Heterochromatin protein 1 (HP1): interactions with itself and chromatin components. [PDF]
Biophys Rev, 2020 Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual ...
Kumar A, Kumar A, Kono H.
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Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. [PDF]
PLoS ONE, 2013 Heterochromatin protein 1 (HP1) is an essential heterochromatin-associated protein typically involved in the epigenetic regulation of gene silencing. However, recent reports have demonstrated that HP1 can also activate gene expression in certain contexts
Patima Sdek +5 more
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Heterochromatin protein 1 (HP1) is intrinsically required for post-transcriptional regulation of Drosophila Germline Stem Cell (GSC) maintenance. [PDF]
Sci Rep, 2019 A very important open question in stem cells regulation is how the fine balance between GSCs self-renewal and differentiation is orchestrated at the molecular level.
Casale AM +3 more
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BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). [PDF]
Oncotarget, 2017 Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC.
Pongas G +9 more
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Expression and chromatin structures of cellulolytic enzyme gene regulated by heterochromatin protein 1. [PDF]
Biotechnol Biofuels, 2016 BackgroundHeterochromatin protein 1 (HP1, homologue HepA in Penicillium oxalicum) binding is associated with a highly compact chromatin state accompanied by gene silencing or repression. HP1 loss leads to the derepression of gene expression.
Zhang X, Qu Y, Qin Y.
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Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells. [PDF]
Sci Rep, 2015 Heterochromatin protein 1 (HP1) is a central factor in establishing and maintaining the heterochromatin state. As consequence of playing a structural role in heterochromatin, HP1 proteins can have both an activating as well as repressive function in gene
Hinde E, Cardarelli F, Gratton E.
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An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions [PDF]
Epigenetics, 2017 The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila +9 more
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Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1. [PDF]
J Biol Chem, 2017 Heterochromatin protein 1 (HP1), a highly conserved non-histone chromosomal protein in eukaryotes, plays important roles in the regulation of gene transcription. Each of the three human homologs of HP1 includes a chromoshadow domain (CSD).
Liu Y +7 more
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Comparison of three heterochromatin protein 1 homologs in Drosophila [PDF]
Journal of Cell Science, 2019 Heterochromatin protein 1 (HP1) is an epigenetic regulator of chromatin structure and genome function in eukaryotes. Despite shared features, most eukaryotes have a minimum of three HP1 homologs with differential localization patterns and functions. Most
Dong Hoon Lee +3 more
semanticscholar +3 more sources
Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1 [PDF]
Nature CommunicationsHP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Amanda Ames +8 more
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