Results 71 to 80 of about 603,291 (199)
Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells
Frontiers in Pharmacology, 2018 Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic ...
Satoshi Imanishi +5 more
doaj +1 more source
Human cell recovery after microwave irradiation [PDF]
arXiv, 2009 Cells of human buccal epithelium of 6 male donors were exposed to microwave radiation (frequency f=36,64 GHz, power density E = 10, 100, and 400 mcW/cm^2). Exposure time in all experiments was 10 seconds. Heterochromatin was stained by 2% orcein in 45 % acetic acid. The stainability of cells with trypan blue (0,5 %) and indigocarmine (5 mM) after 5 min
arxiv
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, EarlyView.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
iScience, 2021 Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the ...
Camille Ravel-Godreuil +5 more
doaj
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, EarlyView.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing
Epigenetics & Chromatin, 2011 Background Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of ...
Maksakova Irina A +7 more
doaj +1 more source
Changes in chromatin state in donors subjected to physical stress [PDF]
arXiv, 2009 The purpose of the present study is to evaluate changes in chromatin of human buccal epithelium under the influence of stressing factor - dosed physical activity. Investigations were performed in a group of students (13 men) of age 19-23. Cells were stained on a slide by a 2% orcein solution in 45% acetic acid during 1 h.
arxiv
Properties of Chromatin in Human Cells as Characteristics of the State of Human Organism: A Review [PDF]
Adv Complement Alt Med. 1(1). ACAM.000505. 2018.
http://crimsonpublishers.com/acam/volume1-issue1-acam.php, 2018 The state of chromatin in individual cells is directly related to the state of the whole organism and may be used for assessment of the state of the whole organism. Many hereditary diseases are connected with chromatin rearrangements. Chromatin distribution in cell nucleus is an important characteristic which may be applied for determination of disease
arxiv
RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection
Molecular Ecology Resources, EarlyView.ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone +3 more
wiley +1 more source
Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis
Cell Reports, 2019 Summary: CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the maintenance of cell identity and organ development through gene silencing. However, whether CBX4 regulates human stem cell homeostasis remains unclear. Here,
Xiaoqing Ren +15 more
doaj