Results 31 to 40 of about 603,291 (199)
Genome mapping and characterization of the
BMC Genomics, 2010 Background Heterochromatin plays an important role in chromosome function and gene regulation. Despite the availability of polytene chromosomes and genome sequence, the heterochromatin of the major malaria vector Anopheles gambiae has not been mapped and
Sharakhova Maria V +6 more
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NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. [PDF]
PLoS Biology, 2012 A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin.
Kelly N DuBois +14 more
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A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells [PDF]
Biochim Biophys Acta. Gene Regulatory Mechanisms 2017
Feb;1860(2):184-195, 2017 Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular states by preventing inappropriate gene expression, and has been recently identified as the most efficient barrier to ...
arxiv +1 more source
PLoS Genetics, 2019 H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida +12 more
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SETDB1 regulates microtubule dynamics
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 SETDB1 association with microtubules inhibits microtubule polymerization and enhances their instability. SETDB1 may affect the microtubules by interacting with HDAC6 to enhance HDAC6 tubulin deacetylation activity. Abstract Objectives SETDB1 is a methyltransferase responsible for the methylation of histone H3‐lysine‐9, which is mainly related to ...
Rosari Hernandez‐Vicens +4 more
wiley +1 more source
Nature Communications, 2016 Heterochromatin protein 1 (HP1), including HP1 α, β and γ, is a family of non-histone chromatin factors thought to be involved in chromatin organization.
Kyoko Hiragami-Hamada +19 more
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Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. [PDF]
PLoS Genetics, 2010 The α-thalassemia/mental retardation X-linked protein (ATRX) is a chromatin-remodeling factor known to regulate DNA methylation at repetitive sequences of the human genome.
Claudia Baumann +2 more
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MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Frontiers in Cell and Developmental Biology, 2022 Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization.
Annika Schmidt +12 more
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HP1 recruitment in the absence of argonaute proteins in Drosophila. [PDF]
PLoS Genetics, 2010 Highly repetitive and transposable element rich regions of the genome must be stabilized by the presence of heterochromatin. A direct role for RNA interference in the establishment of heterochromatin has been demonstrated in fission yeast.
Nellie Moshkovich, Elissa P Lei
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Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays [PDF]
, 2014 Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone modification dependent chromatin interactions. In recent papers HP1 binding to nucleosomal arrays was measured in vitro and interpreted in terms of nearest-neighbor cooperative binding. This mode of chromatin interactions could lead to spreading
arxiv +1 more source