Results 61 to 70 of about 640,708 (297)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Long Non-Coding RNAs: Novel Players in Regulation of Immune Response Upon Herpesvirus Infection
Frontiers in Immunology, 2018 Herpesviruses have developed a variety of sophisticated immune evasion strategies to establish lifelong latent infection, including the use of long non-coding RNAs (lncRNAs).
Waqas Ahmed +3 more
doaj +1 more source
Post-exposure vaccination improves gammaherpesvirus neutralization.
PLoS ONE, 2007 Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization ...
Laurent Gillet +2 more
doaj +1 more source
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. [PDF]
, 2018 Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms.
Fan Li +9 more
core +3 more sources
JEADV Clinical Practice, EarlyView.ABSTRACT Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus 8 (HHV‐8), typically affecting immunocompromised individuals. However, emerging reports describe cases in HIV‐negative men who have sex with men (MSM), constituting a proposed non‐epidemic variant.
M. Sin‐Soler +5 more
wiley +1 more source
Viruses, 2017 Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness.
Matthew R. Pennington +2 more
doaj +1 more source
IFNα and IFNγ Impede Marek’s Disease Progression [PDF]
, 2019 Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D. +6 more
core +1 more source
Upper Airway Obstruction due to Kaposi Sarcoma—Presenting Sign of HIV: Case Report and Review
The Laryngoscope, EarlyView.This study presents a case of undiagnosed HIV presenting with Kaposi sarcoma (KS) of the head and neck with acute upper airway obstruction (UAO) and provides an updated scoping literature review to examine the patient characteristics, lesion characteristics, interventions, and outcomes of KS cases with UAO from the pharynx, larynx, and/or trachea.
Zachary A. Wykoff +3 more
wiley +1 more source
Italian Journal of Animal Science, 2010 Information on the distribution and related epidemiological characteristics of herpesvirus infections, and in particular referring to Bovine Herpesvirus 1 (BoHV1) and Bubaline Herpesvirus 1 (BuHV1) in buffaloes, have to date not been reported.
G.L. Autorino +7 more
doaj +1 more source
People and Nature, EarlyView.Abstract Understanding the frequency and socio‐ecological drivers of contacts between humans and non‐human primates (NHPs) is crucial for enhancing coexistence that favours NHP conservation, while limiting negative consequences such as aggressions and cross‐species disease transmission.
Cristina Caparrós‐Vallcorba +3 more
wiley +1 more source