Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition [PDF]
Advanced ScienceAging of the fetal membranes participates in labor onset. However, the underlying mechanism is poorly understood. Here, we identify that the classical secretory protein S100 calcium‐binding protein A9 (S100A9), upon de‐phosphorylation at Thr 113 ...
Fan Zhang +8 more
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Phosphorylation of Heterochromatin Protein 1 by Casein Kinase II Is Required for Efficient Heterochromatin Binding inDrosophila [PDF]
Journal of Biological Chemistry, 1999 Heterochromatin-associated protein 1 (HP1) is a nonhistone chromosomal protein with a dose-dependent effect on heterochromatin mediated position-effect silencing. It is multiply phosphorylated in vivo. Hyperphosphorylation of HP1 is correlated with heterochromatin assembly.
Tao Zhao, Joel C. Eissenberg
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Genetics, 2000 Abstract The Su(var)2-5 locus, an essential gene in Drosophila, encodes the heterochromatin-associated protein HP1. Here, we show that the Su(var)2-5 lethal period is late third instar. Maternal HP1 is still detectable in first instar larvae, but disappears by third instar, suggesting that developmentally late lethality is probably the ...
B. Y. Lu +4 more
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Multiscale Analysis of Dynamics and Interactions of Heterochromatin Protein 1 by Fluorescence Fluctuation Microscopy [PDF]
Biophysical Journal, 2009 Heterochromatin protein 1 (HP1) is a central factor in establishing and maintaining the repressive heterochromatin state. To elucidate its mobility and interactions, we conducted a comprehensive analysis on different time and length scales by fluorescence fluctuation microscopy in mouse cell lines.
Katharina P. Müller +9 more
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Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome [PDF]
Genome Research, 2010 The replication of a chromosomal region during S phase can be highly dynamic between cell types that differ in transcriptome and epigenome. Early replication timing has been positively correlated with several histone modifications that occur at active genes, while repressive histone modifications mark late replicating regions.
Michaela Schwaiger +4 more
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Linking Heterochromatin Protein 1 (HP1) to cancer progression [PDF]
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2008 All cells of a given organism contain nearly identical genetic information, yet tissues display unique gene expression profiles. This specificity is in part due to transcriptional control by epigenetic mechanisms that involve post-translational modifications of histones. These modifications affect the folding of the chromatin fiber and serve as binding
George Dialynas +2 more
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Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1 [PDF]
Nature CommunicationsHP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors.
Amanda Ames +8 more
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Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells. [PDF]
Sci Rep, 2015 AbstractHeterochromatin protein 1 (HP1) is a central factor in establishing and maintaining the heterochromatin state. As consequence of playing a structural role in heterochromatin, HP1 proteins can have both an activating as well as repressive function in gene expression.
Hinde E, Cardarelli F, Gratton E.
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The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1 [PDF]
Archives of Biochemistry and Biophysics, 2012 Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and degrades hypoxia inducible factor-α (HIF-α). Degradation of HIF-α by VHL is proposed to suppress tumorigenesis and tumor angiogenesis.
Yanlai Lai +4 more
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TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells. [PDF]
Oncogene, 2019 Crawford NT +5 more
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