Results 31 to 40 of about 87,019 (296)
Revisiting the role of heterochromatin protein 1 in DNA repair [PDF]
Journal of Cell Biology, 2009 Heterochromatin protein 1 (HP1) is a conserved factor critical for heterochromatin organization and gene silencing. It is recruited to chromatin by its direct interaction with H3K9me (methylated lysine 9 residue of histone H3), an epigenetic mark for silenced chromatin. Now, Luijsterburg et al. (Luijsterburg, M.S., C. Dinant, H. Lans, J.
Ball, Alexander R, Yokomori, Kyoko
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ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. [PDF]
, 2009 Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1).
Bernatavichute, Yana V +9 more
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Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
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Cell Reports, 2017 RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren +5 more
doaj +1 more source
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]
, 2005 The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C. +8 more
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Linking Heterochromatin Protein 1 (HP1) to cancer progression [PDF]
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2008 All cells of a given organism contain nearly identical genetic information, yet tissues display unique gene expression profiles. This specificity is in part due to transcriptional control by epigenetic mechanisms that involve post-translational modifications of histones. These modifications affect the folding of the chromatin fiber and serve as binding
George K, Dialynas +2 more
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Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
doaj +1 more source
Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription. [PDF]
PLoS ONE, 2009 BACKGROUND:Over 15 inherited diseases are caused by expansion of triplet-repeats. Friedreich ataxia (FRDA) patients are homozygous for an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene.
Irene De Biase +3 more
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Transcription of satellite DNAs in insects [PDF]
, 2011 Chromatin condensation is an important regulatory mechanism of gene silencing as well as gene activation for the hundreds of functional protein genes harbored in heterochromatic regions of different insect species.
D. Ugarkovic +3 more
core +1 more source
Journal of Cell Science, 1997 ABSTRACT The actin-related proteins have been identified by virtue of their sequence similarity to actin. While their structures are thought to be closely homologous to actin, they exhibit a far greater range of functional diversity. We have localized the Drosophila actin-related protein, Arp4, to the nucleus.
Frankel, S +5 more
openaire +3 more sources