +3 more
doaj   +1 more source

Reactivation of latent human immunodeficiency virus 1 by human herpesvirus 6 infection.

Acta virologica, 2007
Infection of the ACH-2 line of human leukemic T cells carrying latent Human immunodeficiency virus 1 (HIV-1) with Human herpesvirus 6 (HHV-6) resulted in an increase in reverse transcriptase (RT) activity, a marker of HIV-1 activation, in the culture supernatant. A similar effect was obtained with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).
Y, Isegawa, J, Katahira, K, Yamanishi, N, Sugimoto   +3 more
openaire   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, Volume 178, Issue 3, Page 417-427, July 2026.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source