Results 31 to 40 of about 612,093 (259)
The Heterochromatin Protein 1 Prevents Telomere Fusions in Drosophila [PDF]
Molecular Cell, 1998 HP1 (Heterochromatin protein 1) is a conserved, non-histone chromosomal protein that is best known for its preferential binding to pericentric heterochromatin and its role in position effect variegation in Drosophila. Using immunolocalization, we show that HP1 is a constant feature of the telomeres of interphase polytene and mitotic chromosomes.
Sergio Pimpinelli +4 more
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The chromatin remodelling factor dATRX is involved in heterochromatin formation.
PLoS ONE, 2008 Despite extensive study of heterochromatin, relatively little is known about the mechanisms by which such a structure forms. We show that the Drosophila homologue of the human alpha-thalassemia and mental retardation X-linked protein (dATRX), is ...
Andrew R Bassett +3 more
doaj +1 more source
The Heterochromatin Protein 1 family.
Genome biology, 2006 Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species.
Lori L. Wallrath +2 more
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Journal of Cell Science, 1997 ABSTRACT The actin-related proteins have been identified by virtue of their sequence similarity to actin. While their structures are thought to be closely homologous to actin, they exhibit a far greater range of functional diversity. We have localized the Drosophila actin-related protein, Arp4, to the nucleus.
Frankel, S +5 more
openaire +3 more sources
Cell Reports, 2017 RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren +5 more
doaj +1 more source
Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites [PDF]
Cell Host & Microbe, 2014 Clonally variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable gene silencing, controls expression of numerous P.
Igor Niederwieser +18 more
openaire +5 more sources
PLoS Genetics, 2005 Heterochromatin comprises a significant component of many eukaryotic genomes. In comparison to euchromatin, heterochromatin is gene poor, transposon rich, and late replicating.
Danielle Vermaak +2 more
doaj +2 more sources
Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
doaj +1 more source
Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription. [PDF]
PLoS ONE, 2009 BACKGROUND:Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene.
Irene De Biase +3 more
doaj +1 more source
Does heterochromatin protein 1 always follow code? [PDF]
Proceedings of the National Academy of Sciences, 2002 Heterochromatin protein 1 (HP1) is a conserved chromosomal protein that participates in chromatin packaging and gene silencing. A loss of HP1 leads to lethality in Drosophila and correlates with metastasis in human breast cancer cells.
Dawn A. Kirschmann +2 more
openaire +2 more sources