Results 61 to 70 of about 612,093 (259)

Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences [PDF]

PNAS 103, 11527- 11532 (2006); Aug 1, 2006 no 31, 2006
Major advances in large-scale yeast two hybrid (Y2H) screening have provided a global view of binary protein-protein interactions across species as dissimilar as human, yeast, and bacteria. Remarkably, these analyses have revealed that all species studied have a degree distribution of protein-protein binding that is approximately scale-free (varies as ...
arxiv   +1 more source

Heterochromatin protein 1 regulates longevity and the mitochondrial unfolded protein response

, 2021
Prohibitins (PHB-1 and PHB-2) form a large macromolecular structure at the mitochondrial inner membrane. PHB deficiency shortens the lifespan of wild type animals, but dramatically extends that of metabolically compromised animals, such as insulin/IGF-1 receptor (daf-2) mutants.
Cruz, Patricia de la, Askjaer, Peter, Artal-Sanz, Marta   +2 more
openaire   +4 more sources

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly [PDF]

Proceedings of the National Academy of Sciences, 2012
In fission yeast, the RNAi pathway is required for centromeric heterochromatin assembly. siRNAs derived from centromeric transcripts are incorporated into the RNA-induced transcriptional silencing (RITS) complex and direct it to nascent homologous transcripts.
Jun-ichi Nakayama, Yota Murakami, Takeshi Urano, Aki Hayashi, Mayumi Ishida, Rika Kawaguchi   +5 more
openaire   +3 more sources

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions

Epigenetics, 2017
The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero   +9 more
doaj   +1 more source

Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

eLife, 2019
Heterochromatin Protein 1 (HP1) is a conserved chromosomal protein in eukaryotic cells that has a major role in directing heterochromatin formation, a process that requires co-transcriptional gene silencing mediated by small RNAs and their associated ...
Fu Yang, Zhenghui Quan, Huanwei Huang, Minghui He, Xicheng Liu, Tao Cai, Rongwen Xi   +6 more
doaj   +1 more source

Modular decomposition of protein structure using community detection [PDF]

Journal of Complex Networks (2018), cny014, 2018
As the number of solved protein structures increases, the opportunities for meta-analysis of this dataset increase too. Protein structures are known to be formed of domains; structural and functional subunits that are often repeated across sets of proteins.
arxiv   +1 more source

Components of a Pathway Maintaining Histone Modification and Heterochromatin Protein 1 Binding at the Pericentric Heterochromatin in Mammalian Cells [PDF]

Journal of Biological Chemistry, 2004
Heterochromatin is a higher order chromatin structure that is important for transcriptional silencing, chromosome segregation, and genome stability. The establishment and maintenance of heterochromatin is regulated not only by genetic elements but also by epigenetic elements that include histone tail modification (e.g.
Huawei Xin, Ho-Guen Yoon, Jun Qin, Prim B. Singh, Jiemin Wong   +4 more
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

iScience, 2021
Summary: Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2 factors studied to date act
Eilidh Carrington, Roel Henrikus Martinus Cooijmans, Dominique Keller, Christa Geeke Toenhake, Richárd Bártfai, Till Steffen Voss   +5 more
doaj  

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source