Results 1 to 10 of about 1,291,105 (289)

Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System

Viruses, 2022
Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS).
Saima Ahmed, Patrick van Zalm, Emily A. Rudmann, Michael Leone, Kiana Keller, John A. Branda, Judith Steen, Shibani S. Mukerji, Hanno Steen   +8 more
doaj   +2 more sources

A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3. [PDF]

PLoS ONE, 2015
We report the first de novo sequence assembly and analysis of the genome of Testudinid herpesvirus 3 (TeHV3), one of the most pathogenic chelonian herpesviruses.
Francesco C Origgi, Marco Tecilla, Paola Pilo, Fabio Aloisio, Patricia Otten, Lisandra Aguilar-Bultet, Ursula Sattler, Paola Roccabianca, Carlos H Romero, David C Bloom, Elliott R Jacobson   +10 more
doaj   +2 more sources

Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells [PDF]

International Journal of Molecular Sciences, 2017
Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has been shown to induce cell death in cancer cells. Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpesvirus 8 (HHV8).
Ching‐Yi Tsai, Chang-Yu Chen, Y. Chiou, Huey-Wen Shyu, Kuan-Hua Lin, M. Chou, Mei‐Han Huang, Yi-Fen Wang   +7 more
semanticscholar   +4 more sources

Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase [PDF]

Journal of Virology, 2018
ABSTRACT Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRF-1 to -4) that likely function to suppress innate immune and cellular stress responses through inhibitory interactions with various cellular proteins involved in these activities.
Qiwang Xiang, Hyunwoo Ju, Qian Li, Szu-Chieh Mei, Daming Chen, Y. Choi, J. Nicholas   +6 more
semanticscholar   +4 more sources

Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration [PDF]

Journal of Virology, 2017
ABSTRACT Human herpesvirus 6B (HHV-6B) is a neurotropic betaherpesvirus that achieves latency by integrating its genome into host cell chromosomes. Several viruses can induce epigenetic modifications in their host cells, but no study has investigated the epigenetic modifications induced by HHV-6B.
E. Engdahl, N. Dunn, P. Niehusmann, S. Wideman, P. Wipfler, A. Becker, T. Ekström, Malin A. E. Almgren, A. Fogdell-Hahn   +8 more
semanticscholar   +3 more sources

Cytomegalovirus, Epstein-Barr virus and human herpesvirus 8 salivary shedding in HIV positive men who have sex with men with controlled and uncontrolled plasma HIV viremia: a 24-month longitudinal study

BMC Infectious Diseases, 2018
Background This longitudinal study described Cytomegalovirus (CMV) DNA, Epstein-Barr (EBV) DNA and human herpesvirus 8 (HHV-8) DNA asymptomatic salivary shedding in HIV-positive men who have sex with men (MSM).
Monica Basso, Samantha Andreis, Renzo Scaggiante, Elisa Franchin, Daniela Zago, Maria Angela Biasolo, Claudia Del Vecchio, Carlo Mengoli, Loredana Sarmati, Massimo Andreoni, Giorgio Palù, Saverio Giuseppe Parisi   +11 more
doaj   +2 more sources

Callitrichine gammaherpesvirus 3 and Human alphaherpesvirus 1 in New World Primate negative for yellow fever virus in Rio de Janeiro, Brazil [PDF]

Memorias do Instituto Oswaldo Cruz, 2022
BACKGROUND Herpesvirus transmission between humans and non-human primate (NHP) can occur through contact scratches with lesions, infected saliva, and mainly through contaminated food.
Flávia Freitas de Oliveira Bonfim, Maria Angélica Monteiro de Mello Mares-Guia, Marco Aurélio Horta, Marcia Chame, Amanda de Oliveira Lopes, Rafael Santos, Carlos Alexandre Rey Matias, Marcelo Alves Pinto, Ana Maria Bispo de Filippis, Vanessa Salete de Paula   +9 more
doaj   +1 more source

Immunogenicity of Varicella-Zoster Virus Glycoprotein E Formulated with Lipid Nanoparticles and Nucleic Immunostimulators in Mice

Vaccines, 2021
Theoretically, the subunit herpes zoster vaccine ShingrixTM could be used as a varicella vaccine that avoids the risk of developing shingles from vaccination, but bedside mixing strategies and the limited supply of the adjuvant component QS21 have made ...
Han Cao, Yunfei Wang, Ning Luan, Cunbao Liu   +3 more
doaj   +1 more source

Binding of Transmembrane Mucins to Galectin-3 Limits Herpesvirus 1 Infection of Human Corneal Keratinocytes [PDF]

Journal of Virology, 2013
ABSTRACT Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fundamental cellular
Jerome Mauris, Pablo Argüeso, Ashley M. Woodward   +2 more
openaire   +3 more sources

Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda [PDF]

AIDS, 2018
Kaposi sarcoma is a HIV-associated malignancy caused by human herpesvirus-8 (HHV-8) that occurs at highest incidence in sub-Saharan Africa. Kaposi sarcoma patients often present with inflammatory symptoms associated with higher mortality.We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 supplementation ...
Anna E. Coghill, Jackson Orem, Corey Casper, Corey Casper, Corey Casper, Zeina Mahkoul, Jeannette M. Schenk, Warren Phipps, Warren Phipps   +8 more
openaire   +2 more sources