Results 71 to 80 of about 76,899 (274)

Heterochromatin protein 1 regulates longevity and the mitochondrial unfolded protein response

, 2021
Prohibitins (PHB-1 and PHB-2) form a large macromolecular structure at the mitochondrial inner membrane. PHB deficiency shortens the lifespan of wild type animals, but dramatically extends that of metabolically compromised animals, such as insulin/IGF-1 receptor (daf-2) mutants.
Cruz, Patricia de la, Askjaer, Peter, Artal-Sanz, Marta   +2 more
openaire   +4 more sources

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly [PDF]

Proceedings of the National Academy of Sciences, 2012
In fission yeast, the RNAi pathway is required for centromeric heterochromatin assembly. siRNAs derived from centromeric transcripts are incorporated into the RNA-induced transcriptional silencing (RITS) complex and direct it to nascent homologous transcripts.
Jun-ichi Nakayama, Yota Murakami, Takeshi Urano, Aki Hayashi, Mayumi Ishida, Rika Kawaguchi   +5 more
openaire   +3 more sources

LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer [PDF]

, 2015
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer. It is local-ized in different cellular compartments, but its nuclear function has not been investigated so
Aceto, Andrulis, Bartke, Beer, Bhattacharyya, Chubb, Finlan, Giamas, Grewal, Guelen, Heger, Hendrickx, Hung, Hurtado, Iyengar, Kathiriya, Kind, Kotera, Kumaran, Lee, Li, Li, Lin, Lo, Meuleman, Mohammed, Nielsen, Peng, Peric-Hupkes, Pickersgill, Poleshko, Pérez-Tenorio, Rajhans, Reddy, Roux, Roy, Ryan, Sadaie, Silva, Solovei, Stebbing, Stebbing, Towbin, van der Lee, Vizcaíno, Vogel, Wang, Weis, White, Xu, Yokoe, Zeng, Ziv   +52 more
core   +4 more sources

Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

eLife, 2019
Heterochromatin Protein 1 (HP1) is a conserved chromosomal protein in eukaryotic cells that has a major role in directing heterochromatin formation, a process that requires co-transcriptional gene silencing mediated by small RNAs and their associated ...
Fu Yang, Zhenghui Quan, Huanwei Huang, Minghui He, Xicheng Liu, Tao Cai, Rongwen Xi   +6 more
doaj   +1 more source

Components of a Pathway Maintaining Histone Modification and Heterochromatin Protein 1 Binding at the Pericentric Heterochromatin in Mammalian Cells [PDF]

Journal of Biological Chemistry, 2004
Heterochromatin is a higher order chromatin structure that is important for transcriptional silencing, chromosome segregation, and genome stability. The establishment and maintenance of heterochromatin is regulated not only by genetic elements but also by epigenetic elements that include histone tail modification (e.g.
Huawei Xin, Ho-Guen Yoon, Jun Qin, Prim B. Singh, Jiemin Wong   +4 more
openaire   +3 more sources

The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

iScience, 2021
Summary: Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2 factors studied to date act
Eilidh Carrington, Roel Henrikus Martinus Cooijmans, Dominique Keller, Christa Geeke Toenhake, Richárd Bártfai, Till Steffen Voss   +5 more
doaj  

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. [PDF]

, 2018
Enhanced telomere maintenance is evident in malignant cancers. While telomeres are thought to be inherently heterochromatic, detailed mechanisms of how epigenetic modifications impact telomere protection and structures are largely unknown in human ...
Blackburn, Elizabeth H, Chow, Tracy T, Guan, Juan, Huang, Bo, Shi, Xiaoyu, Stadler, Guido, Wei, Jen-Hsuan   +6 more
core   +3 more sources

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions

Epigenetics, 2017
The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero   +9 more
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source