Results 21 to 30 of about 613,530 (223)

Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways

Microorganisms, 2021
Herpesviruses are DNA viruses that infect humans and animals with the ability to induce latent and lytic infections in their hosts, causing critical health complications.
Miroslava Šudomová, Sherif T. S. Hassan   +1 more
doaj   +1 more source

Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant [PDF]

Neonatal Medicine, 2019
Herpes simplex virus (HSV) is a common pathogen, that causes a broad spectrum of diseases, ranging from minor skin infections to severe encephalitis and widespread infections.
Mi Hye Bae, Na Rae Lee, Young Mi Han, Lira Yoon, Young Mi Kim, Shin Yun Byun, Jae Jung Lee, Han Jo Kwon, Min Jung Kwak, Kyung Hee Park   +9 more
doaj   +1 more source

Human herpesvirus type 1 and type 2 disrupt mitochondrial dynamics in human keratinocytes [PDF]

Archives of Virology, 2018
Mitochondrial movement and distribution throughout the cytoplasm is crucial for maintaining cell homeostasis. Mitochondria are dynamic organelles but can be functionally disrupted during infection. Here, we show that the ubiquitous human pathogens HHV-1 and HHV-2 induce changes in the mitochondrial morphology and distribution in the early and late ...
Marcin Chodkowski, Izabela Serafińska, Joanna Brzezicka, Anna Golke, Anna Słońska, Małgorzata Krzyżowska, Piotr Orłowski, Piotr Bąska, Marcin W. Bańbura, Joanna Cymerys   +9 more
openaire   +2 more sources

Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System

Viruses, 2022
Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS).
Saima Ahmed, Patrick van Zalm, Emily A. Rudmann, Michael Leone, Kiana Keller, John A. Branda, Judith Steen, Shibani S. Mukerji, Hanno Steen   +8 more
doaj   +1 more source

Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene [PDF]

Journal of Virology, 1997
Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain,
V E, Nava, E H, Cheng, M, Veliuona, S, Zou, R J, Clem, M L, Mayer, J M, Hardwick   +6 more
openaire   +2 more sources

Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins [PDF]

Journal of Virology, 2015
ABSTRACT Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and ...
Susanna L, Lamers, Ruchi M, Newman, Oliver, Laeyendecker, Aaron A R, Tobian, Robert C, Colgrove, Stuart C, Ray, David M, Koelle, Jeffrey, Cohen, David M, Knipe, Thomas C, Quinn   +9 more
openaire   +2 more sources

Review part 2: Human herpesvirus‐6 in central nervous system diseases [PDF]

Journal of Medical Virology, 2010
AbstractJ. Med. Virol. 82:1669–1678, 2010. © 2010 Wiley‐Liss, Inc.
Yao, Karen, Crawford, John, Komaroff, Anthony, Ablashi, Dharam, Jacobson, Steven   +4 more
openaire   +4 more sources

Arginine inactivates human herpesvirus 2 and inhibits genital herpesvirus infection

International Journal of Molecular Medicine, 2012
Arginine, among the amino acids, has demonstrated unique properties, including suppression of protein-protein interactions and virus inactivation. We investigated the effects of arginine on the infectivity of human herpesvirus 2 (HHV-2) and the potential application of arginine as a chemotherapeutic agent against genital herpes.
Keiko, Ikeda, Hisashi, Yamasaki, Sawako, Minami, Yukiko, Suzuki, Kazuko, Tsujimoto, Yoshihisa, Sekino, Hiroshi, Irie, Tsutomu, Arakawa, A Hajime, Koyama   +8 more
openaire   +3 more sources

Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases. [PDF]

PLoS Pathogens, 2010
The UL97 protein of human cytomegalovirus (HCMV, or HHV-5 (human herpesvirus 5)), is a kinase that phosphorylates the cellular retinoblastoma (Rb) tumor suppressor and lamin A/C proteins that are also substrates of cellular cyclin-dependent kinases (Cdks)
Chad V Kuny, Karen Chinchilla, Michael R Culbertson, Robert F Kalejta   +3 more
doaj   +1 more source

Seroprevalencia contra agentes ToRCH en mujeres indígenas en edad fértil, estado Zulia, Venezuela

Biomédica: revista del Instituto Nacional de Salud, 2012
Introducción. El termino ToRCH comprende a los patógenos Toxoplasma gondii, virus de la rubéola, citomegalovirus y virus herpes simple 1 y 2. En mujeres embarazadas expuestas pueden ser causa de abortos y malformaciones congénitas en el neonato ...
Francisca Mercedes Monsalve-Castillo, Luciana Ana Costa-León, María Elena Castellano, Anais Suárez, Ricardo José Atencio   +4 more
doaj   +1 more source