TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells. [PDF]
Oncogene, 2019 Crawford NT +5 more
europepmc +2 more sources
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2 [PDF]
Genome Research, 2015 Formation of heterochromatin serves a critical role in organizing the genome and regulating gene expression. In most organisms, heterochromatin flanks centromeres and telomeres. To identify heterochromatic regions in the heavily studied model C. elegans,
Jacob M Garrigues +3 more
semanticscholar +5 more sources
Multi-scale computational studies of heterochromatin protein-1
, 2020 Liquid-liquid phase separation of intrinsically disordered proteins has recently become a foundational mechanism in molecular and cell biology. The emergent ``liquid view" is offering a fresh perspective for understanding a longstanding problem of chromatin organization and regulation in eukaryotic nuclei.
J. Mueterthies
semanticscholar +4 more sources
Conservation of Heterochromatin Protein 1 Function [PDF]
Molecular and Cellular Biology, 2000 Heterochromatin represents a cytologically visible state of heritable gene repression. In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the donor mating-type loci, and is involved in silencing at
Wang G +6 more
openaire +3 more sources
Heterochromatin protein 1 secures survival and transmission of malaria parasites. [PDF]
Cell Host & Microbe, 2014 Clonally variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable gene silencing, controls expression of numerous P.
Nicolas M. B. Brancucci +10 more
semanticscholar +5 more sources
Cells, 2023 The expression of genetic information is tightly controlled by chromatin regulatory proteins, including those in the heterochromatin gene repression family.
Sarah C. Wistner +3 more
doaj +1 more source
C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity
eLife, 2021 Caenorhabditis elegans expresses human Werner syndrome protein (WRN) orthologs as two distinct proteins: MUT-7, with a 3′−5′ exonuclease domain, and CeWRN-1, with helicase domains. How these domains cooperate remains unclear.
Tsung-Yuan Hsu +3 more
doaj +1 more source
Domains of Heterochromatin Protein 1 Required forDrosophila melanogasterHeterochromatin Spreading [PDF]
Genetics, 2009 AbstractCentric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1 (HP1) tethering system was
Karrie A, Hines +7 more
openaire +2 more sources
How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance
Cells, 2020 Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj +1 more source