Results 61 to 70 of about 174,829 (184)

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT A phase 1b/2 study of the all‐oral “kick‐and‐kill” combo nanatinostat + valganciclovir (nana‐val) showed a ~40% overall response rate in patients with relapsed/refractory Epstein‐Barr virus (EBV)‐associated lymphomas. Despite the promising results in these difficult‐to‐treat cancers, there is little known about the effects of nanatinostat on ...
Ibukun A. Akinyemi, Travis M. Zeigler, Griffin H. Willman, Devshree Patel, Ayman El‐Guindy, Michael T. McIntosh, Sumita Bhaduri‐McIntosh   +6 more
wiley   +1 more source

Respiratory Efficacy of a Multivalent Marker Vaccine Against Bovine Viral Diarrhoea Virus Types 1 and 2, Infectious Bovine Rhinotracheitis Virus, Bovine Respiratory Syncytial Virus, and Bovine Parainfluenza-3 Virus in Young Calves

Vaccines
Background/Objectives: A new multivalent vaccine (DIVENCE® PENTA), containing Bovine viral diarrhoea virus (BVDV) types 1 and 2 recombinant proteins, live gE/tk double gene deleted Bovine Herpesvirus type 1 (BoHV-1 or IBR), live attenuated Bovine ...
Carlos Montbrau, Marta Gibert, Marina Solé, Isabel Barril, Mercè Roca, Lucia Acal, Berta Vázquez, Joaquim Mallorqui, Ricard March   +8 more
doaj   +1 more source

Bacterial and viral agents in cattle with and without respiratory signs in dairy herds from São Paulo and Rio Grande do Sul states, Brazil [PDF]

Pesquisa Veterinária Brasileira
: Bovine respiratory disease is a multifactorial syndrome of complex etiology, involving interactions among bacterial and viral agents, and has a significant impact on the cattle industry worldwide.
Natália H. Pedroso, Iasmim F. Dionisio, Nathalia Roberta D. dos Santos, José Valter J. Silva Júnior, Chester P. Batista, Nathália Decaris, Viviani Gomes, Rudi Weiblen, Eduardo F. Flores   +8 more
doaj   +2 more sources

First Demonstration of Bovine Herpesvirus 2 Infection among Cattle by Neutralization Test in Japan

Journal of Veterinary Medical Science, 2005
Seroepidemiological surveys were performed on neutralizing antibody to bovine herpesvirus 2 (BoHV-2) among cattle in Japan. A total of 1,819 sera were collected from cattle in 27 prefectures from 1997 to 1998. Antibodies were detected in only 18 sera collected from 4 prefectures.
IMAI, Kunitoshi, ISHIHARA, Ryoko, NISHIMORI, Tomoko   +2 more
openaire   +3 more sources

Bovine bacterial abortion caused by Escherichia coli infection

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 3‐year‐old, 500 kg Holstein cow aborted at 7 months of gestation. On histological evaluation of the fetal lungs, abundant neutrophils infiltrated the alveolar spaces, bronchi and bronchioles with intralesional Gram‐negative bacteria, immunolabelled with Escherichia coli immunohistochemistry.
Jéssica Nathyelli da Silva, Daniel Felipe Barrantes Murillo, Augusto Cesar dos Santos Stering, Wuglenya Daislla Martins da Silva, Caroline Argenta Pescador   +4 more
wiley   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Integrative Assessment of Desmostachya bipinnata (L.) Root Extract: Anti‐Inflammatory and Antinociceptive Effects Supported by Molecular Docking and Network Pharmacology

Flavour and Fragrance Journal, Volume 41, Issue 4, Page 841-858, July 2026.
The ethanolic root extract of Desmostachya bipinnata exhibited significant anti‐inflammatory and antinociceptive activities in in vitro, in vivo and in silico models, revealing bioactive compounds capable of modulating key inflammatory targets and supporting the plant's traditional therapeutic potential.
Muhammad Hussnain Siddique, Muhammad Muzammil Nazir, Saima Muzammil, Iqra Farzeen, Shafaq Latif, Asma Ashraf, Jorddy Neves Cruz   +6 more
wiley   +1 more source

R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar, Alexander Lin, Abigail E. Reeves, Meg Critcher, Gil‐Suk Yang, Sean Hui, Daved H. Fremont, Mia L. Huang   +7 more
wiley   +1 more source