Results 51 to 60 of about 3,269,112 (357)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Synthesis and investigations of heterocyclic compounds as corrosion inhibitors for mild steel in hydrochloric acid

International Journal of Industrial Chemistry, 2019
The corrosion inhibition of mild steel in 0.5 M hydrochloric acid by six synthesized heterocyclic compounds was studied using weight loss measurements. The inhibition efficiency exceeded 95%.
Salima K. Ahmed, W. Ali, A. Khadom
semanticscholar   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Using Quinolin-4-Ones as Convenient Common Precursors for a Metal-Free Total Synthesis of Both Dubamine and Graveoline Alkaloids and Diverse Structural Analogues

Molecules
The Rutaceae family is one of the most studied plant families due to the large number of alkaloids isolated from them with outstanding biological properties, among them the quinoline-based alkaloids Graveoline 1 and Dubamine 2.
Rodrigo Abonia, Lorena Cabrera, Diana Arteaga, Daniel Insuasty, Jairo Quiroga, Paola Cuervo, Henry Insuasty   +6 more
doaj   +1 more source

The mathematical description of the electrosynthesis of composites of oxy-hydroxycompounds cobalt with polypyrrole overooxidazed [PDF]

, 2016
The electrosynthesis of the composite with of the overoxidized polypyrrole with cobalt oxy-hydroxide in strongly acidic media has been described mathematically, using linear stability theory and bifurcation analysis. The steadystates stability conditions
Maia, J., Ojani, R., Oliveira de, C. S., Soares, B. Gunter, Tkach, V., Yagodinez, P. I.   +5 more
core   +2 more sources

Designing Thermally Compatible Template‐Coating Pairs Toward Dimensionally Stable 3D Porous Carbons with Tunable Density

Advanced Functional Materials, EarlyView.
3D porous carbons with tunable density are crucial for energy storage, separations, and load‐bearing applications; however, their fabrication is often constrained by shrinkage during pyrolysis. This study optimizes and demonstrates the versatility of a template–coating pair strategy, producing materials that largely retain their shape and hierarchical ...
Adarsh Suresh, Manuela Campos, Kendrick Xie, Elektra Makris, Jonah Lovejoy, Maya El Shamsy, Chong Liu, Stuart J Rowan   +7 more
wiley   +1 more source

Novel "green" catalysts for controlled ring-opening polymerization of lactide [PDF]

, 2010
Syntéza polylaktidu (PLA) polymerací za otevření kruhu cyklického monomeru (ROP) může být uskutečněna různými způsoby. Literatura uvádí více než 100 katalytických systémů, jejichž pomocí lze polylaktid a jiné biodegradabilní alifatické polyestery získat.
Surman, František
core  

An electron-deficient triosmium cluster containing the thianthrene ligand: Synthesis, structure and reactivity of [Os₃(CO)₉(μ3-η2-C₁₂H₇S₂)(μ-H)] [PDF]

, 2008
Reaction of [Os₃(CO)₁₀(CH₃CN)₂] with thianthrene at 80 °C leads to the nonacarbonyl dihydride compound [Os₃(CO)₉(μ-3,4-η²-C₁₂H₆S₂)(μ-H)₂] (1) and the 46-electron monohydride compound [Os₃(CO)₉(μ₃-η²-C₁₂H₇S₂)(μ-H)] (2).
Hassan, Mohammad R., Kabir, Shariff E., Karim, Md. Manzurul, Nicholson, Brian K., Raha, Arun K., Rosenberg, Edward, Salassa, Luca, Sharmin, Ayesha   +7 more
core   +1 more source

Stabilizing Cationic Palladium Single‐Atom Sites on Heteroatom‐Doped Carbon for Selective Hydrogen Peroxide Electrosynthesis

Advanced Functional Materials, EarlyView.
In this research, it is demonstrated that dual nitrogen and sulfur doping in hollow carbon spheres creates a tunable coordination environment that stabilizes cationic Pd single atoms as robust organometallic complexes, enabling high selectivity and stability for electrochemical hydrogen peroxide production under harsh acidic and peroxide‐rich ...
Guilherme V. Fortunato, Alexander Gunnarson, Hannaneh Hosseini, Xiangyu You, Pallabi Bhuyan, Ji Sik Choi, Hyo Sang Jeon, Xingshen Zhao, Julio C. Lourenço, Sumin Lim, Huize Wang, Ana Guilherme Buzanich, Martin Radtke, Paul Paciok, Marcos R.V. Lanza, Ferdi Schüth, Marc Ledendecker   +16 more
wiley   +1 more source

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

Beilstein Journal of Organic Chemistry, 2022
A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments.
Anna V. Korotina, Svetlana G. Tolshchina, Rashida I. Ishmetova, Natalya P. Evstigneeva, Natalya A. Gerasimova, Natalya V. Zilberberg, Nikolay V. Kungurov, Gennady L. Rusinov, Oleg N. Chupakhin, Valery N. Charushin   +9 more
doaj   +1 more source