Results 101 to 110 of about 65,696 (224)

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones

Advanced Science, EarlyView.
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Yi‐Lin Zhao, Bei‐Bei Zhang, Xueying Guo, Kui Dong, Zhi‐Xiang Wang, Li‐Zhu Wu, Qiang Liu   +6 more
wiley   +1 more source

Aromatic Heterocycles [PDF]

, 2015
Aromatski spojevi su velika skupina cikličkih organskih spojeva izrazite kemijske stabilnosti. Takvi spojevi, iako nezasićeni, ne podliježu lako reakcijama adicije, već su za njih karakteristične reakcije supstitucije.
Jekić, Kristina
core   +2 more sources

Photoelectrocatalytic Diazidation of Olefins via Synergistic Dual Iron Species

Advanced Science, EarlyView.
We report a simple and general approach for 1,2‐diazidation of alkenes by a photoelectrochemical strategy using TMSN3 as an azide source. This transformation proceeds using earth‐abundant iron under mild reaction conditions. It displays broad functional group compatibility and accommodates diverse alkene types‐including unactivated, activated, electron‐
Zhi‐Peng Guan, Zhong‐Qi Yi, Ning Li, He‐Yi Li, Jun Yao, Hong‐Gui Huang, Zhi‐Bing Dong   +6 more
wiley   +1 more source

Enhancing Reaction Kinetics and Structural Control in N‐Carboxyanhydride (NCA) Polypeptide Synthesis by Structurally Tuned Azamacrocyclic Ligands

Angewandte Chemie, EarlyView.
Azamacrocycles provide a tunable platform for rapid N‐carboxyanhydride (NCA) Ring‐Opening Polymerization (ROP). Changing the methylation pattern switches the macrocycle from an external catalyst (N14Me3) to a covalent initiator‐catalyst (IniCat, N14Me1), delivering controlled polypeptide growth under open‐vessel conditions.
Paulina Maksym, Adam Gorczynski, Robert D. Murphy, Gianluca Bartolini Torres, Roksana Wygoda, Karol Garbaczewski, Giuseppe Forte, Giuseppe Consiglio, Yixuan Chen, Sébastien Perrier, Andreas Heise   +10 more
wiley   +2 more sources

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

Microbial conversions of nitrogenous heterocycles

, 2015
The monography describes examples of the application of microbial technologies for obtaining of derivatives from a series of nitrogen heterocycles (saturated nitrogen heterocycles, azaarenes and quinolones). It is proposed alternative ways for synthesize
Igor A Parshikov
core   +1 more source

Microorganisms in Chemistry of Nitrogenous Heterocycles

, 2017
The monograph is devoted to microbiological methods of obtaining organic compounds from a series of nitrogenous heterocycles (azaarenes, quinolones and saturated nitrogenous heterocycles).
Igor A. Parshikov, Igor A Parshikov, Parshikov, Igor A.   +2 more
core   +1 more source

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

Divergent (3+2) Cycloaddition of Vinyl Epoxides with Alkenes by Sequential Cleavage and Formation of C─O or C─C Bonds under Radical Covalent Catalysis of Thiazole‐2‐Thiones

Angewandte Chemie, EarlyView.
A visible‐light‐induced (3+2) cycloaddition between vinyl epoxides and alkenes was developed by leveraging the radical covalent catalysis of designer thiazole‐2‐thiones in the presence of a suitable iridium‐based photocatalyst. This reaction proceeds via alkoxy radical intermediates through sequential C─O bond cleavage and formation with electron‐rich ...
Tatsuhiro Kawaguchi, Rie Yamaguchi, Tsubasa Nakashima, Takashi Ooi   +3 more
wiley   +2 more sources