Results 91 to 100 of about 640,708 (297)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Human herpesvirus-6 infection in a critically ill and immunocompetent patient: a case report

Journal of Medical Case Reports
Background Human herpesvirus-6 is a rare infection in an immunocompetent adult. In existing literature, there is a dearth of knowledge that mainly exists as case reports and case series.
Xin Tian Chia, Hai Liang Marc Wong, Jia Shen Loh   +2 more
doaj   +1 more source

Herpes simplex virus 1 rhombencephalitis in a patient with chromosomally integrated human herpesvirus-6A

IDCases, 2020
Central nervous system infection caused by Herpes simplex virus 1 remains a significant cause of morbidity and mortality in transplant patients. Additionally, the clinical implications of the recently discovered Human herpesvirus 6A are still under ...
Raquel Silva, Vitor Duque, Rita Magano, Luís Trindade   +3 more
doaj   +1 more source

Genome sequence of an alphaherpesvirus from a beluga whale (Delphinapterus leucas) [PDF]

, 2017
Beluga whale alphaherpesvirus 1 was isolated from a blowhole swab taken from a juvenile beluga whale. The genome is 144,144 bp in size and contains 86 putative genes. The virus groups phylogenetically with members of the genus Varicellovirus in subfamily
Burek-Huntington, Kathy A., Davison, Andrew J., Jacob, Jessica M., Nielsen, Ole, Romero, Carlos H., Subramaniam, Kuttichantran, Waltzek, Thomas B.   +6 more
core   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, EarlyView.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source

Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents

Infection and Drug Resistance, 2019
Ali A Ghweil, Mohamad M Helal Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt Background: We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C
Ghweil AA, Helal MM
doaj  

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Screening donors for xenotransplantation: The potential for xenozoonoses [PDF]

, 1994
Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following ...
Kahleen, B, Kalter, S, McMichael, JP, Michaels, MG, Peters, RL, Simmons, RL, Starzl, TE   +6 more
core   +1 more source

Postoperative Pain After Endodontic Treatment in HIV‐Positive Patients Under HAART: A Prospective Observational Cohort Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim To compare post‐operative pain following root canal treatment (RCT) in HIV‐positive patients receiving highly active antiretroviral therapy (HAART) and HIV‐negative patients and to assess the influence of systemic condition on endodontic pain.
Marcos Felipe Iparraguirre Nuñovero, Marco Antonio Hungaro Duarte, Luciana Reis Azevedo Alanis, Bruno Cavalini Cavenago, Ulisses Xavier da Silva Neto, Everdan Carneiro   +5 more
wiley   +1 more source

Distinct herpesvirus resistances and immune responses of three gynogenetic clones of gibel carp revealed by comprehensive transcriptomes

BMC Genomics, 2017
Background Gibel carp is an important aquaculture species in China, and a herpesvirus, called as Carassius auratus herpesvirus (CaHV), has hampered the aquaculture development. Diverse gynogenetic clones of gibel carp have been identified or created, and
Fan-Xiang Gao, Yang Wang, Qi-Ya Zhang, Cheng-Yan Mou, Zhi Li, Yuan-Sheng Deng, Li Zhou, Jian-Fang Gui   +7 more
doaj   +1 more source