Results 71 to 80 of about 79,121,524 (214)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Enfermidades do sistema nervoso dos ruminantes no sul do Rio Grande do Sul Neurological diseases in ruminants in southern Brazil

Ciência Rural, 1998
Descrevem-se os aspectos epidemiológicos, clínicos e patológicos das enfermidades do sistema nervoso central dos ruminantes, diagnosticadas na região Sul do Rio Grande do Sul, incluindo: abiotrofia cerebelar; hipoplasia cerebelar; hipermetria hereditária;
Franklin Riet-Correa, Ana Lucia Schild, Cristina Gevehr Fernandes   +2 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Cloning of Bovine herpesvirus type 1 and type 5 as infectious bacterial artifical chromosomes

BMC Research Notes, 2009
Background Bovine herpesviruses type 1 (BoHV1) and type 5 (BoHV5) are two closely related pathogens of cattle. The identity of the two viruses on the amino acid level averages 82%.
Ackermann Mathias, Fraefel Cornel, Gabev Evgeni, Tobler Kurt   +3 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Identification and Characterization of the Bovine Herpesvirus 5 US4 Gene and Gene Products

Virology, 1996
The BHV-5 strain N569 (BHV-5/N569) homolog to the BHV-1 US4 gene was sequenced and characterized. RNA analyses showed that a 1.8-kb mRNA which contains the BHV-5/N569 US4 open reading frame initiates 55 nucleotides upstream from the predicted translational start codon and terminates 17 nucleotides downstream from the consensus sequence for ...
Engelhardt, Thyl, Keil, Günther M.
openaire   +2 more sources

Bovine Viral Diarrhea Virus Infections in Commingled and Transported Calves: Fall 2000 Study and Summary of a Three-year Study

, 2001
Bovine viral diarrhea virus (BVDV) infections, in both persistently infected (PI) and/or acutely infected calves, were investigated in commingled and transported calves. Other viral infections such as bovine herpesvirus-1 (BHV), parainfluenza-3 virus (Pl-
Confer, A. W., Loan, R. W., Burge, L. J., Duff, G. C., Saliki, J. T., Step, D. L., Fulton, R. W., Purdy, C. W., Briggs, R. E., Ridpath, J. F.   +9 more
core   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, Volume 42, Issue 5, September/October 2026.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Detection of bovine herpesvirus 1 and 5 in semen from Brazilian bulls

Theriogenology, 2011
Bovine herpesvirus 1 (BoHV-1) and 5 (BoHV-5) are important pathogens of the respiratory and genital tract of cattle and may also affect the central nervous system and cause meningoencephalitis. Both virus types are estimated to be widely distributed in Southern Brazil. In the present study, BoHV-1 and/or BoHV-5 DNA were detected in bovine semen samples
Oliveira, M.T., Campos, F.S., Dias, M.M., Velho, F.A., Freneau, G.E., Brito, W.M.E.D., Rijsewijk, F.A.M., Franco, A.C., Roehe, P.M.   +8 more
openaire   +2 more sources

Serum antibody response in calves receiving modified live and/or inactivated vaccines containing bovine herpesvirus-1, bovine viral diarrhea virus, parainfluenza-3 virus, and bovine respiratory syncytial virus immunogens

, 1997
Serum antibody responses to bovine herpesvirus-1 (BHV-1) bovine viral diarrhea virus (BVDV), parainfluenza-3 virus (PI-3V), and bovine respiratory syncytial virus (BRSV) by calves receiving viral vaccines were evaluated.
Burge, Lurinda J., Payton, Mark E., Fulton, Robert W., d\u27Offay, J. M.   +3 more
core   +1 more source