Results 191 to 200 of about 611,384 (239)

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Journal of Medicinal Chemistry, 2005
A novel series of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV).
Mark E, Schnute, Michele M, Cudahy, Roger J, Brideau, Fred L, Homa, Todd A, Hopkins, Mary L, Knechtel, Nancee L, Oien, Thomas W, Pitts, Roger A, Poorman, Michael W, Wathen, Janet L, Wieber   +10 more
openaire   +2 more sources

Modulation of CD4, CXCR-4, and CCR-5 Makes Human Hematopoietic Progenitor Cell Lines Infected with Human Herpesvirus-6 Susceptible to Human Immunodeficiency Virus Type 1

Journal of Hematotherapy & Stem Cell Research, 2000
Two CD34+ human hematopoietic progenitor cell (HPC) lines, KG-1 and TF-1, became susceptible to human immunodeficiency virus type 1 (HIV-1) infection in the presence of a concurrent infection by human herpesvirus-6 (HHV-6). We have analyzed the possible mechanism(s) underlying this phenomenon in light of the recent demonstration that at least two ...
M, Vignoli, G, Furlini, M C, Re, E, Ramazzotti, M, La Placa   +4 more
openaire   +2 more sources

Detection and Analysis of Protein‐Protein Interactions between KU70 and BHRF1, a BCL2 viral analog within Human gamma herpesvirus 4

The FASEB Journal, 2020
The Epstein‐Barr virus, also known as human gamma herpesvirus 4 (HHV‐4), affects more than 90% of the adult human population worldwide. To prevent premature death of the host cell, HHV‐4 encodes for BHRF1, an anti‐apoptotic protein with sequence and structural similarities to other proteins involved in apoptosis such as BCL2, BAX and BAK, among others.
Sheighlah McManus, Alexander Emami, Alberto Zamora   +2 more
openaire   +1 more source

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Bioorganic & Medicinal Chemistry Letters, 2008
A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Mark E, Schnute, Roger J, Brideau, Sarah A, Collier, Michele M, Cudahy, Todd A, Hopkins, Mary L, Knechtel, Nancee L, Oien, Robert S, Sackett, Allen, Scott, Mari L, Stephan, Michael W, Wathen, Janet L, Wieber   +11 more
openaire   +2 more sources

Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties

Archives of Virology, 2011
Human herpesvirus 8 (HHV-8) triggers proangiogenic behaviour in endothelial cells by inducing monocyte chemoattractant protein 1 (MCP-1) through activation of Nuclear Factor κB (NF-κB). However, NF-κB inhibition still results in partial MCP-1 induction and consequent angiogenesis, suggesting the involvement of another transcriptional pathway.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GRIGOLATO, Jessica, Caruso A., DI LUCA, Dario   +4 more
openaire   +3 more sources

Tim-1 and Tim-4 mediate entry of the human Kaposi’s sarcoma-associated herpesvirus and the related rhesus monkey rhadinovirus

2023
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different receptors, among them heparan sulfate proteoglycans, Eph family receptors, and integrins. We mutated the
Stefano Scribano, Sarah Schlagowski, Shanchuan Liu, Thomas Fricke, Xiaoliang Yang, Frank Neipel, Anna K. Großkopf, Bojan F. Hörnich, Marija Backovic, Armin Ensser, Alexander S. Hahn   +10 more
openaire   +1 more source

DIAGNOSIS OF AN ALLERGIC REACTION TO ANTIBIOTICS IN AN PATIENT WITH ACTIVE HUMAN HERPESVIRUS -4, -6 TYPE INFECTION (CLINICAL CASE).

Georgian medical news, 2022
Beta-lactam antibiotics (BLAs) can provoke drug hypersensitivity reactions, particularly delayed-type reactions. This article presents a case of drug allergy with manifestations of Stevens-Johnson syndrome (SJD) in a 42-year-old man with yersiniosis and active herpesvirus -4, -6 type, who received amoxacillin with clavulanic acid. The patient underwent
S, Zubchenko, A, Havrylyuk, M, Lomikovska, I, Kril, S, Chuiko   +4 more
openaire   +1 more source

Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library

Journal of Virological Methods, 2007
Human herpesvirus 8 (HHV-8) is associated with the development of Kaposi's sarcoma and several other human malignancies. Kaposin A protein of HHV-8 has been demonstrated as inducing tumorigenic transformation, being responsible for nuclear receptor coactivators in the transforming activity.
Cheng-Wen, Lin, Ping-Feng, Tu, Nai-Wan, Hsiao, Ching-Yao, Chang, Lei, Wan, Yu-Tsun, Lin, Hsueh-Wei, Chang   +6 more
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Effect of IL‐12 and soluble IL‐4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate

Immunology & Cell Biology, 2004
Th2 cytokines, commonly detected in burn patients, have been shown as inhibitors for the generation of Th1 cells that are essential for the host's resistance against herpes simplex virus type 1 (HSV‐1) infection. In this study, the possibility of immunological treatment through the regulation of Th1/Th2 responses was examined in two kinds of human ...
Tatsushi, Katakura, Makiko, Kobayashi, David N, Herndon, Fujio, Suzuki   +3 more
openaire   +2 more sources

4: Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A (HHV-6A) in astrocytes and in T-cells

Journal of Clinical Virology, 2006
The ultrastructural replication cycle of human herpesvirus 6A and 6B, both T-lymphotropic viruses, with tropism for the central nervous system,wascomparedbyelectronmicroscopyin the same cells, that is, in the T-lymphoblastoid cell line SupT-1 and in human astrocytes.
J. Ahlqvist, D. Donati, E. Martinelli, N. Akhyani, J. Hou, E.O. Major, S. Jacobson, A. Fogdell-Hahn   +7 more
openaire   +1 more source