Results 51 to 60 of about 87,019 (296)

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi, A Pidoux, A Selmecki, aF Straight, BD Strahl, C Ketel, C Li, C Trapnell, Ca Froyd, CJ Merrick, D Kadosh, DE Gottschling, GD Shankaranarayana, H Chibana, H Chibana, J Haran, J Huang, J Huang, J Nakayama, J Pérez-Martín, J Wendland, JC Tanny, JS Smith, Ka Morano, KR Hansen, L Vasiljeva, LH Freitas-Junior, LN Rusche, M Bryk, M Bühler, M Dubarry, M Paschini, M Van het Hoog, MA Pfaller, MD De Backer, MJ McEachern, N Saksouk, PA Dumesic, PR Lephart, PR Lephart, R Kaur, RB Wilson, RJ Bennett, S Greiss, S Henikoff, S Imai, S Kueng, S Rea, SI Iwaguchi, T Jones, T Kobayashi, T Kobayashi, T Kouzarides, VM Bruno, W Shou, WS Chu, X Bi   +56 more
core   +1 more source

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

PLoS Genetics, 2019
H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami   +12 more
doaj   +1 more source

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]

, 2013
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin, Izumiya, Yoshihiro, Jung, Jae U, Kung, Hsing-Jien, Lee, Hye-Ra, Tepper, Clifford, Toth, Zsolt   +6 more
core   +3 more sources

The Heterochromatin Protein 1 family.

Genome biology, 2006
Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species.
Lomberk, Gwen, Wallrath, Lori, Urrutia, Raul   +2 more
openaire   +2 more sources

Heterochromatin protein 1 is recruited to various types of DNA damage [PDF]

Journal of Cell Biology, 2009
Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and HP1-γ are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow
Luijsterburg, M.S., Dinant, C., Lans, H., Stap, J., Wiernasz, E.S., Lagerwerf, S., Warmerdam, D.O., Lindh, M., Brink, M.C., Dobrucki, J.W., Aten, J.A., Fousteri, M.I., Jansen, G., Dantuma, N.P., Vermeulen, W., Mullenders, L.H.F., Houtsmuller, A.B., Verschure, P.J., van Driel, R.   +18 more
openaire   +6 more sources

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin

Nature Communications, 2016
Heterochromatin protein 1 (HP1), including HP1 α, β and γ, is a family of non-histone chromatin factors thought to be involved in chromatin organization.
Kyoko Hiragami-Hamada, Szabolcs Soeroes, Miroslav Nikolov, Bryan Wilkins, Sarah Kreuz, Carol Chen, Inti A. De La Rosa-Velázquez, Hans Michael Zenn, Nils Kost, Wiebke Pohl, Aleksandar Chernev, Dirk Schwarzer, Thomas Jenuwein, Matthew Lorincz, Bastian Zimmermann, Peter Jomo Walla, Heinz Neumann, Tuncay Baubec, Henning Urlaub, Wolfgang Fischle   +19 more
doaj   +1 more source

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. [PDF]

PLoS Biology, 2012
A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin.
Kelly N DuBois, Sam Alsford, Jennifer M Holden, Johanna Buisson, Michal Swiderski, Jean-Mathieu Bart, Alexander V Ratushny, Yakun Wan, Philippe Bastin, J David Barry, Miguel Navarro, David Horn, John D Aitchison, Michael P Rout, Mark C Field   +14 more
doaj   +1 more source

Assessing the Epigenetic Status of Human Telomeres [PDF]

, 2019
The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel, Vega Palas, Miguel Ángel   +1 more
core   +1 more source

Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

iScience, 2021
Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the ...
Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Philippe Mailly, Alain Prochiantz, Rajiv L. Joshi, Julia Fuchs   +5 more
doaj   +1 more source

Multi-scale computational studies of heterochromatin protein-1

, 2020
Liquid-liquid phase separation of intrinsically disordered proteins has recently become a foundational mechanism in molecular and cell biology. The emergent ``liquid view" is offering a fresh perspective for understanding a longstanding problem of chromatin organization and regulation in eukaryotic nuclei.
Jazelli Lenae Mueterthies
openalex   +4 more sources