Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System
Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS).
Saima Ahmed +8 more
doaj +1 more source
Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies [PDF]
Background/Aims A link between oral cavity infections and chemotherapy-induced oral mucositis (CIOM) in patients with hematological malignancies (HMs) undergoing intensive chemotherapy (IC) or hematopoietic stem cell transplantation (HSCT) has been ...
Junshik Hong +10 more
doaj +1 more source
Glass eels and viruses – a lesson learnt from stocking the eastern German Baltic Sea coast
Abstract Concerns about Anguillid herpesvirus 1 (AngHV‐1) in European eels, especially due to stocking measures, is increasingly coming into focus and raises questions regarding disease monitoring and prevention. In the past, stocking of AngHV‐1‐positive eels into waters assumed AngHV‐1‐free has led to a rapid increase of infected eels in the wild. For
Laura Kullmann +3 more
wiley +1 more source
Induction of Human Immunodeficiency Virus 1 Replication by Human Herpesvirus 8
Abstract Background.—Human immunodeficiency virus 1 (HIV-1)–infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma–associated herpesvirus [KSHV]).
M, Mercader +2 more
openaire +2 more sources
Human herpesvirus type 1 and type 2 disrupt mitochondrial dynamics in human keratinocytes [PDF]
Mitochondrial movement and distribution throughout the cytoplasm is crucial for maintaining cell homeostasis. Mitochondria are dynamic organelles but can be functionally disrupted during infection. Here, we show that the ubiquitous human pathogens HHV-1 and HHV-2 induce changes in the mitochondrial morphology and distribution in the early and late ...
Marcin Chodkowski +9 more
openaire +3 more sources
Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins [PDF]
ABSTRACT Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and ...
Susanna L, Lamers +9 more
openaire +2 more sources
Persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1 [PDF]
Infection of a human lymphoblastoid cell line (Jijoye line derived from a Burkitt lymphoma which contains Epstein-Barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus.
L F, Roumillat +2 more
openaire +2 more sources
Analysis of the human herpesvirus-6 immediate-early 1 protein
Herpesvirus immediate-early (IE) gene products play key roles in establishing productive infections, regulating reactivation from latency and evading immune recognition. Analyses of HHV-6 IE gene expression have revealed that the IE1 gene of the HHV-6A and HHV-6B variants exhibits a higher degree of sequence variation than other regions of the genome ...
Richard, Stanton +4 more
openaire +2 more sources
Background: Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Infections develop in the neonate transplacentally, perinatally or postnatally.
Areej A. Hussein +2 more
doaj +6 more sources
Human Herpesvirus 8 Reactivation and Human Immunodeficiency Virus Type 1 gp120
Abstract Context.—Human herpesvirus 8 (HHV-8) is the presumed etiologic agent of Kaposi sarcoma (KS), the most common neoplasm in patients with acquired immunodeficiency syndrome. Current evidence indicates HHV-8 is necessary, but not sufficient, for KS development without the involvement of other cofactors.
Chun, Lu +4 more
openaire +2 more sources

