Results 121 to 130 of about 46,339 (188)

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4-Thiadiazole-Based Heterocycles as Potential Anticancer and Antioxidant Agents. [PDF]

Chem Biol Drug Des
El-Metwaly NM, Alrefaei AF, Alshareef HF, Almehmadi SJ, Alotaibi FA, Alshammari NM, Ebaid MS, Katouah HA.   +7 more
europepmc   +1 more source

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds. [PDF]

J Comput Chem
da Silva LA, Rosa NMP, Cantini DFV, Anastácio AC.   +3 more
europepmc   +1 more source

Recent advances in synthesis and medicinal chemistry of pyrrolodiazepines. [PDF]

Front Chem
Zhou M, Wang S.
europepmc   +1 more source

Unlocking the Potential of Isatin Scaffolds in Acetylcholinesterase Inhibition. [PDF]

Arch Pharm (Weinheim)
Tharwat T, El-Nassan HB, Adly ME, Kamel MM.   +3 more
europepmc   +1 more source

Design, synthesis, <i>in silico</i> studies, and biological evaluation of tosyl-substituted thiazoles, thiazolidin-4-ones, and chromenes as potential anticancer agents. [PDF]

RSC Adv
Said GE, Samy S, Abdel-Galil E, Gaffer HE, Abdel-Latif E.   +4 more
europepmc   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Silver-catalyzed anionic [3 + 2] cycloaddition of benzyl isocyanides with polyfluoroalkylchromones and pyrones: direct synthesis of 2-arylpyrroles. [PDF]

Beilstein J Org Chem
Kochnev IA, Barkov AY.
europepmc   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure-Activity Relationship Frameworks, Landscapes, and Optimization Approaches. [PDF]

Chem Biodivers
Dhangar MS, Palkar MB.
europepmc   +1 more source

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Structure-Activity Relationship for Inflammasome Inhibition by Thiomuscimol. [PDF]

Int J Mol Sci
Anderson MJ, Loomis WP, den Hartigh AB, Frølund B, Fink SL.   +4 more
europepmc   +1 more source