Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. [PDF]
PLoS ONE, 2013 Heterochromatin protein 1 (HP1) is an essential heterochromatin-associated protein typically involved in the epigenetic regulation of gene silencing. However, recent reports have demonstrated that HP1 can also activate gene expression in certain contexts
Patima Sdek +5 more
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Heterochromatin Protein 1: A Multiplayer in Cancer Progression. [PDF]
Cancers (Basel), 2022 Dysregulation of epigenetic mechanisms as well as genomic mutations contribute to the initiation and progression of cancer. In addition to histone code writers, including histone lysine methyltransferase (KMT), and histone code erasers, including histone lysine demethylase (KDM), histone code reader proteins such as HP1 are associated with abnormal ...
Jeon YH +7 more
europepmc +4 more sources
Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro [PDF]
Journal of Biological Chemistry, 2000 Heterochromatin protein 1 (HP1) is a nonhistone chromosomal protein primarily associated with the pericentric heterochromatin and telomeres in Drosophila. The molecular mechanism by which HP1 specifically recognizes and binds to chromatin is unknown. The purpose of this study was to test whether HP1 can bind directly to nucleosomes.
Tao Zhao +3 more
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Tissue-specific chromatin binding patterns ofC. elegansheterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression [PDF]
, 2023 Prohibitins (PHB-1 and PHB-2) form a large macromolecular structure at the mitochondrial inner membrane. Prohibitin deficiency shortens the lifespan of wild type animals, but dramatically extends the lifespan of a variety of metabolically compromised animals such as insulin/IGF-1 receptor (daf-2) mutants. This phenotype is accompanied by a differential
Patricia de la Cruz Ruiz +3 more
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Domains of Heterochromatin Protein 1 Required forDrosophila melanogasterHeterochromatin Spreading [PDF]
Genetics, 2009 AbstractCentric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1 (HP1) tethering system was
Karrie A. Hines +7 more
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The Long-Sought-After Plant Heterochromatin Protein 1 [PDF]
Molecular Plant, 2018 Rong Chen
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Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome [PDF]
Genome Research, 2010 The replication of a chromosomal region during S phase can be highly dynamic between cell types that differ in transcriptome and epigenome. Early replication timing has been positively correlated with several histone modifications that occur at active genes, while repressive histone modifications mark late replicating regions.
Michaela Schwaiger +4 more
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Recruitment of heterochromatin protein 1 to DNA repair sites [PDF]
Cytometry Part A, 2009 AbstractHeterochromatin protein 1 (HP1) was originally identified as a constitutive component of heterochromatin. However it is recognized now that it plays an important role in a number of dynamic processes in the cell nucleus, including transcriptional repression and regulation of euchromatic genes. Recent reports demonstrate that HP1 may be involved
Mirosław Zarębski +2 more
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Correction to "Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging". [PDF]
MedComm (2020)europepmc +3 more sources
Conservation of Heterochromatin Protein 1 Function [PDF]
Molecular and Cellular Biology, 2000 Heterochromatin represents a cytologically visible state of heritable gene repression. In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the donor mating-type loci, and is involved in silencing at
Wang G +6 more
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