The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
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Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. [PDF]
PLoS Genetics, 2010 The α-thalassemia/mental retardation X-linked protein (ATRX) is a chromatin-remodeling factor known to regulate DNA methylation at repetitive sequences of the human genome.
Claudia Baumann +2 more
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MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
Frontiers in Cell and Developmental Biology, 2022 Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization.
Annika Schmidt +12 more
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Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
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Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis
Cell Reports, 2019 Summary: CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the maintenance of cell identity and organ development through gene silencing. However, whether CBX4 regulates human stem cell homeostasis remains unclear. Here,
Xiaoqing Ren +15 more
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HP1 recruitment in the absence of argonaute proteins in Drosophila. [PDF]
PLoS Genetics, 2010 Highly repetitive and transposable element rich regions of the genome must be stabilized by the presence of heterochromatin. A direct role for RNA interference in the establishment of heterochromatin has been demonstrated in fission yeast.
Nellie Moshkovich, Elissa P Lei
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TFIIIC Localizes Budding Yeast ETC Sites to the Nuclear Periphery [PDF]
, 2012 Peer reviewedPublisher ...
Botsios, Sotirios +3 more
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Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly [PDF]
Proceedings of the National Academy of Sciences, 2012 In fission yeast, the RNAi pathway is required for centromeric heterochromatin assembly. siRNAs derived from centromeric transcripts are incorporated into the RNA-induced transcriptional silencing (RITS) complex and direct it to nascent homologous transcripts.
Aki, Hayashi +5 more
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The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]
, 2016 open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M. +7 more
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High resolution physical mapping of single gene fragments on pachytene chromosome 4 and 7 of Rosa [PDF]
, 2015 Background: Rosaceae is a family containing many economically important fruit and ornamental species. Although fluorescence in situ hybridization (FISH)-based physical mapping of plant genomes is a valuable tool for map-based cloning, comparative ...
Khrustaleva, Ludmila I +2 more
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