Results 51 to 60 of about 96,191 (265)

Diffraction and database analyses of photoactive biphenyl compounds and novel carbaborane structures [PDF]

, 1999
The research involved in this thesis is mainly concerned with crystallography and the analysis using crystallographic techniques and methods. The work in this thesis is centered mainly on two types of chemical compounds, photoactive compounds and ...
Mackinnon, Angus
core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Magnetic decorated 5-sulfosalicylic acid grafted to chitosan: A solid acid organocatalyst for green synthesis of quinazoline derivatives

Carbohydrate Polymer Technologies and Applications
In this research, a new magnetically decorated multifunctional solid acid was designed and prepared conveniently by grafting of 5-sulfosalicylic acid (SSA) onto the chitosan (CS) backbone using toluene-2,4-diisocyanate (TDI) linker for the first time ...
Reyhaneh Peyvasteh Sourkouhi, Mohammad G. Dekamin, Ehsan Valiey, Mohammad Dohendou   +3 more
doaj   +1 more source

Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

Beilstein Journal of Organic Chemistry, 2012
The chemical similarity of antibacterial cyclic peptides and peptidomimetics was studied in order to identify new promising cyclic scaffolds. A large descriptor space coupled with cluster analysis was employed to digitize known antibacterial structures ...
Workalemahu M. Berhanu, Mohamed A. Ibrahim, Girinath G. Pillai, Alexander A. Oliferenko, Levan Khelashvili, Farukh Jabeen, Bushra Mirza, Farzana Latif Ansari, Ihsan ul-Haq, Said A. El-Feky, Alan R. Katritzky   +10 more
doaj   +1 more source

Crystal structures of ethyl {2-[4-(4-isopropylphenyl)thiazol-2-yl]phenyl}carbamate and ethyl {2-[4-(3-nitrophenyl)thiazol-2-yl]phenyl}carbamate

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C21H22N2O2S (I) and C18H15N3O4S (II), are structural analogs of the alkaloid Thiosporine B. Both molecules adopt a near-planar V-shaped conformation, which is consolidated by intramolecular N—H...N and C—H...O hydrogen bonds.
Elena V. Sukhonosova, Sergey A. Sokov, Gennady I. Ostapenko, Alexander S. Bunev, Pavel V. Dorovatovskii, Yan V. Zubavichus, Victor N. Khrustalev   +6 more
doaj   +1 more source

Green synthesis of highly functionalized heterocyclic bearing pyrazole moiety for cancer-targeted chemo/radioisotope therapy

BMC Chemistry, 2023
New derivatives of heterocyclic bearing pyrazole moiety were synthesized (eight new compounds from 2 to 9) via green synthesis methods (microwave-assisted and grinding techniques).
Kurls E. Anwer, Galal H. Sayed, Basma M. Essa, Adli A. Selim   +3 more
doaj   +1 more source

Processed Meat and Colorectal Cancer: A Review of Epidemiologic and Experimental Evidence [PDF]

, 2008
Processed meat intake may be involved in the etiology of colorectal cancer, a major cause of death in affluent countries. The epidemiologic studies published to date conclude that the excess risk in the highest category of processed meat-eaters is ...
Santarelli, Raphaëlle, L., Pierre, Fabrice, Pierre, Fabrice H.F., Santarelli, Raphaëlle L., Corpet, Denis E.   +4 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Bionanocomposite MIL-100(Fe)/Cellulose as a high-performance adsorbent for the adsorption of methylene blue

Scientific Reports
World production of dyes is estimated at more than 800,000 t·yr−1. The purpose of this research falls within the scope of the choice of an effective, local, and inexpensive adsorbent to remove dyes from wastewater.
Shahla Abbasi, Zahra Nezafat, Shahrzad Javanshir, Behzad Aghabarari   +3 more
doaj   +1 more source

Polyfunctionalised pyrimidines and pyrazines from perhalogenated precursors [PDF]

, 2008
Chapter 1 introduces the modem pharmaceutical industry in terms of the drug discovery process leading into a discussion of the relevance of heterocyclic compounds with particular focus on the synthesis of multifunctional pyrimidines and pyrazines.
Parks, Emma Louise
core