Results 61 to 70 of about 1,693,917 (277)

The Heterochromatin Protein 1 family.

Genome biology, 2006
Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species.
Lomberk, Gwen, Wallrath, Lori, Urrutia, Raul   +2 more
openaire   +2 more sources

HP1 recruitment in the absence of argonaute proteins in Drosophila. [PDF]

PLoS Genetics, 2010
Highly repetitive and transposable element rich regions of the genome must be stabilized by the presence of heterochromatin. A direct role for RNA interference in the establishment of heterochromatin has been demonstrated in fission yeast.
Nellie Moshkovich, Elissa P Lei
doaj   +1 more source

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]

, 2009
FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond, Bastiaens, Belmont, Choi, Cushman, David G. Norman, David Llères, Elgin, Förster, Gerlich, Gilbert, Grewal, Grunstein, Huisinga, Huynh, John James, Kanda, Keppler, Kimura, Kimura, Kruhlak, Lakowicz, Lippincott-Schwartz, Llères, Luger, Luger, Luger, Misteli, Mora-Bermúdez, Mora-Bermúdez, Perche, Phair, Platani, Rhodes, Robinett, Sam Swift, Shaner, Shaner, Shav-Tal, Strukov, Swedlow, Taddei, Telford, Treanor, Tremethick, Trinkle-Mulcahy, Turner, Tóth, Vagnarelli, van Munster, Wallrabe, Wolffe, Wouters   +52 more
core   +5 more sources

Recruitment of heterochromatin protein 1 to DNA repair sites

Cytometry Part A, 2009
AbstractHeterochromatin protein 1 (HP1) was originally identified as a constitutive component of heterochromatin. However it is recognized now that it plays an important role in a number of dynamic processes in the cell nucleus, including transcriptional repression and regulation of euchromatic genes. Recent reports demonstrate that HP1 may be involved
Zarębski, Mirosław, Wiernasz, Elżbieta, Dobrucki, Jerzy   +2 more
openaire   +3 more sources

MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation

Frontiers in Cell and Developmental Biology, 2022
Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization.
Annika Schmidt, Jana Frei, Ansgar Poetsch, Ansgar Poetsch, Ansgar Poetsch, Alexandra Chittka, Alexandra Chittka, Hui Zhang, Chris Aßmann, Anne Lehmkuhl, Uta-Maria Bauer, Ulrike A. Nuber, M. Cristina Cardoso   +12 more
doaj   +1 more source

Assessing the Epigenetic Status of Human Telomeres [PDF]

, 2019
The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel, Vega Palas, Miguel Ángel   +1 more
core   +1 more source

Heterochromatin Protein 1 Is Required for the Normal Expression of Two Heterochromatin Genes in Drosophila

Genetics, 2000
Abstract The Su(var)2-5 locus, an essential gene in Drosophila, encodes the heterochromatin-associated protein HP1. Here, we show that the Su(var)2-5 lethal period is late third instar. Maternal HP1 is still detectable in first instar larvae, but disappears by third instar, suggesting that developmentally late lethality is probably the ...
B Y, Lu, P C, Emtage, B J, Duyf, A J, Hilliker, J C, Eissenberg   +4 more
openaire   +2 more sources

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis

Cell Reports, 2019
Summary: CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the maintenance of cell identity and organ development through gene silencing. However, whether CBX4 regulates human stem cell homeostasis remains unclear. Here,
Xiaoqing Ren, Boqiang Hu, Moshi Song, Zhichao Ding, Yujiao Dang, Zunpeng Liu, Weiqi Zhang, Qianzhao Ji, Ruotong Ren, Jianjian Ding, Piu Chan, Changtao Jiang, Keqiong Ye, Jing Qu, Fuchou Tang, Guang-Hui Liu   +15 more
doaj   +1 more source

Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. [PDF]

PLoS Genetics, 2010
The α-thalassemia/mental retardation X-linked protein (ATRX) is a chromatin-remodeling factor known to regulate DNA methylation at repetitive sequences of the human genome.
Claudia Baumann, Maria M Viveiros, Rabindranath De La Fuente   +2 more
doaj   +1 more source

Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays [PDF]

Journal of Physics: Condensed Matter, 2014
Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone-modification-dependent chromatin interactions.
V. B. Teif, Nick Kepper, Klaus Yserentant, Gero Wedemann, K. Rippe   +4 more
semanticscholar   +1 more source