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Lancet, The, 1999 Background Heterocyclic amines formed in cooked meat and fish are carcinogenic in animal models and form DNA adducts in human beings. We undertook a study to assess whether these substances are related to the risks of cancer in the large bowel and ...
Gunnar Steineck +2 more
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Overview of Carcinogenic Heterocyclic Amines
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997exaly +3 more sources
Health risks of heterocyclic amines
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997Common cooking procedures such as broiling, frying, barbecuing (flame-grilling), heat processing and pyrolysis of protein-rich foods induce the formation of potent mutagenic and carcinogenic heterocyclic amines. These same compounds produce tumors at multiple organ sites in both mice and rats.
J S, Felton +5 more
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Heterocyclic amines: Chemistry and health
Molecular Nutrition & Food Research, 2006AbstractHeterocyclic amines (HAs) occur at the ppb range in foods. Most of them demonstrate potent mutagenicity in bacteria mutagenicity test, and some of them have been classified by the International Agency for Research on Cancer as probable/possible human carcinogens.
Wang, M, Cheng, KW, Chen, F
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Analysis of heterocyclic aromatic amines
Analytical and Bioanalytical Chemistry, 2007Heterocyclic aromatic amines are formed in protein and amino acid-rich foods at temperatures above 150 degrees C. Of more than twenty heterocyclic aromatic amines identified ten have been shown to have carcinogenic potential. As nutritional hazards, their reliable determination in prepared food, their uptake and elimination in living organisms ...
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HETEROCYCLES, 1994
Heterocyclic ketene aminals are presented in view of their synthesis, reactions and applications in the preparation of fused ...
Zhi-Tang Huang +2 more
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Heterocyclic ketene aminals are presented in view of their synthesis, reactions and applications in the preparation of fused ...
Zhi-Tang Huang +2 more
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α-Amination of Nitrogen Heterocycles: Ring-Fused Aminals
Journal of the American Chemical Society, 2007Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process is applied to two-step syntheses of the quinazolinone alkaloids deoxyvasicinone and rutaecarpine.
Chen, Zhang +3 more
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Assessing human risk to heterocyclic amines
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997Heterocyclic amines such as MeIQx and PhIP are potent genotoxic chemicals which are formed at part per billion levels when meat is cooked. Using assays based on gas chromatography/mass spectrometry with stable isotope labelled analogues as internal standards we have demonstrated MeIQx and PhIP, are efficiently absorbed into the systemic circulation ...
N J, Gooderham +7 more
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Sulfotransferase catalyzing sulfation of heterocyclic amines
Cancer Letters, 1999Cytosolic sulfation of arylamines to form sulfamates is found to be mediated by sulfotransferases of three gene families (SULT1 to 3). Among them, a SULT3 form (ST3A1) showed a high selectivity for N-sulfation of N-substituted aryl and alicyclic compounds.
Y, Yamazoe +5 more
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Carcinogenicities of heterocyclic amines in cooked food
Mutation Research/Genetic Toxicology, 1991Mutagenic heterocyclic amines in cooked foods were carcinogenic to mice, rats and/or monkeys, when they were given orally continuously. The most common target organ was the liver, but in CDF1 mice lung tumors, forestomach tumors, lymphomas/leukemias, and blood vessel tumors in the brown adipose tissues were also induced.
H, Ohgaki, S, Takayama, T, Sugimura
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