Results 21 to 30 of about 58,285 (293)

A Brief Review on the Synthesis of the N-CF₃ Motif in Heterocycles

Molecules, 2023
The trifluoromethyl group is widely recognized for its significant role in the fields of medicinal chemistry and material science due to its unique electronic and steric properties that can alter various physiochemical properties of the parent molecule ...
Zizhen Lei, Wenxu Chang, Hong Guo, Jiyao Feng, Zhenhua Zhang   +4 more
doaj   +1 more source

N‐Heterocyclic Carbenes [PDF]

European Journal of Inorganic Chemistry, 2009
The N-heterocyclic carbenes (NHC) now hold a preferred-ligand status in organic and organometallic chemistry. Their role in catalysis continues to grow. When the editorial staff at the Beilstein Journal of Organic Chemistry contacted me to act as a guest editor for the thematic series “N-Heterocyclic carbenes”, I was more than happy to accept what ...
openaire   +3 more sources

In silico screening of drug-like molecules for the treatment of cardiovascular diseases on the basis of five-membered privileged heterocycles

Фармацевтичний журнал, 2019
Among various heterocyclic systems, the derivatives of five-membered heterocycles are of special interest. Most of the above mentioned heterocycles are treatred as so-called privileged structures in modern medicinal chemistry.
І. V. Drapak
doaj   +1 more source

N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles

Beilstein Journal of Organic Chemistry, 2021
The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from tert-butanesulfinamide ...
Joseane A. Mendes, Paulo R. R. Costa, Miguel Yus, Francisco Foubelo, Camilla D. Buarque   +4 more
doaj   +1 more source

4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

CHIMIA, 2023
4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant.
Juan J. Rojas, James A. Bull
doaj   +1 more source

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

Nature Communications, 2020
Heterocycles containing difluoromethyl groups are molecules with potential application in pharmaceutical, agricultural and materials science. Here, the authors show an organophotocatalytic difluoromethylation of heterocycles using O2 as green oxidant and
Wei Zhang, Xin-Xin Xiang, Junyi Chen, Chen Yang, Yu-Liang Pan, Jin-Pei Cheng, Qingbin Meng, Xin Li   +7 more
doaj   +1 more source

Adventures with Heterocycles.

Chemical and Pharmaceutical Bulletin, 2000
Elucidation of mechanisms and discovery of novel reactions are interconnected, as four research chapters from the Munich laboratory demonstrate. 1) In a new opening of the furan ring, 2-methoxyfuran and tetra-acceptor-substituted ethylenes furnish methyl acrylates, which are cis-3-substituted by a cyclopropyl ring that bears the four acceptor groups ...
openaire   +3 more sources

Tailoring Li‐ion Storage and Transport in Two‐Dimensional Conjugated Metal‐Organic Frameworks via Precise Nitrogen Incorporation

Advanced Functional Materials, EarlyView.
Two nitrogen‐doped 2D conjugated metal‐organic frameworks (2D c‐MOFs, namely Cu‐Nx‐OHBA, x = 2 or 4) are synthesized, featuring precise nitrogen incorporation via rational ligand design. The Cu‐Nx‐OHBA 2D c‐MOFs are largely tailorable by varying skeletal nitrogen density, with respect to electrical conductivity, Li‐storage capacitance, and Li‐transport
Xiangyu Li, Shaoze Shi, Fucai Cui, Rashid Iqbal, Pengyu Wang, Tianrui Wu, Jingcheng Hao, Renhao Dong   +7 more
wiley   +1 more source

Recent Advancements in Photocatalytic Synthesis of Five Membered Nitrogen Heterocycles and Their Derivatives

Molecules
Photocatalytic synthesis of heterocycles has emerged as a versatile strategy in organic synthesis. Among various heterocycles, five membered heterocycles such as pyrroles, indoles and their derivatives have great significance based on their ...
Zeeshan Haider, Ravi Archana, Heongkyu Ju   +2 more
doaj   +1 more source

Nitrogen heterocycles form peptide nucleic acid precursors in complex prebiotic mixtures

Scientific Reports, 2019
The ability to store information is believed to have been crucial for the origin and evolution of life; however, little is known about the genetic polymers relevant to abiogenesis.
Laura E. Rodriguez, Christopher H. House, Karen E. Smith, Melissa R. Roberts, Michael P. Callahan   +4 more
doaj   +1 more source