Results 131 to 140 of about 46,339 (188)

Antitumor and proliferative modulation by N- and O-heterocycles: a comprehensive review of cell growth regulation. [PDF]

Front Chem
Chinibayeva N, Unerbaeva Z, Shepilov D, Berganayeva G, Liu J, Pu X, Nurmahanova A, Zhaksylykova G, Sydykbayeva S, Dyusebaeva M.   +9 more
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Synthesis, anti-proliferative evaluation, DFT, <i>in silico</i> ADME and molecular modeling studies of novel imidazolones as potential EGFR inhibitors. [PDF]

RSC Adv
Hekal MH, Abdel-Megid M, Salem ME, Alrashdi S, Alzahrani AYA, Abu El-Azm FSM.   +5 more
europepmc   +1 more source

Quinazolinone as Bioactive Pharmacophore: Synthesis and Biological Activities. [PDF]

Chem Biodivers
Aggarwal M, Sharma S, Utreja D.
europepmc   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

The Role of Pyrrolidine in Antibacterial Drug Discovery: Clinically Approved Antibiotics, Novel Derivatives, and Future Perspectives. [PDF]

Int J Mol Sci
Rusu A, Stroia IM, Hancu G, Tanase C, Uncu L.   +4 more
europepmc   +1 more source

The Epoxybenzooxocine Core of Integrastatins and Analogs: A Comprehensive Review of Structure, Synthetic Approaches, and Biological Applications. [PDF]

ACS Omega
Rakhimzhanova AS, Pustolaikina IA, Kurmanova AF, Muzaparov RA, Kapishnikova DD, Stalinskaya AL, Kulakov IV.   +6 more
europepmc   +1 more source

Synthesis and Cytotoxic Activity of 1,3-Selenazole-2-Amine Derivatives With Computational ADMET Profiling. [PDF]

ChemistryOpen
Dilek G, Akkoc S.
europepmc   +1 more source

Alkaloids as Emerging Neuroprotective Agents for Neurodegenerative Disorders: Insights into Tryptanthrin and Its Derivatives. [PDF]

Int J Mol Sci
Khan A, Khan H, Park IH, Aldahmash BA, Khan MS, Yang G, Kang KS.   +6 more
europepmc   +1 more source

Interfacial Mn‐Carbon Nitride Synergy Enables Selective Photocatalytic C─H Chlorination via Single‐Atom Catalysis

Angewandte Chemie International Edition, EarlyView.
A manganese single‐atom photocatalyst on functionalised carbon nitride enables selective visible‐light‐driven C(sp2)─H chlorination. DFT‐supported mechanistic studies indicate that photoinduced charge separation activates NCS, while isolated Mn sites stabilize Mn─Cl intermediates at the catalyst interface.
Jaro Vanderghinste, Prakash Kumar Sahoo, Xinbang Wu, Thanh Huyen Vuong, Anna Rokicińska, Susanna Monti, Giovanni Barcaro, Alina Skorynina, Aleksander Jaworski, Vivien Michaelis, Jabor Rabeah, Julia Bornhorst, Laura Simonelli, Piotr Kuśtrowski, Adam Slabon, Paul J. Dyson, Shoubhik Das   +16 more
wiley   +1 more source