Results 21 to 30 of about 603,291 (199)
Molecular Ecology Resources, EarlyView., 2023 Abstract A high‐quality reference genome can be a valuable resource for threatened species by providing a foundation to assess their evolutionary potential to adapt to future pressures such as environmental change. We assembled the genome of a female hihi (Notiomysits cincta), a threatened passerine bird endemic to Aotearoa New Zealand.
Sarah Bailey +7 more
wiley +1 more source
Cell Reports, 2017 RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren +5 more
doaj +1 more source
Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
doaj +1 more source
Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription. [PDF]
PLoS ONE, 2009 BACKGROUND:Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene.
Irene De Biase +3 more
doaj +1 more source
A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]
PLoS ONE 8(9): e73818, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated in the regulation of eukaryote genes and they carry numerous reversible post-translational modifications
arxiv +1 more source
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. [PDF]
PLoS Genetics, 2009 Heterochromatin Protein 1 (HP1a) is a well-known conserved protein involved in heterochromatin formation and gene silencing in different species including humans.
Lucia Piacentini +6 more
doaj +1 more source
Specificity, propagation, and memory of pericentric heterochromatin
Molecular Systems Biology, 2014 The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric ...
Katharina Müller‐Ott +11 more
doaj +1 more source
Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. [PDF]
PLoS ONE, 2009 Sister chromatid cohesion mediated by cohesin is essential for accurate chromosome segregation. Classical studies suggest that heterochromatin promotes cohesion, but whether this happens through regulation of cohesin remains to be determined ...
Angel Serrano +2 more
doaj +1 more source
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 We review here recent studies reporting the importance of both nuclear lamina components and epigenetic modifications of chromatin in nuclear mechanics. Perturbation of chromatin condensation or nuclear lamina has been linked to a plethora of biological conditions whose most studied examples are accelerated Hutchinson‐Gilford Progeria Syndrome (HGPS ...
Pietro Salvatore Carollo, Viviana Barra
wiley +1 more source
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Schematic depicting characterization of pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in neurodegenerative diseases. Abstract Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after ...
Mauro Montalbano +4 more
wiley +1 more source