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Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines.
Princess Takamatsu symposia, 19972-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4,5-b]pyridine (4'-OH-PhIP) was mutagenic, inducing 180 revertants of Salmonella typhimurium TA98 per 100 micrograms with S9 mix and was formed by heating a mixture of creatine, tyrosine and glucose. It was detected in broiled beef at a level of 21.0 ng per g of broiled beef, which is comparable to the level ...
K, Wakabayashi +9 more
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Genetic changes induced by heterocyclic amines
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997Clarification of the mutational fingerprints of HCAs offers a promising approach in the investigation of the role of heterocyclic amines (HCAs) in human carcinogenesis. We analyzed mutations in the tumor related genes of tumors induced by HCAs, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), and 2-amino-
M, Nagao +4 more
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Immunological Methods for Dosimetry of Heterocyclic Amines
1996Carcinogenic heterocyclic amines are formed by common household cooking procedures, and it is therefore of interest to evaluate exposures in the general population. High-affinity monoclonal antibodies to 2-amino-l-methyl-6-phenyl- imidazo[4,5-b]pyridine (PhIP1) were produced and a sensitive fluorescence-based ELISA assay developed with a 50% inhibition
L O, Dragsted +4 more
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An epidemiologic approach to studying heterocyclic amines
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002Diets containing substantial amounts of red meat may increase the risk of colorectal, pancreatic, breast, prostate, and renal cancer. The association with red meat intake may be due to a combination of factors, such as content of fat, protein, and iron, and/or meat preparation (e.g. cooking or preserving methods).
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The Biological Oxidation of Aromatic Heterocyclic Amines
Xenobiotica, 1971Abstract1. Heterocyclic aromatic amines occur in many drugs and foreign compounds, as well as products of intermediary metabolism.2. Heterocyclic aromatic amine oxides occur naturally in plants, fungi and other micro-organisms but are rare in mammalian systems.3. Very few xenobiotics have been reported to form heterocyclic aromatic amine oxides and the
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Aromatic Amines, Nitroarenes, and Heterocyclic Aromatic Amines
1999Publisher Summary This chapter describes the aromatic amines, nitroarenes, and heterocyclic aromatic amines. Aromatic amines are important intermediates for the production of polymers, pesticides, rubber chemicals, dyes, pigments, and pharmaceuticals.
G. Sabbioni, E. Richter
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2005
We identified three new mutagenic heterocyclic amines (HCAs), 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4, 5- b ]pyridine (4'-OH-PhIP) in broiled beef, and 2-amino-4-hydroxymethyl-3, 8-dimethylimidazo[4, 5- f ]quinoxaline (4-CH 2 OH-8-McIQx) and 2-amino-1, 7,9-trimethylimidazo[4, 5- g ]quinoxaline (7, 9-DiMelgQx) in beef extract.
K. Wakabayashi +9 more
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We identified three new mutagenic heterocyclic amines (HCAs), 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo[4, 5- b ]pyridine (4'-OH-PhIP) in broiled beef, and 2-amino-4-hydroxymethyl-3, 8-dimethylimidazo[4, 5- f ]quinoxaline (4-CH 2 OH-8-McIQx) and 2-amino-1, 7,9-trimethylimidazo[4, 5- g ]quinoxaline (7, 9-DiMelgQx) in beef extract.
K. Wakabayashi +9 more
openaire +1 more source