Results 161 to 170 of about 170,801 (252)

A New Next‐Generation Sequencing Approach in Human Cytomegalovirus for the Identification of Antiviral Resistance Mutations and Genotypic Classification

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT This study introduces a new procedure for antiviral resistance analysis and genetic classification of human cytomegalovirus (HCMV) using next‐generation sequencing (NGS) adapted to existing methodologies, aiming for more targets due to the recent use of new antivirals. It expands the classical investigation of mutations in UL54 and UL97 genes,
Maria Arnedo‐Muñoz, Ignasi Prats‐Méndez, Alejandra Gónzalez‐Sánchez, Maria Carmen Martín, Ariadna Rando‐Segura, Ibai Los Arcos, Patricia Nadal‐Barón, Narcís Saubi, Natalia Mendoza‐Palomar, Marta Bernat‐Sole, Adaia Albasanz‐Puig, Maria Piñana, Cristina Andrés, Susana Melendo‐Pérez, Nieves Larrosa, Andrés Antón, Juliana Esperalba   +16 more
wiley   +1 more source

Novel Cereblon‐Binding Immunomodulators Have Increased Potency Against Gammaherpesvirus‐ Associated Lymphomas In Vitro

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Primary effusion lymphoma (PEL), which is caused by Kaposi sarcoma herpesvirus (KSHV), and Burkitt lymphoma (BL), a subset of which are associated with Epstein‐Barr virus (EBV), are aggressive non‐Hodgkin's lymphomas. Both have relatively poor survival compared to other lymphomas. Cereblon‐binding immunomodulators (CBIs), such as pomalidomide (
Prabha Shrestha, Emma N. Treco, David A. Davis, Robert Yarchoan   +3 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins

Protein Science, Volume 34, Issue 8, August 2025.
Abstract The ester bond crosslink discovered within bacterial adhesin proteins offers a captivating insight into the convergent evolution of enzyme‐like machinery. Crystal structures reveal a putative catalytic triad comprising an acid–base–nucleophile combination and an oxyanion‐like site that suggests a serine protease‐like mechanism drives the ...
Yuliana Yosaatmadja, Vanessa Ung, Xinlu Liu, Yixuan Zhao, Julia K. Wardega, Aria Shetty, Sophie Schoensee, Ivanhoe K. H. Leung, Jeremy R. Keown, David C. Goldstone, Edward N. Baker, Paul G. Young, Davide Mercadante, Christopher J. Squire   +13 more
wiley   +1 more source

Lichen Planus Following COVID‐19 Infection and Vaccination. Matched Case–Control Study

Australasian Journal of Dermatology, Volume 66, Issue 5, Page 289-295, August 2025.
ABSTRACT Background New‐onset lichen planus (LP) development following COVID‐19 infection/vaccination is reported. Since case series cannot be used to study exposure–outcome associations, we designed this matched case–control study to investigate whether COVID‐19‐related events and de novo LP are associated.
Paolo Giacomo Arduino, Alexey Kubanov, Anna Vlasova, Andrey Martynov, Stefano Petti   +4 more
wiley   +1 more source

Cryptococcal meningitis due to Cryptococcus neoformans VNI in a koala (Phascolarctos cinereus) with progressive neurological disease

Australian Veterinary Journal, Volume 103, Issue 8, Page 487-493, August 2025.
Nearly all cases of cryptococcosis in koalas are caused by Cryptococcus gattii species complex. A rare case of meningitis due to Cryptococcus neoformans VNI/AFLP1 (abbreviated VNI) is described in a koala with nasal colonisation by both species complexes.
A Teh, R Crisman, E Dwars, R Malik, LH de Miranda, W Meyer, M Krockenberger   +6 more
wiley   +1 more source

Applying CRISPR Technologies for the Treatment of Human Herpesvirus Infections: A Scoping Review. [PDF]

Pathogens
Hanssens C, Van Cleemput J.
europepmc   +1 more source

T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to CD46 activation

Clinical and Experimental Neuroimmunology, Volume 16, Issue 3, Page 214-226, August 2025.
Abstract Objective To evaluate the responsiveness of T cells from newly diagnosed multiple sclerosis (MS) patients to CD46 co‐stimulation, a membrane co‐factor protein potentially involved in MS pathogenesis. Methods T cells from MS patients and non‐diseased symptomatic controls (SC) were activated in vitro with or without αCD46 antibody co‐stimulation.
Linda Sundvall, Litten S. Rossen, Vivien R. Schack, Bettina Bundgaard, Peter V. Rasmussen, Thor Petersen, Per Höllsberg   +6 more
wiley   +1 more source

Human Herpesvirus 8 in Solid Organ Transplant Donors and Recipients: Need for Screening? A Dutch Seroprevalence Pilot Study. [PDF]

J Med Virol
Roo-Brand G, Zhou X, Van Leer-Buter C, Knoester M.   +3 more
europepmc   +1 more source